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[Hair loss information] 2/17일자 탈모치료제 구글번역기 번역

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급한데로 구글로 번역했습니다...
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CRF에서 수용체 길항제 Astressin - B는 반대로
CRF에서에 방지 탈모증은 - 쥐를 표출 이상
Lixin Wang1., Mulugeta Million1 *., 진 Rivier2, 캐서린 Rivier2, 노아 Craft3, 메리 경찰 Stenzel - Poore4,
Yvette의 Tache '한
소화기 질환 1 본부, 의학, 치료 및 신경 생물 학적 스트레스에 대한 센터의학과, 캘리포니아 로스 대학에서 의학 Geffen 학교 데이비드
앤젤레스, 버지니아 그레이터 로스 앤젤레스 의료 시스템, 로스 앤젤레스, 캘리포니아, 미국, 펩타이드의 생물, 솔크 2 클레이튼 재단 실험실
생물 학적 연구를위한 연구소, 디에고, 캘리포니아, 미국, 피부과 및 감염증 3 사단, 의학 계열, 로스 앤젤레스 산
의료 센터 하버 - UCLA의 바이오 메디컬 연구소는 캘리포니아 로스 앤젤레스, 토랜스, 캘리포니아 대학에서 미국 의학 Geffen 학교 데이비드
미국의 분자 미생물학과 면역학, 오리건 보건 과학 대학, 포틀랜드, 오리건 4학과, 미국
추상
Corticotropin 단추, 계수 (CRF에서) 신호 전달 경로가 스트레스 반응에 관여 발표 증거가 성장하고있다
스트레스에 노출시 생체내 murine 모근까지 달린 머리카락의 머리카락의 성장 억제를 지원. 우리는 봉쇄 여부 조사
(히어로) phenotypes을의 표시 - 쥐 표현을 통해 CRF에 수용체의 CRF에 머리 빠지의 발전에 영향을 미친다
커싱 증후군과 만성 스트레스, 탈모증 등. 비 선택적 CRF에 수용체 길항제, astressin (B 조 5 밀리그램 /
마우스가) 4-9개월 5 일 동안 하루에 한 번 peripherally 착색과 머리를 유도 오래된 CRF에 - 히어로 alopecic 쥐 주입
크게 4 개월 이상 보관했다 다시 성장. 젊은 CRF에서 - 변 수인 oe 마우스에서 astressin - B는 개발의 방지
탈모증 그 식염수 - 취급 생쥐에서 발생했습니다. Histological 시험은 alopecic CRF에 - 변 수인 oe 생쥐 모근까지 달린 머리카락 있다고 지적
위축과 그 astressin - B는 위상을 anagen로 telogen에서 모근까지 달린 머리카락을 살려 냈죠. 그러나, astressin - B는 나타나지 않았어요
CRFOE의 상승된 혈장 corticosterone 수준 및 부신 분비의 증가 가중치과 내장 지방에 어떤 영향
생쥐. 선택적 CRF2 수용체 길항제는 astressin2 - B는 헤어 regrowth 아니라지만, 착색에 온건한 영향을 미쳤다.
탈모증, minoxidil에 대한 상업적인 마약은 머리가 다시 성장에 부분적인 효과를 보여주었다. 이러한 데이터를 지원
에 길항제와 주변 CRF에 수용체를 차단하는 계기로 핵심적인 분자 스위치 메커니즘의 존재
만성 스트레스와 연관된 탈모증의 마우스 모델에서 재설정 머리카락 성장.
인용 : 왕 패, 백만 월, 리어 일본, 리어 C 조, 공예 없음, 외. (2011) CRF에 수용체 길항제 Astressin - B는 반대 및 표현 이상 CRF에의 탈모증을 방지
쥐. PLoS 하나 6 (2) : e16377. 간접 자원부 : 10.1371/journal.pone.0016377
에디터가 : 마이클 Polymenis, & M은 미국의 대학, 미국 텍사스
수신 2010년 10월 8일; 허용 2010년 12월 13일; 게시 2011년 2월 16일
저작권 :? 2011 왕 외. 이것은 허가 크리에이 티브 커먼즈 저작자의 조건 라이선스에 따라 배포 오픈 액세스 문서입니다
무제한 사용, 유통, 재생산 어떠한 매체에, 원래의 작성자와 소스가 적립 제공됩니다.
자금 :이 작품은 연구 경력 과학자 상, 지원했다 재향 군인의 실무 계열 (Y를 Tache '); 다음과 같은 NIH 보조금 : R01 - 디케이
57,238 (Y를 Tache '); R21 디케이 - 068155과 RO1 디케이 - 078676 (엠 만), R01 디케이 - 33061 (Y를 Tache', 엠 백만), P50 디케이 - 64539 (Y를 Tache ', 엠 ) 만; 디케이 PO1 - 26741 (제이
리어). funders는 연구 설계, 자료 수집과 분석, 게시 결정, 또는 원고의 준비에 역할을했다.
관심 분야가 경쟁 : 저자는이 저널의 정책을 읽고 다음과 같은 충돌이 : JR은 창립자, 주식 소유자, 사장, 그리고 과학적인 의자입니다
Sentia 의료 과학 자문위원회는 주식 회사 Sentia는 astressin B 및 analogs에 대한 솔크 연구소 (미국 특허 번호 6,323,312로부터 독점 라이센스를 가지고
5,874,227, 5,777,073 및 7,141,546). 이것은 모든 PLoS 데이터 공유 및 자료에 대한 한 정책 작성자의 준수를 변경하지 않습니다.
