High green conditions

1. Adults (12 years old or older): Minoxidil is administered orally once a day at a first dose of 5 mg, and 10-40 mg is divided into 1-multiple doses per day as maintenance. It can be administered up to 100 mg per day.

2. Children (under 12 years old): 0.2 mg per kg of body weight is administered once a day at a first dose and can be increased by 50-100% until blood pressure is adjusted to optimum conditions. As a maintenance amount, 0.25mg-1.0mg per kg of body weight is administered per day. It can be administered up to 50 mg per day.

3. Frequency of administration: The magnitude of daily arterial blood pressure fluctuations during administration of this drug is proportional to the blood pressure reduction. If the decrease in coordination diastolic pressure is less than 30mmHg, it may be administered once a day, and if the coordination diastolic pressure is more than 30mmHg, it is divided and administered twice a day.

4. Dose change: The dose is carefully determined according to the patient's response, and when controlling the dose, a sufficient response to the dose must be at least three days, so it is a principle to keep at least three days apart. If more rapid hypertension treatment is required, the dose can be adjusted every 6 hours while carefully observing the patient.

5. co-administration
1) Diuretics: This drug has been co-administered with diuretics to patients who rely on renal function to maintain the balance of salt and moisture, and has been co-administered with the following diuretics.
① Hydrochlorothiazide (50 mg twice a day) or other dental diuretics (equivalent effective dose)
② Chloridone (50-100mg once a day)
③ Furosemide (40 mg twice a day)
If the weight is increased by more than about 1.8 kg due to excessive salt and water retention, the diuretic should be converted to furosemide, and if you are already receiving furosemide, increase the dose as necessary.
2) β-blocker or other sympathetic nerve blocker: When administering this drug, as propranolol, a β-blocker equivalent to 80-160 mg per day is divided. If the β-blocker is banned, methyldopa (250-750 mg twice a day) can be administered instead. Because methyldopa takes time to show its action, it is administered at least 24 hours before the administration of this drug. Sympathetic nerve blockers may not completely block the increase in heart rate due to this drug, but they can generally prevent tachycardia. Patients receiving β-blockers prior to initiation of this drug therapy typically exhibit bradycardia, but administration of this drug is estimated to increase their heart rate and become normal. The combination of this drug and β-blocker or other sympathetic nerve blockers cancels out each other's opposite effects on the heart, leaving little change in heart rate.

It increases or decreases appropriately according to age and symptoms.

1) Hypertension due to symptomatic or target organ damage
2) Hypertension that does not respond to the maximum dose of both diuretics and two types of hypotension (non-adaptive hypertension)