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[Finasteride] 프로페시아 특허 내용

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(19) 대한민국특허청(KR)
(12) 등록특허공보(B1)

(51) Int. Cl.6
A61K 31/58
A61K 7/06 (45) 공고일자 2003년06월09일
(11) 등록번호 10-0375083
(24) 등록일자 2003년02월24일
(21) 출원번호 10-1996-0701921 (65) 공개번호 특1996-0704555
(22) 출원일자 1996년04월15일 (43) 공개일자 1996년10월09일
번역문제출일자 1996년04월15일
(86) 국제출원번호 PCT/US1994/11507 (87) 국제공개번호 WO 1995/10284
(86) 국제출원일자 1994년10월11일 (87) 국제공개일자 1995년04월20일
(81) 지정국 국내특허 : 기네 오스트레일리아 바베이도스 불가리아 브라질 캐나다 체코 헝가리 일본 대한민국 스리랑카 마다가스카르 몽고 노르웨이 뉴질랜드 폴란드 루마니아 슬로바키아 우크라이나 미국 중국 에스토니아 그루지야 라이베리아 리투아니아 라트비아 슬로베니아 트리니다드토바고 우즈베키스탄 AP ARIPO특허 : 가나 감비아 케냐 레소토 말라위 수단 스와질랜드 우간다 짐바브웨
EA 유라시아특허 : 벨라루스 카자흐스탄 러시아 아르메니아 키르기즈 몰도바 타지키스탄
EP 유럽특허 : 핀랜드
OA OAPI특허 : 코트디브와르

(30) 우선권주장 08/138520 1993년10월15일 미국(US)
08/214905 1994년03월17일 미국(US)
(73) 특허권자 머크 앤드 캄파니 인코포레이티드
미국 뉴저지 07065 라웨이 이스트 링컨 애브뉴 126
(72) 발명자 글렌 제이. 검리
미합중국 뉴저지 07090 웨스트필드 페어아크리스 애비뉴 744
케이쓰 디. 커프맨
미합중국 뉴저지 07090 웨스트필드 에쥐우드 애비뉴450
엘리자베쓰 스토너
미합중국 뉴저지 07090 웨스트필드 이스트 듀들리 애비뉴 215
죠안 왈드스트레이처
미합중국 뉴저지 07076 스코취 플레인스 클리데스데일 로오드 75
(74) 대리인 이병호
심사관 : 휴-이영완
(54) 5-알파환원효소억제제를함유하는안드로겐성탈모증치료용약제학적조성물
요약
본 발명은 안드로겐성 탈모증의 치료를 필요로 하는 환자에게 피나스테라이드와 같은 5α-환원효소 2 억제제를 5mg/일 이하의 용량으로 투여하여 안드록겐성 탈모증을 치료 및/또는 전환시키고 모발 성장을 촉진시키는 방법 및 심상성 좌창, 지루 및 여성 조모증을 치료하는 방법에 관한 것이다.
명세서
본 발명은 제2형 5-α 환원효소 이소자임 억제제 화합물을 사용하여 남성형 대머리증을 포함하는 안드로겐성 탈모증을 치료하는 방법에 관한 것이다.
본 출원은 1993년 10월 15일에 출원된 미합중국 특허원 제08/138,520호의 일부 계속 출원이다.
발명의 배경
바람직하지 않은 특정한 생리학적 징후, 예를 들어 심상성 좌창, 지루, 여성 조모증, 여성 및 남성형 대머리증을 포함하는 안드로겐성 탈모증 및 양성 전립선 과형성증은 대사계에서 테스토스테론('T') 또는 유사한 안드로겐 호르몬의 과다한 축적에 의해 유발된 과안드로겐 자극에 기인한다. 과안드로겐 형성의 바람직하지 않은 결과에 대처하기 위한 화학요법제를 제공하려는 초기의 시도로, 바람직하지 않은 자체 호르몬 활성을 갖는 일부 스테로이드성 항안드로겐 물질이 발견되었다. 예를 들면, 에스트로겐은 안드로겐의 효과를 길항시킬 뿐만 아니라, 여성화 효과를 가지고 있다. 또한, 비-스테로이드성 항안드로겐 물질, 예를 들어 4'-니트로-3'-트리플루오로메틸이소부티르아닐라이드가 개발되었다[참조: Neri, et al., Endocrinol 1972, 91(2)]. 그러나, 이들은 호르몬 효과는 없을지몰라도, 수용체 부위에 대해 모든 천연 안드로겐 물질파 경쟁하는 관계로 남성 숙주 또는 여성 숙주의 남성 태아를 여성화시키는 경향이 있고/있거나 피드-백 효과를 개시하여 정소의 과자극을 유발한다.
일부 표적 기관(예: 전립선)에서 안드로겐 활성의 주요한 매개자는 테스토스테론-5α-환원효소의 작용에 의해 표적 기관에서 국소적으로 형성된 5α-디하이드로테스토스테론('DHT')이다. 테스토스테론-5α-환원효소의 억제제들은 이들 조직에서 과안드로겐 자극의 징후를 예방하거나 저하시킬 것이다[참조: 특히 Merk & Co., Inc.에게 양도되고, 1983년 3월 22일 허여된 미합중국 특허 제4,377,584호]. 피부 조직과 상호작용하는 제2형 5α-환원효소 이소자임이 특히 두피 조직에 존재하는 것으로 밝혀졌다[참조: G. Harris, et al., Proc. Natl Acad. Sci. USA. Vol. 89, pp. 10787-10791(Nov. 1992)]. 피부 조직에서 주로 작용하는 이소자임은 통상적으로 5α-환원효소 1(또는 제1형 5α-환원효소)로 명명되어 있으며, 전립선 조직내에서 주로 작용하는 이소자임은 5α-환원효소 2(또는 제2형 5α-환원효소)로 명명되어 있다.
상표명 로 Merck & Co., Inc.에서 시판하는 피나스테라이드(17β-(N-3급-부틸카바모일)-4-아자-5α-안드로스트-1-엔-3-온)는 5α-환원효소 2의 억제제이며, 과안드로겐 질환의 치료에 유용한 것으로 공지되어 있다[참조: 미합중국 특허 제4,760,071호]. 피나스테라이드는 양성 전립선 과형성증의 치료용으로 미합중국 및 세계적으로 시판되고 있다. 안드로겐성 탈모증 및 전립선암의 치료에서 피나스테라이드의 용도가 또한 하기 문헌에 기술되어 있다(참조: 1988년 10월 5일 공고된 EP 제0 285,382호; 1988년 10월 5일 공고된 EP 제0 285,383호; 캐나다 특허 제1,302,277호 및 캐나다 특허 제1,302,276호). 상기 인용된 문헌에 예시된 구체적인 투여량은 5mg 내지 2000mg/환자/일이다.
여성 및 남성형 대머리증을 포함하는 안드로겐성 탈모증, 및 기타 과안드로겐 질환의 치료에 있어서, 환자에게 가능한한 최소량의 약제학적 화합물을 투여하여 치료적 효능을 유지하는 것이 바람직할 것이다. 본 발명자들은 놀랍게도, 예상외로 1일당 저용량의 제2형 5α-환원효소 억제제가 안드로겐성 탈모증 치료에 특히 유용함을 밝혀내었다. 게다가, 1일당 저용량의 5α-환원효소 2 억제제는 심상성 좌창, 지루, 여성 조모증 및 다낭포성 난소 증후군과 같은 과안드로겐 질환의 치료에도 특히 유용할 수 있다.
발명의 상세한 설명
본 발명은 치료를 필요로 하는 환자에게 5α-환원효소 2 억제제를 5mg/1일 이하의 용량으로 투여하는 것을 포함하는, 안드로겐성 탈모증을 치료하고/하거나 반전시키고 모발 성장을 촉진하는 방법, 및 심상성 좌창, 지루 및 여성 조모증을 치료하는 방법에 관한 것이다. 본 발명의 한가지 양태로서, 5α-환원효소 2 억제제는 0.01 내지 3.0mg/일의 용량으로 투여된다. 이 양태의 한가지 부류로서, 5α-환원효소 2 억제제는 0.05 내지 1.0mg/일의 용량으로 투여되며, 이 양태의 아류로서 5α-환원효소 2 억제제는 약 0.05 내지 0.2mg/일의 용량으로 투여된다. 이러한 아류의 예는 약 0.05, 0.1, 0.15 및 0.2mg/일의 용량이다. 아류의 용량의 예는 0.05 및 0.2mg/일이다. 5α-환원효소 2의 억제제인 화합물은 하기 실시예 3에 기술된 검정 방법을 사용하여 측정할 수 있다.
본 발명의 두번째 양태로서, 안드로겐성 탈모증의 치료 방법은 일반식(I)의 5α-환원효소 2 억제제 화합물 또는 이의 약제학적으로 허용되는 염의 투여하는 것을 포함한다:

상기식에서,
R1은 수소, 메틸 또는 에틸이고,
R2는 하나 이상의 탄소수 1 내지 2의 저급 알킬 치환체 및/또는 하나 이상의 할로겐(Cl, F 또는 Br) 치환체를 함유하거나 함유하지 않는 탄소수 1 내지 12의 직쇄 및 측쇄 알킬 또는 모노사이클릭 아릴중에서 선택된 탄화수소 라디칼이며,
R'는 수소 또는 메틸이고,
R'는 수소 또는 β-메틸이며,
R''는 수소, α-메틸 또는 β-메틸이다.
이러한 제2 양태의 한가지 부류로서, 5α-환원효소 2 억제제 화합물은 일반식(II)의 화합물 또는 이의 약제학적으로 허용되는 염이다.