* 이메일 :
. 이 작가가이 작품에 똑같이 기여하였습니다.
소개
절반 이상이 한 세기 전, 한스 Selye,의 아버지
그 '강렬한 심령 충격을 언급한 생물학 스트레스 개념,
또한, 예 및 회어지는, 머리에 발음이 효과를 발휘 있습니다
머리 '' [1]의 일반 상실. 누적 후속 실험
임상 증거가 만성 스트레스가 미치는 것을, 실제로 나타내는
머리카락의 성장에 깊은 억제 효과는 [2-5]을. Corticotropinreleasing
계수 (CRF에서), adrenocorticotropic 호르몬 (ACTH)과
glucocorticoids뿐 아니라 내분비 계의 핵심 구성 요소이며
neuroimmune 응답 스트레스뿐만 아니라 그들에게 방해가 머리를
인간과 생쥐의 뿌리 성장주기 [2,3,6,7]을. 교양 있음
인간의 두피 모낭, 최대 단추 proopiomelanocortin의 전송을 조절 CRF에
(POMC)와 ACTH 및 immunoreactivity
- melanocyte - 자극 호르몬 (MSH), 그리고 증가 코르티솔
분비가 [5]. Slominski 외. [8,9]도 CRF에 그 나타났습니다
urocortin 1과 CRF의 수용체는 1과 2 (CRF1 및 CRF2) subtypes
정상적인 피부와 사이클링 모낭의로 표현됩니다
인간과 생쥐.
마우스가 오버 특급 CRF에서 (CRF에 - 변 수인 oe) 특징 것으로
의 phenotypes를 캡처 만성 스트레스를 모델로
, 내분비, 면역, 자율 행동 및 내장
커싱 증후군의 발현 옆에있는 변경은 [10-16]을.
특정 대상에 의해 생성된 마우스 돌연변이 다수 있지만
모근까지 달린 머리카락주기에 관련된 경로 또는 누드 생쥐의 결과
염증 탈모증의 모델 [4,17,18]를, CRF에서 - 변 수인 oe 마우스
모델 stressinduced 만성 관련된으로 지금까지 검사되지 않았습니다
초기 보고서에도 불구하고 탈모증, 그 CRF에 - 변 수인 oe 마우스
성인 [11]에 양자 대칭 머리 손실을 개발할 수 있습니다.
만성 스트레스는 머리카락의 성장을 impairs되는 기존의 증거에 근거해서
그리고 CRF에서 시스템의 주요 구성 요소가 표현되는
마우스와 인간의 피부는 우리은 CRF의 능력을 조사, [9,19]을
수용체 antagonists은 CRF - 변 수인 oe에 머리 손실을 /를 다시 성장에 영향을
생쥐. 우리는 CRF에 의해 수용체를 차단 여부를 평가 단기
긴 연기 펩티드 CRF1/CRF2와 말초 치료
수용체 길항제, astressin - B 호 [20]는 머리가 다시 성장을 일으킬 것이다
성인 alopecic CRF에 - 변 수인 oe 생쥐에 착색이되지 않도록
젊은 CRF에서 - 변 수인 oe 생쥐에 탈모증의 개발. 우리는 또한
PLoS 하나 | 2011년 2월 1일 www.plosone.org | 볼륨 6 | 제 2 호 | e16377
머리에있는 CRF에 길항제 동작의 특이성을 조사
성장이나 또한 높은 플라즈마 corticosterone에 영향을 미칠 것인 지에
수준의 비대와 같은 다른 커싱 같은 phenotypes (
부신 분비 증가 지방 예금) [11]. 마지막으로, 우리는 테스트
비슷한 조건 하에서 선택적 CRF1 아닌 수용체 여부
펩타이드 길항제, NBI 27914 [21], 선택적 수용체 CRF2
펩타이드 길항제, astressin2 - B 호 [22] 또는 상업적인 마약, minoxidil
머리카락의 성장 및 착색에 [23] 효과 발휘.
결과
비 선택적 CRF1/CRF2 길항제, astressin - B 호
주입 intraperitoneally (IP)을하거나 subcutaneously (사우스 캐롤라이나)
CRF에서 - 변 수인 oe 생쥐에 탈모증이 반대
그들이 때 남성과 여성의 CRF에 - 변 수인 oe 생쥐 탈모증을 개발
4개월보다 이전. 식염수는 IP inmale CRF에 - OEmice 아니야 주입
탈모증에 영향이있다 : 피부 색깔은 분홍색없고 남아
머리가 감시 기간 (Figs. 1A는 및 2A입니다, B)를 전체로 퍼져나 갔으며. 로
반면, CRF1/CRF2 수용체 길항제, astressin - B 호 주입 IP를
5 밀리그램 / 마우스에서 5 연속 일 동안 하루에 한 번 결과
처음에는 분홍색 alopecic 피부 사이에 어두운 안료 개발
4개월 늙은 남성 CRF에 - 변 수인 oe 생쥐의 마지막 주사 삼일 후에
(그림 1B). 동시에, 색소는 최대한의로 증가로
70-10일 (그림 2A입니다) 이내에 응답이 밖으로 성장하는데 유독 머리카락과로 증가
이주의 머리 보상 범위 95~100% (와 전체 길이 Figs. 1C과
2B 요). 다시 자란 머리는 다음 18 주 동안 유지되었다
(그림 2B 요)를 누른 다음 주로 4개월에 게시 분사를 유지
생쥐 (데이터가 표시되지 않음) euthanized 때. 마찬가지로, astressin - B 호
(5 밀리그램 / 마우스) 피부 색소를 유도 오일에 대해 하루에 한 번 사우스 캐롤라이나 주입
4-9개월 이전의 80 %에서 마지막 주사 후 일주일 이내에 후
alopecic 여성과 남성 CRF에 - 변 수인 oe 생쥐 (그림 3B 라, G 조). 생쥐 회복
2-4주 게시물 치료 (그림 3A의 - C 조, H 조)에 50~90% 머리 범위.
