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[Prescription Info] I would like to ask you about the late and mixed doses of adodot and pinasteride. (Scientific Approach)

5years ago
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Hello, I've been getting hair loss medicine for over 2 years since I was 27 years old.

At first, it started with one tablet a day of pinasteride, but it seemed to work at first

Even after six months, I couldn't stop losing my hair. What was unusual here was that the scalp smelled a lot of unique sebum.

So I changed it to Dutasteride to one tablet a day. I definitely felt my hair getting thicker.
(Finasterids inhibit DHT type 2, and dutasterids inhibit both types 1 and 2, where type 1 is usually distributed in sebaceous glands.)

But I took it for about 3 months, and the side effects were so bad (insomnia, brain forming, etc.) that I changed it to 1 tablet a week, and it was okay.

After about a year and a half, I did a lot of stress and self-defense at work, but my body was so tired.

Then I felt a little under the weather and after about a week I lost a lot of hair again.. But it doesn't smell like sebum right now.

I'm asking you a question here. Below, Dutasteride is referred to as a time-dependent inhibitor for type 2, according to ***,

So does that mean type 2 inhibition of dutasteride gets weaker over time?

So now, I'm going to reinforce the type 2 inhibition a little with 1 beat a week and the rest of the pinasterids, but please give me your opinion.

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Comparison of propoxia and dutasteride
(Inhibition mechanism of 5-alpha reductase 1,2 and drug human response parameters)

The interaction of dutasteride with 5-alpha reductase was tested at 37°C pH 7 with mouse experiments. This 5-alpha reductase inhibitor has already been known as a time-dependent inhibitor (reducing inhibitory capacity over time: why we should take it for life).

However, although ***dutasteride is a time-dependent inhibitor for 5-alpha reductase 2, it is a typical equilibrium autophagy for 5-alpha reductase 1. This phenomenon is the result of pinasteride, which is already used as a prostate treatment.

Inhibition of 5-alpha reductase by dutasteride competes with testosterone, with the K(i) value of Michaelis-Menten (enzyme and substrate reaction rate equation) being 0.3±0.02 nM.

The inhibition data for 5-alpha reductase 2 of dutasteride are consistent with a two-step mechanism. That is, K(i) is the dissociation constant of the enzyme and inhibitor reaction complex, and k(3) is the second rate constant.

The pseudo-bimolecular velocity constant (k(3)/K(i)) for dissociation after defects of dutasteride and 5-alpha reductase is 2.0±0.4×10(7) M(-1) sec(-1). The high affinity of dutasteride for 5-alpha reductase 2 for the defects of each other was dissociated only after dialysis at 4°C for about 7 days.

Inhibition of 5-alpha reductase 2 on dutasteride and finasteride inhibits the action of the enzyme with clear, irreversible structural modification, but 5-alpha reductase 1 is a typical reversible inhibitor.

Therefore, we can increase the inhibitory effect on 5-alpha reductase 1 as a drug human response parameter, so it can be said that dutasteride is more effective as a treatment for prostatic hyperplasia than finasteride.

Source: Biochem Pharmacol Vol 62, No 7, 933-942P October 1, 200

The contents of this post are based on the user's personal experience and public general information, and are not intended to advertise, promote, or encourage the use of certain medicines. Please consult a medical professional for the use of prescription drugs and treatment.

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