Pinasteride: Information on Finasteride-based generic drugs worldwide, including Propecia, Pinfecia, Prosca, and Pinca. 

Dutasteride: adot, generic adot information/ minoxidyl tablet: minoxidyl to eat / spironolactone: aldactone, spirodactone

5% Minoxidil : Information on the minoxidil family such as Rogain, Regain, Zandrox, Minoxil, Scalpmed, etc

Other medicines: cimetidine, roacutane, steva A (tretinoin), diane, drogen tablet, pantoga

[Finasteride] I guess Puka can treat acne.

  • 20years ago

  • 1,818
0
5 months and a half on P.C.A.P.C..My acne is gone after 1~2 months of eating..
I used to get one or two a week..a big pimple
I can't hear anything so far..
Of course, I've avoided fatty foods and meat..
But why does my head get worse..

Finasteride


As a 4-azo analog of testosterone, it selectively acts on sterid 5α-reductase, an enzyme that converts testosterone to DHT (5α-dihydrotestosterone), and inhibits it competitively. As a result, it significantly reduces the DHT concentration in the blood.

The inhibitory action against 5α-reductase appears dose-dependent.

There is no affinity for the Androgen receptor.



Clinical Uses


Treatment of symptoms of benign prostatic hyperplasia (BPH)

Efficacy under clinical study:

Treatment assistance after radical prostatectomy

Prevention of cancer progression in stage 1 prostate cancer

the treatment of male baldness, acne, and polymyelosis





Pharmacokinetics Treatment Effect Time: Within 3-6 months

Duration of action:

0.5 mg, after one oral dose: 65% inhibitory effect of blood DHT (5α-dihydrotestosterone) concentration lasts 5-7 days.

5 mg/day, after 6 months of treatment: blood concentration normalizes within 14 days of discontinuation of treatment.

Absorption:

It absorbs well.

The rate of absorption may be delayed by food, but there is no change in the in vivo utilization rate.

In vivo utilization rate: 63% on average

Distribution: Placenta Passes

Distribution volume: average 76 L

Protein binding: approximately 90%

Line:

Most of it is metabolized in the liver.

Unaltered bodies were mainly found within the circulatory system, and two active metabolites were homologous.

Half-life: 4.7-7.1 hours

Elderly people aged 70 or older: 8 hours (6-15 hours) on average

Maximum blood concentration time: 2-6 hours

When administering an empty stomach: 1.9 hours

When administered after meals: 4.2 hours

Loss: excreted through urine (average 39%) and feces (average 57%) as metabolites.



occasional side effects

Endocrine system and metabolism: decreased libido

Uroliferative system: Impotence, decreased ejaculation


a rare side effect

Endocrine system and metabolism: Breast tenderness and hypertrophy

Other: Over-reaction (swelling of lips, skin rash, etc.)
  • The contents of this post are based on the user's personal experience and public general information, and are not intended to advertise, promote, or encourage the use of certain medicines. Please consult a medical professional for the use of prescription drugs and treatment.

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