하루에 한 번 반면, astressin2 - (5 밀리그램 B의 사우스 캐롤라이나 주입 / 마우스
연속 5 일) CRF에 - 변 수인 oe에 머리 성장을 유발 않았어
낮은 학년지만 상당한 착색 비록 생쥐 (그림 3E - H 조)
(그림 3 세대)가 발생했습니다. 마찬가지로, CRF1 길항제, NBI
27914이 (0.5 밀리그램 / 마우스) 5의 5 일 동안 하루에 두 번 사우스 캐롤라이나 주입
개월 된 여성 CRF에 - 변 수인 oe 마우스는 어떤 머리 regrowth를 유도 않았어
(데이터가 보이지 않음).
CRF에서 - 변 수인 oe 생쥐의 피부 형태학의 변화가 주입
intraperitoneally astressin - A와 B
Histological 평가는 머리에 모공 것으로 나타났다
CRF에서 - 변 수인 oe 생쥐 (7 개월, 남) 주입 IP에서 alopecic 피부
그림 1. CRF1/CRF2 수용체 길항제는 astressin - B 호, intraperitoneally (IP)을 CRF에 - 변 수인 oe 생쥐에서와 완벽하게 개발된 주사
탈모증은 머리 성장 및 착색을 유도합니다. 사진 : 행 : 남자 CRF에 - 변 수인 oe 생쥐 (4 개월) 주입 IP를 한번 5 매일
astressin - (5 밀리그램 / 마우스) 삼일에서 마지막 IP 주입 후, 및 B 행에 C : : 마지막으로 주사하고 B 조 행 후 3 일 식염수에 연속 일
마지막 IP 주사 후 사주에있는 중간 패널 행 B에 같은 생쥐.
간접 자원부 : 10.1371/journal.pone.0016377.g001
CRF에서 수용체 길항제를 차단 탈모증
PLoS 하나 | 2011년 2월 2일 www.plosone.org | 볼륨 6 | 제 2 호 | e16377
식염수 (그림 2 차원)로에 비교하여 비정상적 형태를했다
WT의 littermates (그림 2C). 머리 뿌리의 길이
CRF에서 - 히어로의 생쥐가 크게 WT에 비해 짧은했다
(0.3760.03 대 0.5460.03 mm, n은 5/group; 피, 0.05). IP의
astressin - B 조 - 처리 CRF에 - 변 수인 oe 마우스, 모근까지 달린 머리카락의 개혁였다
및 치료 (그림 2E) 2 주 후 본 머리가 모공
(그림 2 차원, 전자) 단계를 anagen 위해 telogen로 변경되었습니다.
모낭의 평균 길이가 0.4260.05 mm (없음 = 5) 및되었습니다
더 이상 크게 WT의 littermates에있는 것과 다른.
다른 intraperitoneal astressin - B의 효과 부족
CRF에서 - 변 수인 oe 생쥐에 커싱 증후군의 특징
CRF에서 - 히어로의 마우스는 (4~7개월 노인, 여성) 상당한 3.9 있었
WT의 littermates으로보다 배 이상 혈장 corticosterone 수준
마지막 IP 식염수 주입 (그림 4A 및) 후 7 일 평가.
Astressin - B 호 (5 밀리그램 / 마우스) 5 일 동안 주사 IP를 탈모증을 바꿔서
하지만의 상승된 혈장 corticosterone 수준을 수정하지 않았어
일 중 하나에서 CRF에 - 변 수인 oe 생쥐, 즉, 일 1, 3, 7 및 모니터
마지막 IP astressin - B 호 사출 (그림 4A 및) 14 후. 또한,
부신 땀샘과 내장 지방의 무게가 상당히 큰 있었다
CRF에서 - 변 수인 oe에 WT 생쥐에 비해, 그리고 변경의 IP astressin - B 조로
주사로 지난 펩타이드 후 7 일 및 14 일에 모니터
주입 (그림 지하 4 층에서, C 조).
Astressin - B는 젊은 CRF에 - 변 수인 oe 생쥐에 subcutaneously 주어진
탈모증의 개발 방지
작은 머리와 영 CRF에 - 변 수인 oe 쥐 (생후 7~8주,여)
손실의 70~100% 영역에 식염수 개발한 탈모증과 사우스 캐롤라이나 주사
주사 후 8-16주 (그림 5J) 동안 다시. 로
반면, 젊은 CRF에 - 변 수인 oe 생쥐 (와 astressin - B와 사우스 캐롤라이나 주입 5
) 5 일 / 마우스 / 하루 밀리그램 한 이내에 피부 착색 표시
주 지난 사출 (그림 5I), 후에 머리 손실로부터 없었어요
다음 2 개월 뒤 평균 70 % 유지
4 개월 관찰 기간이 포스트의 끝에 머리
주입 (그림 5A - D를, 일본). 반면에, 사우스 캐롤라이나는 astressin2 - Binjected
CRF에서 - 히어로의 마우스는 피부의 중간 유도를 보여주
첫 주 게시물 주입 (그림 5I) 중에 안료,하지만 지속
식염수 - 처리된 생쥐 (그림 5.E - H에, 일본)로 비슷하게 머리를 잃을 수 있습니다.