상기식에서,
R1은 수소 또는 메틸이고,
R3은 탄소수 4 내지 8의 측쇄 알킬이다.
본 발명에 사용될 수 있는 대표적인 화합물은 다음과 같다:
17β-(N-3급-부틸카바모일)-4-아자-5-α-안드로스트-1-엔-3-온,
17β-(N-이소부틸카바모일)-4-아자-5-α-안드로스트-1-엔-3-온,
17β-(N-3급-옥틸카바모일)-4-아자-5α-안드로스트-1-엔-3-온,
17β-(N-옥틸카바모일)-4-아자-5α-안드로스트-1-엔-3-온,
17β-(N-1,1-디에틸부틸카바모일)-4-아자-5α-안드로스트-1-엔-3-온,
17β-(N-네오펜틸카바모일)-4-아자-5α-안드로스트-1-엔-3-온,
17β-(N-3급-아밀카바모일)-4-아자-5α-안드로스트-1-엔-3-온 및
17β-(N-3급-헥실카바모일)-4-아자-5α-안드로스트-1-엔-3-온, 및
상술된 각각의 화합물에서 4-질소가 메틸 또는 에틸 라디칼로 치환된 상응하는 화합물.
또한, 대표적인 화합물에는 메틸, 에틸, 프로필, i-프로필, 부틸, 페닐에 의해 대체된 N-측쇄 알킬 치환체, 2, 3 또는 4 톨릴, 크실릴, 2-브로모 또는 2-클로로페닐, 2-6-디클로로 또는 2,6-디브로모페닐 치환체를 갖는 상술된 모든 화합물이 포함된다.
상술된 일반식(I) 및 일반식(II)의 화합물은 본 기술 분야에 공지되고, 예를 들어 미합중국 특허 제4,760,071호, EP 제0 285,382호 및 EP 제0 285,383,호에 기술되어 있는 공정에 따라 합성할 수 있다. 화합물 피나스테라이드는 Merck & Co., Inc.로부터 처방 약제로서 현재 시판되고 있다. 피나스테라이드의 합성방법은 미합중국 특허 제4,760,071호에 기술되어 있다. 피나스테라이드의 추가의 합성 방법은 문헌[참조: Synthetic Communications, 30(17), p. 2683-2690 (1990)]에 기술되어 있다.
본 발명의 목적은 5α-환원효소 2 억제제를 5mg/일 이하의 용량, 및 특히 약 0.01 내지 3.0mg/일, 및 더욱 특히 0.05 내지 1mg/일의 용량으로 전신, 경구, 비경구 또는 국소 투여하여 남성형 대머리증 및 여성형 대머리증을 포함한 안드로겐성 탈모증, 심상성 좌창, 지루, 여성 조모증 및 다낭포성 난소 증후군과 같은 과안드로겐 질환을 치료하는 방법을 제공하는 것이다. 또한, 본 발명은 약 0.05 내지 0.2mg/일의 용량 및 특히 약 0.05, 0.1, 0.15 및 0.2mg/일의 용량으로 예시된다. 본 발명의 용량예는 0.05 및 0.2mg/일이다. 용어 '안드로겐성 탈모증의 치료'는 안드로겐성 탈모증의 억제 및/또는 반전 및 모발 성장의 촉진을 포함한다. 또한, 남성형 대머리증을 포함하는 안드로겐성 탈모증의 치료를 위해 5α-환원효소 2 억제제, 예를 들어 피나스테라이드를 5mg/일 이하의 용량으로 미녹시딜 또는 이의 약제학적으로 허용되는 염과 같은 칼륨 채널 개방제와 배합 사용할 수 있다. 5α-환원효소 2 억제제 및 칼륨 채널 개방제는 모두 국소 적용되거나, 각각의 제제를 상이한 투여 경로, 예를 들어 5α-환원효소 2 억제제를 경구 투여하고 칼륨 채널 개방제를 국소 투여하여 제공할 수 있다.
또한, 본 발명의 목적은 본 발명의 신규한 치료 방법에 사용하기 적합한 전신, 경구, 비경구 및 국소용 약제학적 제제를 제공하는 것이다. 상술된 과안드로겐 질환의 치료에 사용하기 위한 활성 성분으로서 5α-환원효소 2 억제제를 함유하는 조성물은 전신 투여를 위해 통상적인 약물 운반체중의 다양한 치료 용량 형태로 투여될 수 있다. 예를 들면, 화합물은 정제, 캅셀제(서방성 및 방출지속성 제형을 포함), 환제, 분제, 과립제, 엘릭실제, 틴크제, 용액제, 현탁제, 시럽제 및 유제와 같은 경구 투여 형태로 투여될 수도 있다. 마찬가지로, 화합물은 정맥내(일시주사 및 주입 모두), 복강내, 피하, 교합이 있거나 없는 국소, 또는 근육내 투여 형태, 약제학적 분야의 통상의 지식을 가진 자에게 공지된 모든 이용 형태의 제형으로 투여될 수도 있다. 경구 투여의 경우, 예를 들어 조성물은 치료하고자 하는 환자의 증상에 따른 용량 조절을 위해 0.01, 0.05, 0.1, 0.2, 1.0, 2.0 및 3.0mg의 활성 성분을 함유하는 정제 형태(기록 또는 비기록 제제)로 제공될 수 있다.
남성형 대머리증을 포함하는 안드로겐성 탈모증, 심상성 좌창, 지루 및 여성 조모증의 치료를 위해 5α-환원효소 2 억제제 화합물은 활성 화합물을 국소 투여에 적합한 약제학적으로 허용되는 담체와 함께 배합시켜서 만든 약제학적 조성물의 형태로 투여될 수 있다. 국소용 약제학적 조성물은 예를 들어, 피부에 적용하기에 적합한 용액, 크림, 연고, 겔, 로숀, 샴푸 또는 에어로솔 제형일 수 있다. 본 발명의 치료 방법에 유용한 국소용 약제학적 조성물은 약제학적으로 허용되는 담체와 혼합된 약 0.001% 내지 0.1%의 활성 화합물을 포함할 수 있다.
유리하게는, 본 발명의 화합물은 1일당 1회의 용량으로 투여될 수 있거나, 1일 총복용량이 1일당 2, 3 또는 4회로 분복될 수도 있다. 본 발명의 화합물은 적합한 비강 투여용 운반체를 국소적으로 사용함으로써 비강 투여 형태, 또는 본 기술 분야의 통상의 지식을 가진 자에게 공지된 경피 패치의 형태를 사용하는 경피 경로를 통해 투여될 수 있다. 경피 전달 시스템의 형태로 투여하기 위해서, 용량 투여는 당연히 용량요법 전반에 걸쳐 간헐적이기 보다는 연속적이 될 것이다. 또한, 본 발명의 화합물은 코코아 버터, 글리세린젤라틴, 수소화 식물성 오일, 여러가지 분자량의 폴리에틸렌 글리콜과 폴리에틸렌 글리콜의 지방산 에스테르와의 혼합물과 같은 기재를 사용한 좌제로서 전달될 수도 있다.
본 발명의 화합물을 사용하는 용량요법은 환자의 유형, 종류, 나이, 체중, 성별 및 의학적 상태; 치료하고자 하는 질환의 중증도; 투여 경로; 환자의 신장 및 간장 기능 및 사용하는 특정 화합물등 다양한 인자에 따라 선택된다. 통상의 지식을 가진 주치의 또는 전문가는 질환의 진행을 예방, 길항, 억제 또는 반전시키는데 필요한 유효량의 약물을 용이하게 결정 및 처방할 수 있다. 효능은 얻되 독성이 없는 범위내의 약물농도를 얻는 최적의 처방을 위해서는 표적 부위에 대한 약물 이용율의 속도론에 근거한 처방요법이 요구된다. 이는 약물의 분포, 평형 및 제거를 고려한 것이다.
본 발명의 방법에 있어서, 본원에 상세히 기술된 5α-환원효소 2 억제제 화합물은 활성 성분을 형성할 수 있으며, 목적하는 투여 형태, 즉, 경구용 정제, 캅셀제, 엘릭실제, 시럽제 등을 고려하여 통상의 약제실무에 부합하도록 적절히 선택된 적합한 약제학적 희석제, 부형제 또는 담체(총칭하여 본원에서는 '담체' 물질로 칭함)와 혼합하여 통상적으로 투여된다.
예를 들어 정제 또는 캅셀제의 형태로 경구 투여할 경우, 활성 약물 성분을 경구 무독성의 약제학적으로 허용되는 불활성 담체(예: 에탄올, 글리세롤, 물 등)와 배합할 수 있다. 본 발명의 생성물을 함유하는 캅셀제는 본 발명의 활성 화합물을 락토오즈 및 마그네슘 스테아레이트, 칼슘 스테아레이트, 전분, 활석, 또는 기타 담체와 혼합하고 혼합물을 젤라틴 캅셀내에 넣어서 제조할 수 있다. 정제는 활성 성분을 통상의 정제화 성분(예: 인산 칼슘, 락토오즈, 옥수수 전분 또는 마그네슘 스테아레이트)과 혼합하여 제조할 수 있다. 게다가, 바람직하거나 필요한 경우, 적합한 결합제, 윤활제, 붕해제 및 착색제를 혼합물에 또한 혼입할 수 있다. 적합한 결합제에는 전분, 젤라틴, 천연 당(예: 글루코즈 또는 베타-락토오즈), 옥수수 감미료, 천연 및 합성 검(예• 아카시아, 트라가칸트 또는 나트륨 알기네이트, 카복시메틸셀룰로오즈, 폴리에틸렌 글리콜, 왁스 등)이 포함된다. 이들 용량 형태에 사용되는 윤활제에는 나트륨 올레에이트, 나트륨 스테아레이트, 마그네슘 스테아레이트, 나트륨 벤조에이트, 나트륨 아세테이트, 염화나트륨 등이 포함된다. 붕해제에는 전분, 메틸 셀룰로오즈, 한천, 벤토나이트, 잔탄 검 등이 포함되지만, 이로써 제한되는 것은 아니다.
액제는 합성 및 천연 검(예: 트라가칸트, 아카시아, 메틸-셀룰로오즈 등)과 같은 적절한 향기의 현탁화제 또는 분산제중에서 형성한다. 사용될 수 있는 기타 분산제는 글리세린 등을 포함한다. 비경구 투여의 경우, 멸균 현탁액 및 용액이 바람직하다 정맥내 투여가 바람직할 경우, 일반적으로 적합한 보존제를 함유하는 등장성 제제가 사용된다.
활성 약물 성분을 함유하는 국소용 제제를 본 기술 분야에 공지된 다양한 담체 물질, 예를 들어 알콜, 알로에 베라 겔, 알란토인, 글리세린, 비타민 A 및 E 오일, 광유, 프로필렌 글리콜, PPG2 미리스틸 프로피오네이트 등과 혼합하여 예를 들어 알콜 용액, 국소용 세척제, 세안 크림, 피부 겔, 피부 로숀, 및 샴푸를 크림 또는 겔 제형으로 형성할 수 있다[참조: EP 제0 285,382호].
또한, 본 발명의 화합물은 리포좀 전달 시스템의 형태, 예를 들어 작은 단일막 소포체, 거대한 큰 단일막 소포체 및 다중막 소포체로 투여할 수 있다. 리포좀은 다양한 인지질, 예를 들어 콜레스테롤, 스테아릴아민 또는 포스파티딜콜린으로부터 형성될 수 있다.
또한, 본 발명의 화합물은 화합물 분자가 결합되는 개개 담체로서 단클론 항체를 사용하여 전달할 수 있다. 또한, 본 발명의 화합물은 목표의 약물 담체로서 가용성 중합체와 커플링시킬 수 있다. 이러한 중합체는 폴리비닐피롤리돈, 피란 공중합체, 폴리하이드록시프로필메타크릴아미드페놀, 폴리하이드록시에틸아스파르트아미드페놀, 또는 팔미토일 잔기로 치환된 폴리에틸렌옥사이드폴리리신을 포함할 수 있다. 게다가, 본 발명의 화합물은 약물의 방출제어를 달성하는데 유용한 생분해성 중합체 부류, 예를 들어 폴리락트산, 폴리엡실론 카프롤락톤, 폴리하이드록시부티르산, 폴리오르토에스테르, 폴리아세탈, 폴리디하이드로피란, 폴리시아노아크릴레이트 및 하이드로겔의 가교-결합된 또는 양친매성 블록 공중합체와 커플링시킬 수 있다.
하기 실시예는 본 발명을 예시한 것이며, 본원에 첨부된 특허 청구의 범위에 기재된 본 발명을 제한하고자 하는 것은 아니다.
실시예 1
피나스테라이드는 '형태 I' 및 '형태 II'로 명명된 두개의 독특한 다형성 결정 형태로 존재함이 공지되어 있다. 형태 I은 5mg의 정제로서 시판된 형태의 피나스테라이드( )이다.
피나스테라이드 형태 I은 피나스테라이드를 빙초산(약 100mg/ml)중에 용해시키고, 교반시키면서 물의 중량%가 84% 이상이 될 때까지 물을 가하여 제조할 수 있다. 생성된 고체 상을 여과하여 수거하고, 진공하에 약 50℃에서 건조시킨다. 생성된 형태 I의 특징은 밀폐된 컵중에서 20℃/분의 속도로 가열한 시차 주사 열량측정(DSC) 곡선이 약 232℃의 피크 온도에서 소량의 흡열을 나타내고 약 11J/gm의 회합열에서 약 223℃의 외삽된 개시 온도를 나타내며, 약 261℃의 피크 온도에서 주된 융해 흡열을 나타내고 약 89J/Igm의 회합열에서 약 258℃의 외삽된 개시 온도를 나타낸다. X-선 분말 회절 패턴은 6.44, 5.69, 5.36, 4.89, 4.55, 4.31, 3.85, 3.59 및 3.14의 d-공간에 의해 특징지워진다. FT-IR 스펙트럼은 3431, 3237, 1692, 1666, 1602 및 688cm-1에서 밴드를 나타낸다. 25℃에서 물 및 사이클로헥산에서의 용해도는 각각 0.05+0.02 및 0.27+0.05mg/gm이다. 또한, 피나스테라이드의 형태 1은 무수(H2O
