We have found a clue to the development of hair loss treatments using adipose stem cells.
Professor Sung Jong-hyuk's team at Yonsei University (pharmaceutical department) announced on the 9th that it has found that treating adipose stem cells with a "D-type platelet-derived growth factor" induces effective hair regeneration.
The research team confirmed that growth and proliferation more than doubled after treating adipose stem cells with a "D-type platelet-derived growth factor" that induces cell proliferation and differentiation. Furthermore, as a result of injecting fat stem cells cultured in this way into the mouse's subcutaneous area, it was found that growing hair was induced and the hair proliferated.
The D-type platelet-derived growth factor is expected to reduce the amount of adipose stem cells by helping them achieve the same hair growth promotion effect even when using a small amount of adipose stem cells.
This effect is because active oxygen produced by D-type platelet-derived growth factors stimulates stem cells. When D-type platelet-derived growth factors stimulate mitochondria, free oxygen is produced, which acts like a signal transporter to activate the signaling pathway related to cell growth and division, promoting the secretion of hair regeneration proteins.
Professor Sung said, "The results of this study will be a clue to effectively overcome the long incubation period and high cost, which have been pointed out as difficulties when developing adipose stem cells as cell therapy products. It is expected that additional research for three to five years will enable the development of cell therapy for hair loss treatment."
The results of the study were recently published in the online edition of the international journal Stem Cells in the field of stem cells.
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