minoxidil의 영향은 CRF - 변 수인 oe 생쥐에게 주어진 subcutaneously
탈모증과
1 % minoxidil 황산 솔루션의 행정 (0.1 랑 MI /
마우스,) 10 일 동안 하루에 한 번 5개월 오래된 사우스 캐롤라이나 alopecic 여성
CRF에서 - 히어로의 생쥐가 지난 후 안료 이주의 패치를 유도
4 대우 CRF에 - 변 수인 oe 쥐 중 3과 중간에 주사
색소 패치에 머리 성장은 2와 4에서 관찰되었다
지난 주사 주 후에 차량 주입은 효과가 있었을 때
(그림 6).
토론
현재 실험 보여, 그날은 CRF에 - 변 수인 oe 생쥐에
모두 CRF1과 CRF2 수용체의 탈모증, 봉쇄와 함께
펩타이드 CRF1 및 intraperitoneal 또는 피하 주사
CRF2 수용체 길항제는 astressin - B 호 [20]은 강력한 피부를 유도
착색과 헤어 다시 성장. 또한, 젊은 안에 아직
alopecic CRF에서 - 변 수인 oe 마우스, astressin - B는 머리카락의 손실을 방지할 수 있습니다. 놀라운,
머리가 다시 성장과 함께 관찰되면서 작은 5 일일 싱글로
/ 마우스 5 밀리그램의 주사. 이 연구는 또한 증거를 제공 CRFOE 그
생쥐 관련 모델의 특징은 탈모증 공부를 표시할 수 있습니다.
그림 2. 피부 안료 점수 (A)를, 헤어 성장 평가 점수 (B)와 남성 CRF에 - 변 수인 oe 쥐의 피부 photomicrographs (의 C - 전자) (7 개월)
astressin - (5 밀리그램 / 마우스) B 또는 식염수에 연속 5 일 동안 하루에 한 번씩 주사의 IP. 데이터의 개별 및 중앙 분리대하고 6 건
의 IP 주사 0.05 대 전에 B 조, 피,에 현미경. Photomicrographs 남성 야생 유형의 뒤에 피부에 머리카락 뿌리의 형태를 (규모 100mm) 표시
생쥐 (C)와 식염수 (D 조) 또는 astressin - B 호 (전자)의 마지막 IP 주사 후 2 주에서 CRF에 - 변 수인 oe 쥐. 화살표를 각각의 패널에서 모근까지 달린 머리카락을 나타냅니다.
간접 자원부 : 10.1371/journal.pone.0016377.g002
CRF에서 수용체 길항제를 차단 탈모증
PLoS 하나 | 2011년 2월 3일 www.plosone.org | 볼륨 6 | 제 2 호 | e16377
Astressin - B 호의 작업은 모두 CRF1과 CRF2의 봉쇄를 포함 수 있습니다
그 [8,24] 모낭을 포함 murine 피부로 표현됩니다. 이
데이터에 의해 지원되는지 어느 긴 행동 선택적 CRF2
길항제, astressin2 - B 호 [22]이나 선택적 CRF1 길항제, NBI
혼자 주어진 27914 [21]는 머리카락의 성장에 효과가 있었을 때
외인성 CRF에 또는 차단 복용에 subcutaneously 관리
urocortin 한 행동 [22,25]을. 마찬가지로, 젊은 CRF에 - 변 수인 oe 쥐에서,
astressin - B의 피하 주사가 개발의 방지
이후 몇 주 / 시간 모니터링 개월 탈모증.
그러나, 식염수 및 astessin2 - B 호 처리 CRF에 - 변 수인 oe 쥐 개발
CRF2 수용체의 선택적 차단하여 비록 전체 탈모증
astessin2 - B는, 온난한와 브리핑 증가 착색 결과.
추가적인 연구가 CRF에의 각 역할을 평가하기 위해 필요합니다
머리가 다시 성장 및 착색에 대한 수용체 subtypes. 특히
다른 먹이지 regimens 여부 CRF1 또는 CRF2 선택적
antagonists는 머리카락의 성장에 대한 효과를 측정하고 유도
착색뿐만 아니라 분자 (들)과 세포의 식별에
그 효과는 더 연구를 필요로 어느 astressin - B와 역할을 트리거합니다.
관계없이 현재 데이터의 첫 번째 증거를 제공
힘 및 효능 astressin - B의 유도에 peripherally 주사
장기 반전이나 CRF에 - 변 수인 oe 생쥐에 탈모증의 예방.
