Hair loss cover story

Membership Theoretical consideration of the effect of black beans | Korea's No.1 Hair Loss Community, DAEDAMO

머리숱좀쳐주시구요 · 2013-02-15T01:45:24+09:00

As most members know Pinasteride is a 5α reductase type 2 inhibitor It suppresses hair loss by reducing blood DHT concentration by 70 and scalp DHT concentration by 38 Dutasteride components are suppressed to type 1 reduction It has a stronger DHT inhibitory mechanism than finasteride 92 scalp 55 But the fact that a strong DHT inhibition rate doesnt directly link to a good effect A lot of people are aware of it Thats how complicated the mechanism of hair loss is I found something interesting at this point At the beginning of the hair loss treatment Compared to dutasteride which is not stable yet Pinasteride which is less at risk of side effects is chosen first 5 alpha reductase type 1 and 2 are not just for making DHT So far from a longterm perspective the significance of the difference between the effectiveness of Pinna Dutta and Dutta has been I cant affirm it because I havent confirmed the results of the study But Dutasteride is expected to be very effective It is true that the choice of pinasteride leaves a regret This question arose from the choice without an alternative Cant I suppress it to 5α reductase type 1 without taking Dutta The clue was in the beans According to my research paper isoflavone an ingredient in beans It is said to have the effect of inhibiting 5αreductase type 1 The concentration of isoflavone concentrate up to 25μgml It increased proportionally but at a concentration of 50㎍㎖ compared to 25㎍㎖ The inhibitory effect did not increase significantly 50 μgml of isoflavone It showed a type 1 inhibition rate of over 80 at the concentration Then the problem is the concentration of isoflavone in the blood If you can maintain a certain level of isoflavone concentration in your blood It means that type 1 can be suppressed According to the paper isoflavones with concentrations of 156㎍ml and 313㎍ml respectively Concentrate alone inhibited type 1 in cells to around 25 and 40 So I looked for more papers on isoflavones and blood levels If you take 50 mg of isoflavone a day your blood isoflavone concentration is According to research by Setchell et al 005㎍㎖02㎍㎖ was investigated According to a study by King et al 005㎍ml to 08㎍ml maximum was investigated But most of them were found to be around 01㎍㎖ Theres a big deviation but compared to the concentration of isoflavone concentrate I mentioned earlier You can see that its a ridiculously small amount In order to achieve a relatively low type 1 inhibition rate effect of 25 A blood isoflavone concentration of 156 μgml or more is required With a maximum of 08μgml expected from 50mg of isoflavone intake per day Even if calculated we can predict that it will be well below the 25 inhibition rate In fact 50mg of isoflavone per day is 2 packs of soy milk 50g of black beans 500g of tofu Its enough to meet 50mg each If you overdo it and eat all three Its 150mgday From here we need speculation It is assumed that the blood concentration according to the isoflavone intake is linear Its going to be kind of a hypothesis because you cant actually do experiments If the blood concentration is 005μgml to 02μgml when you take 50mg When you take 500mg its 050μgml to 20μgml As mentioned earlier most of the 50 mg concentration is around 01μgml When calculating with realistic figures considering what has been shown If you take 500mg of isoflavone a day its about 10㎍ml It can be predicted that it will indicate blood concentration Of course assuming theres a linear correlation lol When I think this far Im going to think about the effectiveness of black beans I felt like the question was solved The 5αreductase type 1 inhibition mechanism of isoflavone It wont be as simple as I thought If you guess roughly youve been talking about the uselessness of black beans I think I can provide a small basis All of the assumptions Ive presented are from the isoflavone effect Its an arbitrary interpretation from the most advantageous aspect 5α reductase regardless of type 1 and type 2 is less in plasma than in plasma Large numbers within the scalp low inhibition rate in the scalp Also depending on the amount of isoflavone the blood concentration is the same We dont even know if its going to go up Ill interpret it in a favorable way 500mg of a ridiculous amount of isoflavone every day Even if you eat it you can get up to 10 of the type 1 inhibition rate You can only look forward to it In reality it is not expected to reach this level There will be no tangible treatment effect with this number right Then how about a highly concentrated isoflavone Wouldnt it have a positive effect on hair loss If type 1 is suppressed side effects can occur Dont we need to use isoflavone If there is a hair loss specialist next to you its a night where I have a lot of questions to ask This cover story is written by DaMo member Please wash your hair 원문보기

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