(1mg/ml) 에틸 아세테이트 및 이소프로필 아세테이트로부터 재결정화에 의해 제조할 수 있다. 분리된 고체는 약 50℃에서 진공하에 건조시키고, 상기 제공된 것과 동일한 물리적 특성 데이타를 가진다.
실시예 2
피나스테라이드의 형태 II는 피나스테라이드를 빙초산(약 100mg/ml)중에 용해시키고, 교반시키면서 물의 중량%가 약 75%(80%를 초과하지 않음)가 될 때까지 물을 가하여 제조할 수 있다. 생성된 고체 상을 여과하여 수거하고, 진공하에 약 100℃에서 건조시킨다. 생성된 형태 II의 특징은 밀폐된 컵중에서 20℃/분의 속도로 가열한 DSC 곡선이 약 261℃의 피크 온도에서 단일 융해 흡열을 나타내고, 약 89J/gm의 회합열에서 약 258℃의 외삽된 개시 온도를 나타낸다. X-선 분말 회절 패턴은 14.09, 10.36, 7.92, 7.18, 6.40, 5.93, 5.66, 5.31, 4.68, 3.90, 3.60 및 3.25의 d-공간에 의해 특징지워진다. FT-IR 스펙트럼은 3441, 3215, 1678, 1654, 1597, 1476 및 752cm-1에서 밴드를 나타낸다. 25℃에서 물 및 사이클로헥산에서의 용해도는 각각 0.16+0.02 및 0.42+0.05mg/gm이다. 또한, 퍼나스테라이드의 형태 II는 물 ml당 2 내지 30mg을 함유하는 에틸 아세테이트 및 물 ml당 2 내지 15mg을 함유하는 이소프로필 아세테이트로부터 재결정화에 의해 제조할 수 있다. 분리된 고체는 약 80℃에서 진공하에 건조시키고, 상기 제공된 것과 동일한 물리적 특성 데이타를 가진다. 또한, 형태 II는 형태 I을 약 150℃ 이하로 가열하고, 약 1시간 동안 유지시킨 다음, 실온으로 다시 냉각시켜 제조할 수 있다. 이러한 방법으로 제조된 형태 II는 상기 제공된 것과 동일한 물리적 특성 데이타를 가진다.
실시예 3
사람 전립선 5α-환원효소의 제조방법
동결 분쇄기를 사용하여 사람 조직 샘플을 미분쇄하고, Potter-Elvehjem 균질화기를 사용하여 40mM 인산칼륨(pH 6.5), 5mM 황산마그네슘, 25mM 염화칼륨, 1mM 페닐메틸설포닐 플루오라이드, 0.25M 수크로즈를 함유하는 1mM 디티오트레이톨(DTT)에서 균질화시킨다. 조 핵 펠렛은 균질물을 15분 동안 1,500 x g으로 원심분리하여 제조한다. 조 핵 펠렛을 2회 세척하고, 완충액 2 용적중에 재현탁시킨다. 글리세롤을 가하여 20%의 최종 농도까지 펠렛을 재현탁시킨다. 효소 현탁액을 -80℃에서 분획으로 냉동시킨다. 이러한 조건하에 보관할 경우, 전립선 환원효소는 4개월 이상동안 안정하다.
5α-환원효소 검정
제II형 5α-환원효소에 대한 반응 혼합물은 pH 5.5의 40mM 나트륨 시트레이트, 0.3μM[7-3H]-테스토스테론, 1mM 디티오트레이톨 및 500μM NADPH를 최종 용적 100μl중에 포함한다. 통상적으로, 50 내지 100μg의 전립선 균질물을 가함으로서 검정을 시작하여 37℃에서 배양한다. 10 내지 50분 후, 각각 10μg의 DHT및 T를 함유하는 70% 사이클로헥산과 30% 에틸 아세테이트의 혼합물 250μl로 추출하여 반응을 급냉시킨다. 에펜도르프 마이크로퓨지에서 14,000rpm으로 원심분리하여 수성 층과 유기층을 분리한다. 유기층에 대해 통상의 상 HPLC(70% 사이클로헥산:30% 에틸 아세테이트를 1ml/분으로 평형화시킨 10cm 왓트만 파티실 5 실리카 컬럼; 체류시간: DHT, 6.8 내지 7.2분; 안드로스탄디올, 7.6 내지 8.0분; T, 9.1 내지 9.7분)를 수행한다. HPLC 시스템은 히타치 모델 655A 오토샘플러, 어플라이드 바이오시스템즈 모델 757 가변 자외선 검출기 및 레디오마틱 모델 A120 방사능 분석기가 장착된 워터스 모델 680 그레디언트 시스템으로 구성된다. T에서 DHT로의 전환은, 1 용적의 Flo Scint 1(레디오마틱)과 HPLC 유출물을 혼합시킴으로써 방사능 유동 검출기를 사용하여 모니터한다. 상술된 조건하게, DHT의 생성은 적어도 25분 동안 선형이다. 사람 전립선 생성에 따라 관찰된 유일한 스테로이드는 T, DHT 및 안드로스탄디올이다.
억제 연구
화합물을 100% 에탄올중에 용해시킨다. IC50값은 대조군의 효소 활성을 50%까지 저하시키는데 요구되는 억제제의 농도를 나타낸다. 억제제의 농도가 0.1 내지 1000nM로 다양하게 6 포인트 적정을 사용하여 IC50 값을 측정한다.
실시예 4
모발 성장을 측정하기 위한 확대촬영 방법 및 원형 촬영 방법
A. 확대 촬영 방법
위치: ID 카드
모발계수 목적 부위
장비: 필름: 코닥-T-맥스, 24장, 각각 동일한 유제 로트 번호
카메라: 니콘(Nikon) N-6000
렌즈: 니코르(Nikkor) 60mm f2.8
플래쉬: 니콘 SB-21B 매크로플래쉬
기구: 핀트 기구
촬영 방법:
이러한 임상적 촬영에 있어서, 허용되는 유일한 변수는 모발수이다. 필름 유제, 광선, 프레임, 노출 및 재현율은 일정하게 유지한다.
1. 환자의 모발계수 부위는 다음과 같이 준비한다:
시판용 표식 장치를 사용하거나 수동(바늘 및 잉크)으로 머리 꼭대기의 모발이 없는 중심점 전방의 모발이 없는 앞 가장자리에 시험 초기에 작은(∼1mm) 점 표식을 한다. 모발이 없는 부위의 앞 가장자리의 표식 중심에서 약 1/4 인치 크기(∼2mm) 부위의 모발을 잘라낸다. 테이프를 사용하여 촬영하고자 하는 부위로부터 잘라낸 모발을 제거한다. 잘라낸 모발을 용이하게 제거하기 위해 압축된 공기 및/또는 에탄올 와이프가 사용될 수 있다.
2. 확대도: 제공된 각 렌즈는 1:1.2의 고정된 재현율을 가진다.
조리개: 매 촬영을 f/22에서 수행한다.
필름: T-맥스 100(24장)을 사용한다.
3. 환자의 모발계수 목적 부위. 3회 노출(-2/3, 0 및 +2/3 f-정지).
숙련가는 사진 인화에 대한 투명도를 제시하고, 펠트 팁 펜을 사용하여 각각의 가시 모발에 대해 흑색 점을 찍는다. 이어서, 컴퓨터를 이용한 상 분석 방법을 사용하여 점 지도 투명도를 계산한다.
시간에 따른 블라인딩을 확인하기 위해 시험 부위, 시찰 번호 및 환자 할당 번호에 상응하는 랜덤 번호로 사진을 코드화한다. 6개월 후에, 기준선과 6개월 후의 사진을 계산하고, 중간 분석을 위해 데이타를 분석한다. 12 개월 후에, 기준선, 6개월 및 12개월 후의 사진을 계산하고, 주요한 최종점에 대해 데이타를 분석한다.
또한, 모발 성장을 측정하는 방법론은 문헌[참조: Olsen, E.A. and DeLeng, E., J. American Academy of Dermatology, Vol, 23, p. 470(1990)]에 기술되어 있다.
B. 원형 촬영 방법
위치: 색 카드/환자 Id
원형 촬영
장비: 필름: 코다크롬 KR-64, 24장, 각각의 동일한 유제 로트 번호
카메라: 니콘 N-6000
렌즈: 니코르 60mm f2.8
플래쉬: 니콘 SB-23
촬영 방법
이러한 임상적 촬영에 있어서, 허용되는 유일한 변수는 원형 부위의 외경이다. 부위와 무관한 모든 것(옷, 가구, 벽 등)을 촬영되는 현장에서 제거한다.
1. 환자는 고정된 위치(제공된 정위 장치로 결정됨)에서 머리에서 모발을 잘라내기 전에 원형 촬영을 수행할 것이다. 환자 머리상의 모발을 일정하게 위치시켜 모발이 없는 부위를 가리지 않게 한다.
2. 확대도 : 제공된 각각의 렌즈는 1:6의 고정된 재현율을 가진다.
조리개: 매 촬영을 f/11에서 수행한다.
필름: 코다크롬(24장)을 사용한다.
3. 환자의 원형 촬영. 보정 0에서 3회 노출.
상술된 방법을 사용하여, 피나스테라이드를 포함하는 5α-환원효소 2 억제제를 환자당 1일 5mg 이하의 용량, 예를 들어 1mg/일 또는 0.2mg/일의 용량으로 투여하면, 안드로겐성 탈모증의 치료에 유용하고 이러한 질환이 있는 환자의 모발 성장을 촉진시킴을 알수 있다.
실시예 5
또 다른 시험에서, 남성형 대머리증을 앓고 있는 남자에게 피나스테라이드를 0.2mg/일, 1.0mg/일 및 5.0mg/일의 용량으로 6주 동안 경구 투여한다. 이 시험의 결과는 시험 참가자의 두피 조직에서 DHT 함량이 현저히 감소함을 보여주었다.
(57) 청구의 범위
청구항 1
약제학적으로 허용되는 담체와 함께 17β-(N-3급-부틸카바모일)-4-아자-5α-안드로스트-1-엔-3-온을 0.05 내지 3.0mg의 단위 용량으로 함유하는 안드로겐성 탈모증의 치료에 유용한 경구투여용 약제학적 조성물.
청구항 2
제1항에 있어서, 안드로겐성 탈모증이 남성형 대머리증인 약제학적 조성물.
청구항 3
제1항에 있어서, 17β-(N-3급-부틸카바모일)-4-아자-5α-안드로스트-1-엔-3-온이 1mg의 단위 용량으로 존재하는 약제학적 조성물.
청구항 4
제2항에 있어서, 17β-(N-3급-부틸카바모일)-4-아자-5α-안드로스트-1-엔-3-온이 1mg의 단위 용량으로 존재하는 약제학적 조성물.
청구항 5
제1항에 있어서, 약제학적으로 허용되는 정제화 성분과 함께 17β-(N-3급-부틸카바모일)-4-아자-5α-안드로스트-1-엔-3-온을 0.5 내지 3.0mg의 단위용량으로 함유하는 정제 형태의 안드로겐성 탈모증의 치료용 약제학적 조성물.
청구항 6
제5항에 있어서, 안드로겐성 탈모증이 남성형 대머리증인 정제 형태의 약제학적 조성물.
청구항 7
제5항에 있어서, 17β-(N-3급-부틸카바모일)-4-아자-5α-안드로스트-1-엔-3-온이 1mg의 단위 용량으로 존재하는 정제 형태의 약제학적 조성물.
청구항 8
제6항에 있어서, 17β-(N-3급-부틸카바모일)-4-아자-5α-안드로스트-1-엔-3-온이 1mg의 단위 용량으로 존재하는 정제 형태의 약제학적 조성물.
청구항 9
제7항에 있어서, 정제화 성분이 인산칼슘, 락토오즈, 옥수수 전분 및 마그네슘 스테아레이트로부터 선택되는 정제 형태의 약제학적 조성물.
청구항 10
제9항에 있어서, 정제화 성분이 락토오즈 및 마그네슘 스테아레이트로부터 선택되는 정제 형태의 약제학적 조성물.
청구항 11
제9항에 있어서, 하나 이상의 결합제, 윤활제, 붕해제 및 착색제를 추가로 포함하는 정제 형태의 약제학적 조성물.
청구항 12
제11항에 있어서, 결합제가 전분, 젤라틴, 천연 당, 옥수수 감미료, 검, 카복시메틸 셀룰로오즈, 폴리에틸렌 글리콜 및 왁스로부터 선택된 정제 형태의 약제학적 조성물.
청구항 13
제12항에 있어서, 결합제가 전분 및 젤라틴으로부터 선택되는 정제 형태의 약제학적 조성물.
청구항 14
제11항에 있어서, 윤활제가 나트륨 올레에이트, 나트륨 스테아레이트, 마그네슘 스테아레이트, 나트륨 벤조에이트, 나트륨 아세테이트 및 염화나트륨으로부터 선택되는 정제 형태의 약제학적 조성물.
청구항 15
제14항에 있어서, 윤활제가 마그네슘 스테아레이트인 정제 형태의 약제학적 조성물.
청구항 16
제11항에 있어서, 붕해제가 전분, 메틸 셀룰로오즈, 한천, 벤토나이트 및 잔탄 검으로부터 선택되는 정제 형태의 약제학적 조성물.
청구항 17
제16항에 있어서, 붕해제가 전분인 정제 형태의 약제학적 조성물.