이러한 murine 데이터은 CRF agonists의 영향과 일치 또한
인간의 머리카락 뿌리의 신장에 antagonists는 [5].
astressin - B 조은 CRF - 변 수인 oe 생쥐에 주입 peripherally 이었기 때문에, 그것
관찰된 효과뿐만 아니라으로부터 결과가 발생할 수 있습니다
액션뿐만 아니라 해로운 효과를 그 감소를 통해 지역
뇌하수체와 부신 분비의 만성적인 조직의 활성화
피부 착색과 머리를 다시 성장 [2,3]에 할 수 있습니다. 사실,
adrenalectomy은 CRF에 - 변 수인 oe 생쥐에 탈모증 순서를 반대로 표시되었다
[11]. 그러나, 현재의 연구에서 우리는 변화를 감지하지 않았어
각 시간에 CRF에 - 변 수인 oe 생쥐에 상승 corticosterone 플라즈마 수준
포인트 astressin - B의 종료 후 일 1, 3, 7 및 14 일에 모니터
치료. 이러한 데이터는 이전 pharmacokinetic 일치
보여주는 그 연구의 만성 자극 미만
hypothalamic - 뇌하수체 축, astressin - B는 peripherally 주입
24 동안 12 H 조 H 조에 대한 고가 ACTH 플라즈마 수준 차단
게시물 분사 값을 다시 [20] 차량 분들됩니다. 또한,
CRF에서 길항제는 하루에 한 번 단일 주사로 받았어요
전용 오일은 아직 다시 자란 머리 쥐의 대부분에
최대 몇 개월 위해 유지됩니다. 탈모 방지
게시물 치료는 여전히 3-4개월 주목할했다. 따라서,
adrenals의 절제가 CRFOE의 탈모증을 반전이지만
마우스 [11], 그 사실 astressin - B 호, 팬에 사용하는 처방에서
플라즈마 영향을주지 않고 탈모증에 대해 같은 극적인 효과
가능성은 주변 걸 corticosterone 수준 규칙
astressin - B의 주입은 ACTHFigure의 영구적인 억제에 미치는
3. CRF1/CRF2 수용체 길항제의 피하 (사우스 캐롤라이나) 주입, astressin - B는 CRFOE에 착색과 머리카락의 성장을 유도
탈모증와 생쥐. 6~9개월 늙은 남성 또는 여성 CRF에 - 변 수인 oe 쥐 그룹을 하루에 한 번씩 5 일 연속 두와 사우스 캐롤라이나 주입했다
astressin - B 호 (5 밀리그램 / 마우스) 또는 astressin2 (/ 마우스 5 밀리그램) B 조. - C 조 : (A)를하기 전에 1 (B)와 사주에 완전 alopecic 여성 CRF에 - 변 수인 oe 마우스 (C 조, 90 함께 %
머리 범위)는 지난 사우스 캐롤라이나 astressin - B와 주사를 다음과. 디 - f : 시스템을 마지막으로 사우스 캐롤라이나 주 후 (D)를하기 전에 1 (전자) 또는 사주 (F 조)에서 완전 alopecic 남성 마우스
머리카락을 다시 성장과 astressin2 - B의 주사. G 조 : 마지막으로 사우스 캐롤라이나 주사 후 주사의 시작 1 주일 전에 피부 착색의 점수; H 조 :
헤어 성장 점수의 시간 코스와 마지막 사우스 캐롤라이나 사출 최대 4 주 후에 전에. 데이터가 G 조의 개별 및 중앙 분리대하고 헤 * 피 6 현미경을 0.05 말은
주일 대 0 (G와 H 조), # 피, 0.05 대 astressin2 - 해당 주 (G 조) 및 (H 조)에서 B 조.
간접 자원부 : 10.1371/journal.pone.0016377.g003
CRF에서 수용체 길항제를 차단 탈모증
PLoS 하나 | 2011년 2월 4일 www.plosone.org | 볼륨 6 | 제 2 호 | e16377
이러한 오랜 기간 동안 corticosterone 폭포. 이 현상이 더 있습니다
시위에 의해 지원되는 짧은 기간이지만
헤어 regrowth 유도된 astressin - B와 치료, 이건 다른 영향을 미치지 않았어
증가 무게와 같은 증후군과 같은 발현을 커싱
부신 땀샘과 CRF에 - 변 수인 oe에 복부 지방 예금.
astressin - B 호 주입 IP 또는 사우스 캐롤라이나의 파업 효과 중 하나는 살
몇 일 이내에 피부 / 헤어 안료의 강력한 유도는 다음과 같은
오일 트리 트먼트 처방. CRF2의 마찬가지로, 사우스 캐롤라이나 주사
수용체 길항제는 astressin2 - B 호 피부의 일부를 유도 유도
착색보다 너무 젊은에 alopecic CRF에 - 변 수인 oe 쥐보다시
치료 후 일주. 헤어 안료는 컨트롤의 아래에있다
neuroendocrine, neurotrophins, melanocortin 등 복잡한 시스템
수용체 신호, 멜라닌 합성과 멜라닌
수송 및 정관 머리카락 샤프트에 [26,27]을 keratinocytes.
CRF에서, POMC, ACTH 및 corticoids 등 여러 가지 요인,
모근까지 달린 머리카락의 활동을 해제 또는 터닝에서 역할을
melanocytes은 [27,28]을. 흥미롭게도, 피부 melanocytes 응답
CRF에서 생산하여 UVB 환경 스트레스와 같은
[29]. CRF1과 CRF2 수용체는 differentially과 표현됩니다
인간과 murine 모근까지 달린 머리카락의 색소에 별개의 기능 발휘
단위는 [6,8,30,31]을. Urocortin 1, CRF에의 포유류의 회원
CRF에서보다 CRF2 수용체에 높은 친화력과 펩타이드 가족
다운 melanocyte 차별의 표현형은 [30]을 조절. 사실
그 착색 머리카락의 유도와 함께 발생
astressin - B 조 - 처리 생쥐의 성장은 데이터와 계약에
그 melanogenesis 엄격하게 헤어 성장 단계를 anagen하는 결합이다
[32]. 따라서, CRF에의 overexpression은 melanocyte 활동을 억제 있습니다
astressin - B 조로 CRF에서 수용체의 봉쇄 반면 켜지 그들의
활동 / 헤어 피부 착색을 일으킬 수 있습니다. 콘트라스트, 억제에 의해
astressin2 - B 호에 의해 CRF2 수용체가 부분적으로만 활동을 자극.