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    Hair Transplant Photos & Reviews

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    포토후기 이미지
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    Busan Grow House

    early 30s / M-shape / Non-cut / 2500 mother transplant / 6 monthsI got counseling from several places in Busan and conducted it at Centum Grow Clinic I like the forehead line, and I am satisfied that the director and staff explained and cared for all the troubles that occur after surgery. It's not as full as I thought, so I'm half worried and half excited, but I'm satisfied with my current condition I'm planning to manage it while hoping it gets more packed.

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    포토후기 이미지
    모프로의원
    Mopro Clinic

    I brought a picture of my 12 months old! I went to the hospital to see after a year, and the director said thank you for raising me well.. It's something I should be more thankful for!!Kauric braces are good, so it's my first time putting my bangs down in my life. And if I don't tell anyone around me, no one knows I've transplanted it. That's how natural it is. I recommend Mopro Clinic for Hair Transplant.[Laughing]!

    조회수 184
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    모원성형외과의원
    MO.1 plastic surgery

    After retirement, I tend to adjust to life, manage my own and exercise steadily. I meet people often, too. But when I looked at my first family photo after retirement, my wide forehead looked more prominent than I thought. Since then, I've been seriously thinking about Hair Transplant.Is it right to make investments like this at this age at first? I also had that thought. But my family has worked hard so far, so they encouraged me to think of it as a retirement gift and try it. After hearing that, I changed my mind and looked for various reviews and received counseling. There were more people who had similar concerns to me than I thought. I was worried about not only my forehead but also my eyebrows, so I first looked at where I could transplant my hair and eyebrows together and most of all, I found out where the results came out naturally.After comparing several places, I chose the shrine MO.1 plastic surgery. The location was easy, but the design was the most satisfactory, and the most impressive was the use of micro-high magnification magnification equipment during surgery. I heard that it is a high-level enlargement equipment used for micro-surgery in university hospitals, but I thought that I could proceed more elaborately, especially in delicate areas such as eyebrows. After the consultation, I set the design and listened to the explanation of how the surgery was done once again before deciding on the surgery and booking it for the earliest possible date. And I finally had surgery today. I proceeded with a no-cutting non-cut method. Even though I retired, I had to keep meeting people, so I wanted a way for the collection to recover quickly and be less noticeable, but there was little pain than I thought, so my postoperative satisfaction was higher.The family's response was also good. It's the day, so I'm just expecting how it'll be filled, but I felt good when my family told me that it went well. Like the hairline, I'm looking forward to it because the eyebrow part looks really good. I was told that it naturally subsides over time, although there is a little redness left because it is right after surgery. Thank you to Director Jung Jae-hong for the operation well and the MO.1 plastic surgery staff for taking care of it carefully. I'll take good care of it in the future, watch the progress, and leave a review a few months later.

    조회수 196
    댓글 1
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    한나이브모발이식센터
    Hannaeve plastic surgery

    Hello, I'm finally leaving a review of the results for a year after surgery.As I wrote in the title, I created something out of nothing!I'm posting the pictures I've taken while going to the hospital.If you look at the preoperative pictureMy hair was in my mid to late 40s.The top of the head came off.MJ was coming up In the picture I took for four months It all fell out in the dark ages and then started to come back up.In the final year, all I can say is that it's just amazing. It feels new to continue like this.I'm not a non-hair loss person, but for me, more than anyone else's surgeryI like how I look.Don't lose your courage and try Hair Transplant.Thank you to the director of the Hannaeve plastic surgery who did well in the surgery, the kind staff and the manager every time I went.Now that I'm used to taking hair loss medicine, I'll watch my hair again.Thank you. Director Son Hyung-bin of Hannaeve plastic surgery, I highly recommend it. 

    조회수 263
    댓글 0
    포토후기 이미지
    모나라피부과의원
    MONARA dermatology clinic

    It's already been eight months since I received the Hair Transplant from Director Kim Dae-woo.It's been 8 months and my hair is fullWhenever I look in the mirror, I'm happy with how I've changed, but thanks to the compliments from people around me These days, I'm full of confidence wherever I go and I'm having a lot of fun every day.When I first decided to operate, I hesitated most about whether it would be effective at the age of 60. However, eight months have passed since Kim Dae-woo's words, which were convinced that it was possible enough since counseling, so don't worry, I think it's proven to be a perfect reality, so I'm deeply grateful for the director's perspective and skills once again.Now, looking at the heads that are completely settled down, I'm sure that age is not a stumbling block for Hair Transplant in their 60s, but the answer is to start as soon as possible. If there are people like me who are hesitant because of their age, I would like to confidently recommend it again this time to trust Director Kim Dae-woo and take a step forward.

    조회수 194
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    연세모벨르의원 종로본점
    The Jongno Headquarters of the Yonsei Mobel House

    I used to take medication for about 6 months because of hair loss in my early 20s, but I stopped because I didn't feel much of a crisis at the time... I regret taking it regularly Since then, it seems to have progressed gradually over time, so I recently received transplant counseling to receive medicine prescriptions.As a result of the treatment, I heard that about 4,000 hair transplants are needed based on the current condition. Considering the current state of hair in the occipital region and the possibility of additional transplants in the future, I was recommended to transplant about 2,000 hairs mainly on the hairline rather than 4,000 hairs at a timeAccording to the doctor's explanation, it is more realistic to consider transplanting the front line first and then considering additional transplants while looking at the progress and the condition of the larynx.Personally, I was a little shocked because it was progressing more than I thought, but the consultation itself didn't feel like I was recommending surgery too much, and it was very helpful because you explained it in consideration of the condition of the occipital region.It is a hospital that is satisfied overall because of its meticulous treatment and delicate counseling.If you are in your early 30s or are considering a transplant like me, it would be okay to go and get counseling.It's been about a week, but I'm satisfied and I'm considering a second transplant later, so I decided to do the injection treatment at the same time for 6 months to a year.I'll bring back the progress of the process in the future.

    조회수 171
    댓글 0
    포토후기 이미지
    모엠의원
    MOEM Clinic

    I'm so proud to have Hair Transplant, which has been a long-cherished dream.I'm so satisfied because it was decided after a lot of searching, and everyone in the hospital is kind.There were a lot of reviews that local anesthesia hurt more than I thought, so I got scared and entered the operating room, but it's similar to Jusarang's pain, so you don't have to worryI slept in the middle I expected the surgery reservation to be 3500 mo, but I thought I needed more, so I would like to thank you for adding 3700 mo without saying anything!!It's already been a day, but I'm looking forward to a year laterThank you to everyone at the hospital, including the director, for your hard work and please continue to take good care of us!

    조회수 217
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    헤어로의원 대구점
    HAIRO HAIR TRANSPLANT CENTER Daegu

    be worried about getting medicine for one's M-shaped forehead It's already been 9 months since we decided to have surgery When I post the first 2 weeks of reviews, I'm proud of it I had a lot of worries about the dark ages to come It's past the dark age and my hair is very natural and denseWhen I went to see him, he said it came out wellI followed how you took care of shampoo, so the dark days went wellOf course, a lot of people say we have to wait until a yearI feel like I'm already done with my hairWhen I planted it for the first time, I wanted it to grow out like this I'm happy with the design and hair, so it makes me laugh every time I look in the mirrorYou said you'd do a retouch for the parts that you feel sad about after a yearI'm still very satisfied, and I'm going to continue to manage it meticulously until a year.

    조회수 196
    댓글 1
    포토후기 이미지
    헤어로의원 동탄점
    HAIRO HAIR TRANSPLANT CENTER Dongtan

    Since I was young, my wide forehead has always been a big complex. I didn't have hair loss, but my forehead was wide, so I decided to transplant hair after thinking about it because there were many restrictions on my hairstyle.I didn't recommend that you plant a lot unconditionally, but suggested only 2,200 cap, which is an essential amount for my face shape and proportion, so my trust was confirmed.From counseling to the day of the surgery, both the director and the nurses responded very kindly, and they were very careful not to be nervous, so I was able to operate comfortably. 

    조회수 204
    댓글 1
    포토후기 이미지
    모디헤어플란트의원
    Modi hariplant

    I'm not the type to leave a review, but I'm writing it down because I'm worried about hair loss as I get older I didn't have a lot of hair 40I think the top of my head started to look empty in the late 1990s. I didn't have a lot of hair since I was young, so I thought I would have really little hair when I get older, but that became a reality, so honestly, I was a little surprisedEspecially under bright lights, it looks empty for no reason, and when you get on the escalator on your way to take the subway, the person behind you looks nervous.. \nAnd I've been trying to take it steadily I was taking pinasteride There was a time when I changed it to Dutasteride, but in my case, the shading came out pretty bad in the beginning, so I was very nervous At some point, the amount of hair that fell out when I washed my hair increased and the top of my head looked empty, so I came back to the pinasteride\nThen an acquaintance told me to go to the hospital and get treatment, so I went to consult him, but he checked my condition carefully and explained the direction of treatment \n At first, I didn't understand well, so I kept spacing out, but the manager explained the treatment well, and the director talked realistically about the current hair condition and what I can expect from now onJeon It's in the current state\nSo I started both PDRN injection and stem cell therapy, and in the beginning, I visited the hospital about twice a week I didn't feel much change in the first few months I think that's why I thought I lost money. \n But after about five or six months, I started to feel different when I was drying my hair \nIn the past, if the upper part of the head felt drooping and splitting, the volume gradually increased and the empty part decreased.\n So just in case, when I compared it to the previous picture, the parting line was definitely different Of course, I didn't go back to my hair when I was in my 20s and 30s, but I think it's a satisfactory change considering my age and condition. At first, I wondered if the treatment would really work, but after experiencing it firsthand, I can see why there are people who are constantly receiving care Hair loss is not a problem that can be solved in a short period of time, so I think it's important to manage it consistently without worrying about it I'm going to do my best and consistently\nI'm about a year and four months from the start of treatment and I'm quite satisfied with the progress so far I'm thinking of maintaining my current condition and getting regular care so that I can get a little better

    조회수 235
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    알파모의원
    an alpha-mocking circle

    I had M-shaped hair loss even before I got married, but I didn't pay much attention. I often wore hats while working night shifts, and I was always used to covering my hair loss by wearing hats when I was working out tennis.Then, I saw an acquaintance around me Hair Transplant and gained confidence, and thanks to my wife's recognition of the Alpha Mo clinic, I received counseling. At first, I was only going to receive counseling, but I gained faith because the director and the head of the department meticulously explained the current status, progress, and expected effects.It's been 90 days since the surgery. Most of the transplant hair is missing because it is a dark period commonly referred to after Hair Transplant, and even if you look at the picture, you can still see an empty part. At first, I was worried if it went well, but I was relieved that the head of the department recently checked the progress over the phone and informed me that my hair would start to grow in earnest around 6 months.There is not much noticeable change yet, but the hospital is constantly managing and guiding us, so we are waiting with confidence. I'm going to visit in the 9th month and get a progress diagnosis, so I'm looking forward to how naturally the hairline will be filled in the future.

    조회수 302
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    다나성형외과
    Dana Plastic Surgery

    As for the current status and satisfaction in the 6th month, it seems that 60-70% of the final target has come up. When it first came out, it was as thin as fluffy, but now it has become quite thick to the point where it is similar to existing hair. In the past, I used to fear windy days because of cracks in my bangs or empty areas, but now I'm confident enough to make it voluminous and style it with wax even if I dry it lightly. The inkiness of the scalp and other people's flesh that I felt at the beginning of the operation are now completely back, and the scarring of the collection site or the redness of the transplant site is barely noticeable now.To give a general review, the satisfaction level is currently at its best, to the extent that it is regrettable why it was not done even a day earlier. 

    조회수 255
    댓글 1
    포토후기 이미지
    모앤블레스모발이식
    Mo&Bless Hair Clinic

    I was struggling with emza hair loss and got help from my parents so I had a Hair Transplant at Mo & Bless!In the beginning, I had a lot of doubts about when it would grow and the result would be goodI'm glad the results were so good after trusting and following the director of Mo & Bless!!!I was worried because there was too much difference in parameters when I was in counseling, but I set the standard and tried it in an appropriate place, so I think I succeededHair Transplant There are a lot of people who do the 1st and 2nd round, but I think I succeeded at first.I think it's a good choice I'd love to make at Mo & Bless, even if something happens again as I get older in the future!

    조회수 242
    댓글 0
    포토후기 이미지
    모다올의원
    Modaol Hair Transplant

    My forehead is wide since I was young, so I finally solved the problem of planting my hair laterI went around three hospitals and thought about it before I decided The cost was up to 1 million won, but the decision was made after the hospital surgery or the doctorI decided to take into consideration the confidence you're talking aboutThe parameters were transplanted around 3,200 hairs, and the cost was around 7 million won I was thinking about incision and non-excision, but the prognosis of surgery is similar and it seems to be different depending on the individual, so I asked for a non-excision so that I wouldn't leave a scarThere were a lot of reviews about Yang Yoo-gun at the DAEDAMO, so I got surgery from him. He's confident and I'm very nervous, so I was worried about this kind of surgery.I got the surgery well because you were so good at it.I was worried that my blood was red on the first day, but now, on the 5th day, I've been shampooing once a day, and it's all gone and I've turned black to sit on the scabI'll have to wait to see if it's okay, but so far, nothing's missing, and the blood hasn't gone away since the first dayI'm satisfied and waiting for my hair line and hair because it's dense I'll post more reviews later when I have time

    조회수 275
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    모재성모발이식센터
    Mo Jaesung Plastic Surgery & Hair Transplant Center

    It's already been 4 months since the Hair Transplant surgery.From the second month, fluff began to come up one by one from the transplant site, and it still continues to grow.The overall density has not yet risen as expected, but compared to immediately after surgery, the change is clearly felt.In particular, the hairline is gradually becoming outlined as new hair comes up.I'm also satisfied that the director checks the progress in person every three months at the hospital.I was relieved that you explained in detail about the current status and the progress ahead.It's still in the fourth month, so I think it's early to evaluate the full-fledged results.Expectations are growing as people around me are hearing that it seems to have changed little by little.We're going to wait and see how much density and thickness will improve by the next six months, nine months, and one year.I'll also leave the next progress and review honestly.