엄청난 보폭은 이해에 제출 했음에도 불구하고
머리카락의 성장과 탈모증의 세포 메커니즘을 근본의
실험 모델의 소수가있다 특히
만성 스트레스와 관련된 탈모와 그 해결에 관한.
사실은 만성 스트레스를 CRF에 - 변 수인 oe 생쥐가 alopecic 될 것을
성인기는 스트레스와 관련된 인간의 머리카락 손실 연상
[33]. 이지만 CRF에서 - 변 수인 oe 생쥐에 탈모증은 주로 영향을
, 뒤로 국한되지는 않습니다. 또한 그것은 치료에 반응입니다
비 선택적 같은 길이로, CRF에 수용체 길항제 행동
minoxidil에 낮은 범위, 연방 정부 승인을 몇 가지 중 하나
탈모증의 임상 치료 [21]합니다. 이러한 결과 제안 그
CRF에서 - 변 수인 oe 생쥐의 탈모증은 인간에서 본 일부 기능을 공유할 수 있습니다.
CRF에서와 지속적인 높은 수준 CRF에서 - 변 수인 oe 쥐
corticosterone 및 탈모로 현재와 이전의 연구에서 본
[11] 좋은 얼굴을 가지고 있고 관련성이 높은 모델과 타당성을 구축
탈모증은 따라서 해명 수있는 독특한 기회를 제공합니다
만성 스트레스와 관련된 탈모에 경로.
총칭, 우리가 보여준 그의 주변 장치 봉쇄
astressin - A와 B CRF1과 CRF2 수용체가 peripherally 주입
중 피하 또는 intraperitoneally 다섯 경기를 연속 일간
5 밀리그램만큼 낮은 복용량에 / CRF에 - 변 수인 oe 마우스 피부를 활성화
alopecic 생쥐에 착색 및 머리카락 성장과 머리카락을 방지
젊은 CRF에서 - 변 수인 oe 생쥐의 손실. CRF에의 임시 봉쇄
수용체 따라서 탈모증에 대한 획기적인 치료 될 수
급성 (화학 요법 환자, 외상 특히
스트레스 행사) 또는 만성 스트레스 설정. 또한, 현재
결과은 CRF - 변 수인 oe 생쥐 관련 모델에 될 수 있음을 나타냅니다
만성 스트레스와 관련된 탈모 우리의 이해를 전진.
재료 및 방법
윤리 선언문
이번 연구는 설치류의 사용을 참여. 모든 실험이 있었다
에 따라 수행 관련 국제 및 국가
실험 동물의 사용에 대한 지침. 모든 절차가 있었다
베테랑 담당 그레이터 로스 앤젤레스 의료의 승인을
시스템 동물 연구위원회 (프로토콜 04012-06, 9906 -
820과 11084-03).

여성 CRF에서 - 변 수인 oe 남성과 야생 유형 (WT) littermates였다
C57BL / 6 엑스 SJL에서 발생한 유전자 변형 라인에서 파생된
그림 4. Astressin - B는 주입 intraperitoneally (IP)을하지 않습니다
영향을 미치는 플라즈마 corticosterone (), 부신 (B)와
여성 CRF에서 - 변 수인 oe 생쥐에서 내장 지방 무게 (주) (4-7개월
이전). 각 막대는 뜻 6 SEM을을 (n은 5/group 또는 시점)을 나타냅니다.
* 피, 0.05 대의 WT.
간접 자원부 : 10.1371/journal.pone.0016377.g004
CRF에서 수용체 길항제를 차단 탈모증
PLoS 하나 | 2011년 2월 5일 www.plosone.org | 볼륨 6 | 제 2 호 | e16377
에 10 세대 이상의 backcrossed되었습니다 배경
로 C57BL은 / 6 이전 키메라 CRF에의 transgene를 사용하여 상세한
쥐를 CRF에 운전 methallothionein - 1 프로 모터로 구성된
유전자가 [11]. 쥐들이 제어 온도 아래에 위치해 있었다
(21 - 23uC), 습도 (30~35%)과 가벼운주기 (오전 6시 6:00
오후) 및 표준 설치류 다이어트 (Prolab RMH에 유지
2500, LabDiet, PMI 영양학, 브렌트우드, 미주리).
물질
Astressin - B 및 astressin2 - B 호 (펩타이드 생물학 연구소,
솔크 연구소는, 라 Jolla, CA)의 견고한 위상을 사용하여 합성했다
접근과 Boc - 전략으로 이전 [20,22]과 설명
280uC에 분말 형태로 저장됩니다. 바로 앞
실험은, 펩티드는 멸균 물 (산도 7.0)에 녹아 있었다.