    조회수 245
    댓글 1
    포토후기 이미지
    모더함의원 모발이식센터
    Moderhamm Clinic — Hair Transplant Center

    "Modern hospital reviews the day after male non-intersected Hair Transplant surgery" ✔ Surgical type (Hair Transplant or hairline correction): Hair Transplant ✔ Name of hospital (no initials): Apgujeong Mo + Theham Clinic ✔ Hair loss type: Frontline down + Front density + Em-self-oriented (ex. Emza hair loss, crown hair loss, frontal hair loss, wide forehead, female hair loss, hairline correction, not hair loss) ✔ Expiration period: the day after surgery ✔ Number of wool (clothes): 3196 wool ✔ Cost of Hair Transplant: KRW 8 million ✔ Collection method: Non-cut micro-hydric cut (ex. Cut hair transplant, non-cut hair transplant, partial cut, no cut) ✔ Transplantation method and doctor/nurse transplantation: Planting machine & doctor transplantation ✔ Progress and photos:

    조회수 168
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    헤어로의원 전주점
    HAIRO HAIR TRANSPLANT CENTER Jeonju

    I write a review after two months of reporting a year.In conclusion, if you compare the picture you received after 9 months It's definitely thicker, but I think I've gained more strength.After getting Hair Transplant, I changed my diet and shampoo for about a year. I took care of smoking/drinking by reducing the number of times, but I got compensation I'm feeling the best because I'm in a good mood.I'm happy that I was able to achieve the design I wanted.My co-workers saw my hair and got interested in it I had a lot of colleagues, so I recommended some of them He's getting treatment and getting results. He always says he's thankful when he encounters me He's buying coffee I'm also taking care of my scalp I'm thinking about getting it, but I think it's better to take care of hair loss in advance.It's too fast when you suddenly have an "m" shape and start to fall out.Then I'll graduate from hair loss^^

    조회수 210
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    포토후기 이미지
    인천 맘모스헤어라인의원
    Incheon Mammoth Hair Restoration Center

    The laryngeal pain that I was worried about was only slightly uncomfortable on the night of the surgery. From the next day, I didn't feel any pain at all, so there was no problem with my daily life.Rather, the discomfort of not sleeping comfortably was greater than the pain.Finally, the birth period is over, so from today, normal shampoo will be used. I visited the hospital, met the director, and checked the progress, and I can see that the transplant hairs are very tightly embedded as the dead skin cells fall. The line is also the natural hairline I wanted, and I think it came out well without being excessive. The part where the back of the head is collected is already grown, so when the back of the head falls down, it is not noticeable and there is no pain at all.Thank you to the nurses who kept checking so that the operating room atmosphere was not heavy and the managers who cared for the postoperative care service. The dark age will come now, but I'll take good care of my mental health. If you have any questions, please leave a comment and I'll answer as far as I know. 

    조회수 331
    댓글 1
    포토후기 이미지
    모아트의원
    moart clinic

    Hello.It's a review of the nine months that you use for about 10 months.I'm very, very satisfied.There are also regrets that I should say more when I do it.Thank you, Gangnam farmer.

    조회수 339
    댓글 3
    포토후기 이미지
    용닥터의원
    Yong Doctor Hair Transplant Surgery

    I received my first Hair Transplant in 2011 and it's already my third Hair Transplant!I don't like the first and the second. I think it's the last oneI really worked hard to find a hospitalThen, Dr. YONG came up on the YouTube algorithm and I happened to watch itWatching your YouTube videos, I felt like you were serious about hair loss and Hair Transplant.I made a consultation appointment with my gut feeling that this could be the last Hair Transplant hospital.It's my third surgery, so I wrote down a lot of questionsI asked them one by one, but they answered everything calmly without showing any signs of annoyanceI've got a lot of trustAll I wanted was an M-shaped reinforcement of my bangs and a small transplant of the top of my headThe hair stylist made the front line really neatThe top of the head was transplanted to the extent that I wanted!I'm very satisfied with the density that I was disappointed with after the second surgeryEven the top of the head, which looked slightly empty, feels like it's filled up properly after surgery, so it's goodDirector Kim Yongbin, thank you for ending the Hair Transplant's journey in a great way!

    조회수 542
    댓글 2
    포토후기 이미지
    포헤어 비절개모발이식센터
    FORHAIR Hair Transplant Korea

    It's already been four months since I received a non-cutaneous Hair Transplant at Apgujeong FORHAIR Hair Transplant Korea.After the most frustrating period due to the dark age, I think I have entered a section where I can see changes little by little, so I leave the progress.Before the surgery, the M-shaped part became deeper, so I felt like I could see an empty space even if I put my bangs down, but now every time I look in the mirror I think I'm getting a definitely different impression from before. Of course, it's not yet complete, but it's time for transplants to start showing up I think the expression is just right.In the 2nd or 3rd month, I honestly was a little concerned because there was more loss than I thought. Especially during the dark ages, there was a big difference between left and rightThe left side is missing more than the right side. So when I took a picture, it looked empty on one side There were times when I wondered if it was growing well.However, the situation has changed a little as we entered the fourth month. The hair started to come back up from where it fell off Now, the right side has grown faster, and the length difference is visible. At first, I thought this was okay, too When I went to see the progress, I asked you, and each hair has a different growth cycle, so there are cases where one side comes up first or the length is different I heard it's more common than you think. I've been told that it will be naturally matched over time, so I'm not paying much attention now.Personally, the most I feel this month is the change in the atmosphere in the front line. In the past, when I put my hair back If you saw the M-shaped part first, now the fine hairs come up and the line is much softer. The density is still high However, compared to preoperative photos, the empty space itself seems to have decreased a lot.And it's working well even when you check the progress It doesn't end like that. It's about the current state and the process of change It was nice to explain about it. I was worried about the different growth rates in the dark ages It reduces unnecessary stress. After receiving follow-up care, I thought I understood a little why many people were looking for forehair.It's still in its fourth month, so it seems that the most frustrating section of the dark age has definitely passed. I think it's a process where new hair is getting thicker and thicker, and it's a time when changes occurI'm trying to manage it hard and wait and see how much more different it will be.

    조회수 391
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    포토후기 이미지
    압구정 맘모스헤어라인의원
    Mammoth Hair Restoration Center, Apgujeong

     I visited the hospital to see the last 10 monthsNow that I'm in my 10th month, my hair has grown a lot, so I think I'll be able to put it behind my ears soon. There's nothing to take care of because it's well-worn, so can I just leave it to you on time??? My grown hair is very natural and the part where I pulled it out is not obvious, so I don't know if I pulled it out even if I look closelyAnd I think it's a good thing that I got a hairline transplant without getting a hairline tattooI didn't need follow-up care because it came out well, but I was so happy that you took care of your scalp until the 10th month! They take care of the scalp very well, and the director and the staff are all kind.And the location is only 10 minutes away from the express bus terminal and it's just a minute away from the subway station, so it's convenient to go from other regions, and when other people ask you to recommend hairline, do you recommend Mammoth Hair Restoration Center?????? Be prosperous!!

    조회수 382
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    포토후기 이미지
    부산 리즈모
    Rizmo Clinic - Busan Branch

     It's already been 10 months since I had Hair Transplant surgery. At the time of the operation, I performed it in a non-cut and non-cut manner, so it was really comfortable and good when I went back to my daily life or work because it was almost invisible right after the operation. Now, 10 months later, the hairline is very natural like my original hair, so I'm very satisfied every time I look in the mirror. If you have any questions about the process or changes you have managed throughout the dark ages, please feel free to leave a comment. I hope we can share a lot of good information with each other. Thank you.

    조회수 359
    댓글 3
    포토후기 이미지
    노블라인의원
    The Nobleline Center for Alopecia Care

     It's been four months, and the speed and area of the head look similar to others and sometimes it looks better. Since it's my daily life, I'm just living without much thought, but people around me are more surprised than I am. But what's so interesting is that you've taken a really large amount of hair from the back of your head, and if you don't tell it, it's so obvious that no one knows it. Every time I see this part, I really admire the doctor's medicine. I didn't plant a lot on the top of the head in the first place, so I didn't know, but since the hair comes up on the front, it doesn't look relatively empty, but it's still 4 months old, so I'll wait a little longer. There's an irony that the front is filled and the back looks empty. If you do a mass transplant, it would be better to know this part in advance. I'm very satisfied so far, and I think I'll be even more satisfied in the future if the hair is more full. 

    조회수 554
    댓글 1
    포토후기 이미지
    모바른의원
    MOBARUN HAIR SURGERY

    I'm a man who had a hair transplant a year ago at Morbarn Clinic.My forehead is naturally wide, and I think my hair is going onWhile visiting the hospital, I visited Han Sang-bo, the director I met on TV and various media, and received an Hair Transplant. The counselors and the nurses were very kind and they checked very carefully. It's just been a year now, and I'm satisfied with the results and the birth rate is really good even though my hair is malignant. Thank you!

    조회수 553
    댓글 2
    포토후기 이미지
    뉴헤어모발성형외과의원
    NEWHAiR

     <Before surgery> <After surgery>This is the review of the 7th day after Hair Transplant surgery.I was worried that the upper hair loss was getting worse, so I decided on Hair Transplant. On the day of the surgery, I had a little pain and swelling on my forehead, but it wasn't as bad as I thought, and I followed the precautions I was guided by taking the prescribed medicine.For two to three days after surgery, I was careful not to touch the transplant site, and I was also careful not to press my head when sleeping. I'm currently on day 7 and most of the swelling has subsided and there's almost no pain. There are still scabs left, but we are carefully managing them because it is an important time for birth.It's still too early to judge the results, but so far, I'm recovering without much inconvenience and I'm satisfied.I'll watch the progress and leave a review in my spare time.

    조회수 478
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    포토후기 이미지
    모우림의원
    Mowoolim Clinic

    Apgujeong reverse hair transplant is a review of Mo Woo-rim clinic before the operation He had a wide forehead and an M shapeI got counseling at the Mo Woo-rim clinic after my acquaintance's recommendation, and I got counseling from Han Ji-youngHe was kind in counseling and recommended by Director Lee Seung-ah, so I set the parameter to 1,700mo after consultation with the directorI'm scared and nervous, but I liked that both the staff and the director were kind I didn't feel any pain because of anesthesia on the day of surgery After that, the pain was okay because I took the medicine, but I had surgery with an incision, so it was quite painful because the incision came into contact with it when I slept, right????I thought I should plant more because human greed is endless, but first of all, I hope the transplant hair is well-established, so I hope it's maintained well

    조회수 440
    댓글 2
    포토후기 이미지
    모모의원 부산점
    Momo Clinic

    Hello, I'm leaving a final review of a year after transplanting.I've left a few reviews after surgery before, but it's annoyingI think it'd be better to share the final review after I forget about it because my hair grows well I'll leave it.I've had hair loss for a long time, and I've had scalp injections 10 years ago, and in between, I've had avodat It's not easy to eat after eating some, so I stopped and left it unattended, but decided to Hair Transplant last year.The hair loss got worse when I left it unattended.I live in Ulsan, but when I looked for it, there was no Ulsan hair loss hospital, so I looked into Busan. Looking at the reviews of the DAEDAMO, there were many hospitals in Hair Transplant, so I was consulted to Busan, and the consultation with Director Ko Sang-jin was the best, and the hospital was big, so I got a transplant here.I got it as a non-cutter, and I took a day off from transplant and worked, and it was good that my recovery was really fast.In the beginning, I had itchy things for a few days, so I was thinking about sleeping with plastic gloves on, but not for a long time. I think it was for a couple of daysThe dark ages came for about two months, and by the time I was six months old, my hair grew a lot.It's been a year now, and I heard that it usually takes about a year to complete your hair, but by my standards, it was almost completed after about 10 months.I'm going to upload a comparison shot between the picture I posted last time and the picture of my first year.Grow up, everyone.

    조회수 524
    댓글 6
    포토후기 이미지
    모우다의원
    MOUDA CLINIC

    I chose it because I believed in the beauty and meticulousness of the female director of the MOUDA CLINIC.The consultation was also conducted only with the director, and he told me his questions clearly, so I decided right away.It's been three weeksExcept for not being able to cool down shampoo, I've been doing well so that I don't feel too sick, itchy, or uncomfortable.I'm relieved to hear that it went well.In particular, I wanted to fill only the empty spots naturally, but I like it even more because it transplanted so that I can save my baby hair.In the second week, I also sprayed medicine on the occipital region and received laser treatment.I'm really looking forward to the future.My scalp is still a little red, but it'll get better over time.I'm not really worried. 

    조회수 411
    댓글 2
    포토후기 이미지
    부산 맘모스헤어라인의원
    Mammoth Hair Restoration Center Busan

    It's already been nine months since I started Hair Transplant. I think time has gone by really quickly.For postoperative management, I have been taking and managing the medicine steadily as the hospital guided me. I was worried at the beginning, but as time went by, I saw a change, and now I'm quite satisfied.As expected, I think it was a good choice to choose Mammoth Hair Restoration Center. Whenever I come to see the progress, I am always grateful for checking the condition meticulously and responding kindly.Although it is still satisfactory, I am looking forward to the future as the normal Hair Transplant can continue to change from a year to a year and a half.I hope my experience will be a little helpful to those who are considering surgery. Thank you to the Mammoth Hair Restoration Center medical staff for their kind management and care. 

    조회수 467
    댓글 0
    포토후기 이미지
    움찬의원
    WOOMCHAN Hair Transplant Clinic

    I visited after thinking about the Hair Transplant, and I was relieved that you were very kind to proceed with the consultation. The director meticulously conducted the entire process from counseling to surgery, and explained in detail the questions in the middle. You took care of it carefully so that you could receive it comfortably on the day of surgery, and the results are satisfactory. I would like to recommend it to those who are concerned about Hair Transplant. 

    조회수 425
    댓글 1
    포토후기 이미지
    연세모벨르의원 인천점
    Yonsei Mobelle Clinic - Incheon Branch

    I transplanted 3,000 hairs with a non-excisional Hair Transplant.It's the 2nd week so farI searched a lot about this place and chose a hospitalDirector, the consulting teacher, in detail to make it easier to understand Thank you for letting me knowI was thinking about getting my forehead done, but I was going to get surgery on my stomach I heard it's better to get a forehead treatment after a transplant Transplantation first  I did. I'm very interested in doing facial procedures. ^^I did partial anesthesia. The surgery was relatively easy As the hospital told me, I took good care of it after the surgeryI was worried that it would work because my hair was thin and thinIt's been 2 weeks, so I don't know yet, but I didn't have hair in the beginning I think the director did a good job These hairsI'm looking forward to it when I think it's growing fast.in the next four months  I'll upload another picture

    조회수 489
    댓글 1
    포토후기 이미지
    모든모의원
    Modeunmo Clinic

    Hello, I got a Hair Transplant for an incision about 10 years ago.I feel like I'm losing density againWe had a re-movement ceremony ^^I was much more satisfied than before because I didn't have any scarsI've been through the dark ages before, but I still can't get used to itI'll think it's just the beginning, and I'll work harder to show you good results

    조회수 592
    댓글 4
    포토후기 이미지
    인천 마이모 모발이식의원
    MYMO HAIR TRANSPLANT CENTER Incheon

     After removing the scab.There is still a redness in the transplanted part.And the back of the head collected from the hair is also very slightly painful and sometimes itchy. It was said to be a normal thing in the recovery phase.From now on, the transplanted hair will fall out for about a month, so I'll take good care of it.

    조회수 672
    댓글 2
    포토후기 이미지
    연세모벨르의원 대구점
    Yonsei Mobelle Clinic - Daegu Branch

    Actually, I had a Hair Transplant by incision about 10 years ago. I was satisfied at the time, but as time passed, hair loss progressed little by little, In particular, the density of the part in the middle looked very empty. It bothers me every time I look in the mirror, so I ended up looking for reoperation.There were only two things I saw importantly while looking for a reoperation hospital.The first is a place with a lot of experience in non-cutaneous Hair Transplant. To be honest, I remember having a hard time during the first incision This time, I thought I should definitely make it non-cut.The second is where the doctor conducts the surgery himself from the beginning to the end. I went to counseling, and the actual transplant was done by a doctor There are places where other people host. It took me a while. Aside from the cost, it's a reoperation, so from beginning to end I wanted a place where the director would do it himself.I got counseling from various places and got counseling from Yonsei Mobel You explained it in great detail. Especially in the case of reoperation like me, the part that was transplanted before became hard They said that if you use only a hair implanter, you can get a popping phenomenon where your hair sticks out.That's why I was recommended to use the slit and the hair implanter together to increase the birth rate. I'm not just sticking to one method It was reliable that we proceeded according to the current scalp condition.Most of all, the slit process was also carried out by the doctor himself. These seem to have been the biggest reasons for deciding on a hospital.It hasn't been a long time since the surgery, but the progress so far is satisfactory. The transplant area is cleaner than I thought, The actual surgery process was not much different from the explanation I heard during the consultation.Of course, we'll know the final result after a few more months I have an expectation that it will settle down well with the current feeling.

    조회수 651
    댓글 3
    포토후기 이미지
    JP성형외과
    JP Hair Transplant Clinic

    I planned a Hair Transplant but it didn't work out.I recently went back to consultation and had Hair Transplant two weeks ago.But this time, we got an eyebrow transplant consultation and we did the transplant togetherAs shown in the picture, the hair implanted in the transplant area is well positionedMost of the redness and scabs are goneAs you can see from the pictures before the surgeryIt didn't grow at all in the empty areaSo I got a small 170-mo transplantI think it looks much more natural, so I like it. What do you think…My forehead was a bit swollen in the beginning, but after a week, I recovered naturallyI'm comfortable with my daily lifeThe occipital collection area doesn't show as much as you think because your hair growsIt's definitely a good feeling to cut the nasal sectionIf it's dark, your hair will fall outI'm a little worried, but I hope you sleep like this

    조회수 890
    댓글 8
    포토후기 이미지
    광주 압구정모비앙의원
    apgujeong mobien

    Mobien came to see people around him after the procedure.The person who got the procedure from Choi Hyun-yong looked so good that I also got a transplant from Choi Hyun-yong. Having a hard time with sleep anesthesia, I was very nervous about having to do it twice, but the nurse and director next to me kept talking to me and making me comfortable, so I was able to relax and get a transplant comfortably. The director set the transplant line so naturally that it looks like my original line, so I'm so happy that I don't care about my daily life. I'm looking forward to the future because I've heard that the hairline looks much better because it's alive.  

    조회수 689
    댓글 2
    포토후기 이미지
    모모의원 수원점
    MOMO's Suwon branch

    Hello~ As expected, transplantation is the answer. I'm also experiencing the results over time after transplanting and I'm directly experiencing the words. I've been getting counseling because I wanted to get a Hair Transplant for a while, but I delayed it because I couldn't find time and hesitated, and I finally got a transplant last year, and the result is amazing.The deep m-shape disappeared. I think I'm so free to do my hairstyle I wanted to grow out my hair again. Sports hair? I cut my hair close to a half-length hair Overall, it's growing again. When my hair grows completely, I'm going to try something I couldn't do before because of the m shapeWhen I was looking for surgery, I was consulted at a hospital in Seoul, and when I saw the establishment of Momo Suwon branch, I found out that I had surgery, and I highly recommend Director Moon Hyo-seop.I looked up the reviews of the past and asked the hospital, but the director had more than 20 years of Hair Transplant experience and he was a complete veteran with more than 5,000 surgeries. I think the most important thing in Hair Transplant is the doctor's career and skill.I had a common m shape, but I heard that the director was a person who did a lot of difficult surgeries, but the class definitely feels different.Suwon people who are looking at my reviews, don't go to Seoul and the Suwon branch in MOMO HAIR TRANSPLANT that I operated on is good.The director's career is clear, and I believe MOMO HAIR TRANSPLANT is a famous hospital in Seoul.I'm 10 months old, but I think the results are all out. I don't know if I'll leave a review next timeEveryone, finish the "m" shape and take over [Laughing out loud]

    조회수 906
    댓글 3
    포토후기 이미지
    헤어로의원 부산점
    HAIRO HAIR TRANSPLANT CENTER Busan

    as a result of poor hair loss managementMy hair that only fell out on my forehead... It's more than my hair getting widerIt's starting to go up to the top of my headI think I'll have to wear a wig if it gets worseI went to some consultations in Seomyeon, where there are a lot of Hair Loss Hospital.I heard that all the places I went to have a lot of parameters to plantIf you have to plant a lot, I think someone with a long career will do wellI got a Hair Transplant from HAIRO HAIR TRANSPLANT CENTER in Busan.I shaved my headThe surgery took a long time, but they kept checking the inconvenienceI remember having a comfortable surgeryI checked the progress, and so far, I've heard that he's in good conditionWhen I look at the line and hair density in the mirror, it looks okayI feel like I got it from a skilled directorI received prescriptions and explanations on how to take care of themI need to take care of it as I've been taught

    조회수 1,117
    댓글 7
    포토후기 이미지
    글로웰의원
    GLOWELL

    I'm 6 months old after receiving a transplant with 3,000 non-cutaneous hairs. If you look at the picture that I just finished the design before the surgery, you'll know The forehead line was also messy and unbalanced, so I didn't want to see it. So during the consultation, I asked the hair stylist to correct my hair line I said I wanted to keep my bangs cool You made the line look natural according to my face proportion During the dark ages, my hair fell out quite a bit, so I had a hard time It grew amazingly from the next month It's good enough to look at it now. It's only been 6 months, so my hair isn't 100% grown I heard that it needs to be more dense Honestly, I'm satisfied with how it is right now It was done through a nasal incision, and the place where the back of the head was collected was recovered quickly I didn't have much inconvenience in my daily life. Above all, as the hairline becomes neat, the impression itself seems to have improved. I'll come back with a review later when it's been a year and it's fuller! 