NBI - 27914는 (Tocris, Ellisville 미주리) 에탄올, 십대 초반에 해산되었다
80 [1:0.5:8.5 (브이 / v) 본, 산도 5.0]을 식염. Minoxidil 황산 소금
(이 시그마 - 올드 리치 공동, 세인트 루이스, 미네소타) 1시 2분 7초 (/ 브이 브이)에 해산되었다
에탄올, 폴리에틸렌 글리콜과 염분, 각각, 산도 5.0.
헤어 성장 및 착색 측정
머리 성장의 모니터링은 기본적으로으로 설명되었다
Vegesna 외. [34]. 따라서 점수는뿐만 아니라 시각되었다
주간 간격으로 각 마우스의 사진을 사용합니다. Hairgrowth
CRF에서 - 변 수인 oe 뒤쪽에 지느러미 지역에서 관찰되었다
생쥐 어느 완전히 발달 탈모증 (나이 4달러 개월) 말거나
아직 (# 8 주) 탈모증을 개발했습니다. 이 지역은 정의된
뒤로 귀의 전면 기지에 합류 라인, anteriorly로
골반 환상 골의 전면을 따라 라인으로하고 측면으로
라인은 각 귀에 기지에서 caudally 예상. 제로 점수
테스트에 머리카락의 양을의 변화에 대응
alopecic 영역 및 전체에서 전체 머리카락의 성장에 10의 점수
alopecic 공간이 있습니다. 브리핑에서, 퍼센트 그 지역의 머리카락으로 덮여 있습니다
위에서 구분된 영역에 해당하는 0-10 사이의 점수는
시험 영역의 000~100%의 머리 범위.
테스트 지역에서 피부의 착색도 측정되었다
왜냐하면, C57BL / 6 마우스에서, 머리카락의 발병에 피부가 짙어
성장. 00-10에서 착색 점수는 각 마우스받은
0 : : 밝은 분홍색 피부 색깔 / 안료; 1-5 테스트 지역 :
엷은 잿빛 컬러 / 피부의 색소의 강도를 증가; 6-9 :
하지만 비 합류 증가 어두운 색 피부 / 안료; 10 :
전체 시험 영역 위에 검은 착색. 착색였다
마지막 주사 후 일주 평가 있기 때문에 변경 사항 (있을 경우)
착색에 실질적으로 그 당시에 의해 완료됩니다.
피부 조직학
CRF에서 - OE 및 WT 마우스 (남, 7 개월)와 주사의 IP
식염수 또는 5 연속 일 astressin - B 호 (5 밀리그램 / 마우스)되었습니다
과다의와 마지막 주사 후 euthanized 이주
그림 5. CRF1/CRF2 수용체 길항제는 astressin - B는 subcutaneously 주입 (사우스 캐롤라이나) 착색을 유도하고 탈모를 방지
와 젊은 CRF에서 - 변 수인 oe 생쥐에 아직 탈모증을 개발 없습니다. 사진 : 주사 전 대표 CRF에 - 변 수인 oe 암컷 쥐 (, 전자)와 같은 생쥐
4, 8 및 16 주 후에 astressin - B 호 (B 조 - C 조) 또는 astressin2 - B는 (F 조 - H에) / 마우스 5 밀리그램에서 5 연속 일 동안 하루에 한 번씩 사우스 캐롤라이나 주입했다. 그래프 나 : 그리고 개인
(주 0)하기 전에 피부 착색 점수의 평균 가치와 치료 후 일주. * : 주 0 식염수의 P, 0.05 대 그룹 주 1; # :
피, 0.05 대 astressin2 - B 호, 그래프 일본 : 치료 후 (주 0)와 1, 4, 8 및 16 주 전에 헤어 성장 점수. 각 지점이 평균 6를 나타냅니다
SEM을. * : 이전과 이후 피, 0.05 대 주간 0; # : 피, 0.05 대 astressin2 - B 또는 식염수 해당 주에.
간접 자원부 : 10.1371/journal.pone.0016377.g005
CRF에서 수용체 길항제를 차단 탈모증
PLoS 하나 | 2011년 2월 6일 www.plosone.org | 볼륨 6 | 제 2 호 | e16377
나트륨 pentobarbital (5 mg/0.1 랑 MI / 마우스, IP를; NembutalH,
애보트 래버러토리스, 시카고, 일리노이, 미국)과 피부 샘플 있었다
뒤로 (alopecic 영역)에서 얻은 4에서 수정된 %
paraformaldehyde. 파라핀 - 임베디드 섹션에 대한 처리되었습니다
hematoxylin은 /는 eosin 염색법과 현미경에 빛을 조사
(자이스 혈구의 Axioskp 2). Photomicrographs가 디지털에 인수했다
이미지 수집을 사용하는 카메라 (하마 마츠, Bridgewater, 뉴저지)
시스템 SimplePCI (하마 마츠 공사, Sewickley 펜실바니아).
모근까지 달린 머리카락의 길이는 NIH 일본 이미지를 사용하여 측정되었다
버전 1.42.