    조회수 982
    댓글 4
    포토후기 이미지
    모모성형외과의원
    MOMO HAIR TRANSPLANT

    Hello, I'm going to write the last review after the transplantI left a few reviews after getting the transplant, but I feel strange because the results are completely out and I leave themI saw the results of a senior who recommended Hair Transplant to me, and I saw a lot of other people's reviews through DAEDAMO.I feel new after getting such good results.I lived as an M and started taking medicine to protect my remaining hair, and with the company's senior recommendation and bragging I was introduced to the hospital and had surgery last year while taking summer vacationThere are many Hair Transplant hospitals in Gangnam, but Momo Plastic Surgery is the hospital that has been verified by seniors.I didn't go anywhere else, and I got counseling right here and even had surgery.There is a lot of information in the DAEDAMO, so everyone is quick, but let me introduce a little bit of the process I went through.First of all, it was an M-shape, and I got a 2,500-mo estimate, and I had surgery, but both incisions and non-incisions were possible After thinking about it, I chose an incision to save a little money, and because it was an incision, there was no shaved head on the back, so it was better in this area because it didn't even show the back of the hair after surgeryAfter 2 weeks, I started removing the thread and getting my fingerprint shamp done, but when I washed my hair for 2 weeks, I felt a little uncomfortable and bothered a lot.The dark age is an essential process that most people go through when they Hair Transplant, but when it comes down, it's a time where I feel bittersweet and worried.It was a time when I waited, watching all the hair that had been transplanted and planted so heavily disappeared at some point and became a mountain of Mindung again.The dark age was maintained for about three months.And around the halfway point, the heads began to grow again in the empty area, and from then on, the heads came up in abundance like running without hesitation, which is really touching.I personally felt the surprise of medical technology.When I think about it when I was young, I remember people living bald or wearing lame wigs, but now I'm turning my hair back, which was gone due to Hair Transplant.I got the hair transplant cost well, so I had surgery, and the result was very satisfactory. Thank you for the MOMO HAIR TRANSPLANT in many ways.I hope you all get good results with your Hair Transplant.

    조회수 1,190
    댓글 5
    포토후기 이미지
    모모의원 대구점
    Momo Clinic

    Hello, I'm keeping a record of the transplant.Actually, I didn't think I would be the Hair Transplant right away.I've been in the M shape for a while, and my wife has been telling me that the top of my head seems to be losing some weightI didn't mean to get my Hair Transplant straight away, but maybe it's because I saw it on my phone regarding hair loss and Hair Transplant...The algorithm brought me content related to Hair Transplant.As I was forced to watch it, I was curious and wanted to find out how much it cost, so I took some counseling as an experience, and some places were really expensive and told to operate right away, and consultations varied slightly from hospital to hospitalSome places are good to have surgery, but you said it was up to me to make the decision, and it was good because you explained the overall picture before and after the surgery and the expected hair loss progress. When I listened to the explanation and looked at the pictures of other people's surgeries, I didn't want to have surgery right away, but I couldn't think of Hair Transplant in my head.I'm not the type of person who decides something so quickly in my life, but I keep thinking about it and recommending my wife to have surgery, so I decided to get surgery by Kang Dong-woo, who had good counseling and cost well, and I completed 3,500-mo surgery. 3,000 M-shaped and 500-shaped transplants were received on the top of the head.When I first saw the contents related to Director Kang Dong-woo, I felt something gentle and likeable, but I thought positively when I received actual counseling. Above all, as mentioned above, I was impressed by your explanation from my point of view and comprehensive counseling such as what will happen in the future.I operated on the M shape and the top of my head at once, and I was prescribed medicine and started taking it.In my standards, I finished the surgery unexpectedly, but I'm looking forward to a good result because I had the surgery.I wonder what other people think.

    조회수 1,164
    댓글 6
    포토후기 이미지
    모제림성형외과의원
    MOJELIM Hair Transplant

    It's already been a year since I started Hair Transplant.I can't think of a frog tadpole.. It's become so natural now that I don't even know if I've had hair loss.. I'm not sureThis was before the surgery  Looking at it like this, it was really bad..It was a time when I was covering up the M shape because I was embarrassed just by blowing the wind..And on the first day of surgery It was really dense lolI thought I wanted this to be my head, and I remember being really happy.And it's been 6 months I was actually a little worried at this time.Anyway, I knew it was going to get denser, but it was a time when it was full.And this is my last year's hair lol I slept really well, right?I'm really confident nowI don't care whether it's windy or notThese days, I'm so happy to find my bangs that were abundant in my 20s.It's all thanks to the director Choi Dongwook who did a great job Thank you!

    조회수 1,470
    댓글 4
    포토후기 이미지
    바람부는날에도 성형외과의원
    Banal Plastic Surgery Clinic

    My hair is thin and thin, so I visited at first as a Hair Transplant consultation, but after the consultation, I heard that forehead reduction is more suitable for my condition, so I proceeded. Director Park Soo-ho explained the operation method, recovery process, and genuine endotin used in detail, so I trusted him. There was a private recovery space before and after the surgery, so I was able to relax a lot with my guardian and the overall movement and care were comfortable. It's not that I don't have scars at all, but it's a line just below my hair, so it's not as noticeable as I thought, and people around me don't know at all. I've always been stressed out with a wide forehead since I was young, but now I feel confident tying my hair, and I feel like I've solved my lifelong worries, so I'm so satisfied :)

    조회수 1,376
    댓글 9
    포토후기 이미지
    대전 리즈모 모발이식 센터
    Rizmo Clinic - Daejeon Branch

     Hair loss has progressed slowly since about five years ago, and at first, it didn't matter, but at some point, it bothers me every time I look in the mirror. I tried medicine and managed it, but there was no noticeable change, so I ended up thinking about Hair Transplant. While looking up various hair loss communities, I was looking for information toward Daejeon Hair Transplant and naturally learned about Daejeon Rizmo Clinic.It could have been cumbersome to find out the hospital from Nonsan where I live to Daejeon, but looking at the reviews, the trust in the Rizmo Clinic in Daejeon gradually built up. It wasn't just an advertising feeling, but there were a lot of actual experiences, and there were a lot of stories that the results were natural, so I was inclined.In the end, I decided to get counseling in person, and I decided that the results were more important than the trouble of moving from Nonsan to Daejeon.When I got counseling, I understood why many people choose Daejeon Rizmo Clinic.The consultation process was very meticulous, and I trusted you because you carefully explained the design and implantation direction suitable for the current condition.I proceeded with a total of 4554 hats in a non-cut manner, and it was impressive to point out exactly what was needed without feeling overly recommended.Even among hospitals in Hair Transplant, Daejeon, I felt that such detailed counseling was not common.On the day of the surgery, it was more nerve-wracking than expected, but the process itself was relatively comfortable.It was a non-cut method, so there was little burden of recovery, and I was relieved that you checked the condition in between. Above all, I felt the proficiency of the medical staff, and I felt that the speed and concentration of progress were quite high.I was glad that I chose Daejeon Rizmo Clinic at this time.It hasn't been long yet, but overall satisfaction is high so far. We have to wait and see the progress in the future, but I feel like I got the first button right. If you've been worried about moving to Daejeon, I think you can consider the results first like me. If you are thinking about Hair Transplant in Daejeon, I think Rizmo Clinic in Daejeon is a good option to consider.

    조회수 2,276
    댓글 7
    포토후기 이미지
    모먼트의원
    Moment Clinic

    It's already been 6 months since the surgery. There was a holiday holiday, and I was a little busy, so I couldn't go to the hospital in the 5th month, and I went to see it for 6 months not too long ago. When I had my first surgery, I was very much waiting for my hair to come up, but now I'm amazed to see how it changes little by little every time I look in the mirror.I saw little hairs coming up from the third to fourth months, and now that I'm in the fifth month, I felt like the number of hairs coming up has increased significantly. In the past, the scalp looked more prominent when the top of the head or the front was reflected in the light, but these days, it looks much less empty than before even in the same lighting. It's almost six months old now, but it's definitely different. The biggest difference is hair thickness. After six months, I can see a lot of children getting thicker like existing hair. The line is being held naturally as it was designed for the first time, and now even when I look in the mirror, I rarely feel as stressed as I used to. Of course, I don't think it's complete yet. The density is likely to rise further in the future, and there seems to be room for a little more filling in the middle. The director said that this is the middle process, but I'm looking forward to it because it will become thicker and denser in about six more months. The progress so far is satisfactory enough, and I'm waiting to see how much better it will get in the future.In the next review, I'll leave it with a richer look.

    조회수 3,508
    댓글 8
    포토후기 이미지
    모션모발이식의원
    Motion Hair Clinic

    In my early 20s, I decided to have a hair transplant to correct M-shaped hair loss and lower forehead height, and when I first visited the hospital, both doctors and nurses gave me a reliable explanation, so I started the surgery right away. After that, the scab was removed in the second week, and unlike other hospitals, I was informed that I could start drinking and smoking, and from the first month, the transplant hair began to fall out, and now I have almost no hair.

    조회수 7,964
    댓글 7
    포토후기 이미지
    모아만의원
    MOAMAN CLINIC

    One month after surgery, a brief review is added. Two weeks after pulling out the thread, I visited the hospital for dead skin care. It's a 200,000 won service, so I just spray the medicine, wash my hair, and soak it in infrared for 10 minutes. (If I pay for it, I'll get it approved...) I took a few pictures and got prescribed hair loss medicine and came down.. The next visit is in nine months. After about a month, the dark ages seem to begin. After the fingerprint shampoo, the existing hair and transplant hair fall out a lot. Slight pain in the incision/transplant area when shampooing.

    조회수 11,740
    댓글 11

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