혈장 corticosterone 수준, 부신 및 내장
지방 중량 결정
CRF에서 - 변 수인 oe 마우스 및 WT littermates (, 4-7 개월 된여)
와 (0.1 랑 MI) IP를 주입했다 astressin (/ 마우스 5 밀리그램) 또는 식염 B 조
일일 오일과 euthanized 7 일 지난 식염수 분사 또는 게시
astressin - B의 마지막 주입 일 1, 3, 7 번 또는 14시 이후. 혈액형은
생쥐로부터 미만 금방 마음에서 수집된
pentobarbital 나트륨 (/ 마우스 5 mg/0.1 랑 MI와 anesthetized
IP)을. 플라즈마는 즉시 격리되어 280uC에 저장된까지
분석. 혈장 corticosterone 수준 Immunochem로 측정되었습니다
난 - 125 corticosterone 리아 키트 (ICN 의생명 주식 회사, 코스타
메사, 캘리포니아). 분석 이전 [35,36] 생쥐에서 확인되었다. 에
7 일 이후 마지막 주입, 혈액 수집 이외에, 부신
아래쪽 복부 및 골반의 땀샘과 내장 지방이되었습니다
CRF에서 - OE 및 WT 마우스에서 수확과에 무게
0.1 밀리그램 가까운.
실험 프로토콜
CRF에서 - 변 수인 oe에 CRF에 수용체 antagonists (1) 트리 트먼트
탈모증와 생쥐. 오래 지속 펩타이드가 아닌 선택
CRF에서 수용체 길항제, astressin - B 호, 선택적 CRF2 수용체
길항제, astressin2 - B 호 [20,22] 또는 멸균 isotonic 염분였다
역시 IP를 주입 또는 5 일 동안 하루에 한 번 5 mg/0.1 랑 MI에서 사우스 캐롤라이나 /
여성과 남성 CRF에 - 변 수인 oe 생쥐에서 마우스 (4~9개월 이전)와
개발 탈모증. astressin -와 B astressin2 - B의 복용이 있었다
반대로 생쥐 우리의 이전의 연구를 기반으로 선정
[22,25] CRF에서 IP의 생물 학적 기능. 착색 및 머리
보도 점수는 첫 번째의 시작하기 전에 결정
분사와 1, 4 8 주 (IP를 주입 실험)시
마지막 (사우스 캐롤라이나 분사 실험) 1, 2, 사주에 후
주사.
그림 6. 1 % minoxidil의 효과는 CRF에 - 변 수인 oe 생쥐에서 탈모증에서 (사우스 캐롤라이나) subcutaneously 주입 황산. 5개월의 그룹 옛 CRF에 - 변 수인 oe 쥐
10 일 중 차량 또는 minoxidil 황산 (1 밀리그램 / 마우스)와 사우스 캐롤라이나 주입했다. 헤어 성장 점수가 지난 후 1, 2, 사주에 모니터됨
주사. : (주 0)하기 전에 주 2와 4에서 치료 후 머리카락 성장 점수. 각 지점이 평균 6 SEM을, n은 5/group를 나타냅니다. B 조 - 이메일 :
(B 조 & D)를하기 전에 차량 (C 조) 또는 minoxidil (바)의 마지막 주사 후 사주에 CRF에 - 변 수인 oe 생쥐의 대표적인 사진.
간접 자원부 : 10.1371/journal.pone.0016377.g006
CRF에서 수용체 길항제를 차단 탈모증
PLoS 하나 | 2011년 2월 7일 www.plosone.org | 볼륨 6 | 제 2 호 | e16377
선택적 CRF1 - 비 펩타이드 수용체 길항제, NBI -
27,914 (0.5 밀리그램 / 사출 / 마우스) 또는 차량 [1:0.5:8.5 (브이 / 브이)의
에탄올, 십대 초반 - 80은 식염, 산도 5.0]는 여성 사우스 캐롤라이나에 맞았습니다
CRF에서 - 변 수인 oe 마우스 (5 개월) 5 연속 일 동안 하루에 두 번.
NBI - 27914의 처방은 우리의 이전에 따라 선정
연구 [37]을. 피부 안료 및 머리카락 성장으로 모니터링되었습니다
astressin - B의 사우스 캐롤라이나 주사와 실험.
(2) 예방 탈모증의 CRF의 수용체와 antagonists
젊은 CRF에서 - 변 수인 oe 생쥐에서 아직 개발되지 함께
탈모증. 젊은 여성 CRF에서 - 변 수인 oe 생쥐 (7-8주 이전)를
아직 개발하지 않았 탈모증은 astressin - B 호와 사우스 캐롤라이나 주입했다
astressin2 -, B 조 또는 식염수, 위에서 설명한 것처럼. Littermate WT 마우스
제어으로 재직했습니다. 피부 안료 및 탈모가 두 번 모니터링되었습니다
초기 주사를 따라 처음 2 주 동안 일주일에 한 번
주 최대 2 개월까지, 및 월별 이후.
(3) 치료 CRF에 - 변 수인 oe에 minoxidil과 탈모증의
생쥐. 여자 CRF에서 - 변 수인 oe 생쥐 (5 개월) 접수 사우스 캐롤라이나 매일
1 % minoxidil 황산 (1 밀리그램 / 마우스), 또는 차량의 주입 [1시 2분 7초
10 연속 용 (브이 / v) 본 에탄올, 폴리에틸렌 글리콜과 염분]
일. minoxidil 행정부의 처방이에서 선택되었다
다른 헤어드라 재 성장 촉진을 보여주는 이전 연구
탈모증의 모델 [38]을. 피부 안료 및 머리카락 성장했다
로 astressin - B의 사우스 캐롤라이나 주사를 다음과 같은 이상 모니터링.
통계 분석
결과는 6 SEM을하거나 중간 뜻으로 표현됩니다. 비교
헤어 성장 반응의 전과 동일한에서 치료 후
동물 사용하여 만들어진 이전 조치 이점 t - 테스트 후
피부 안료 점수는 맨 - 휘트니를 사용하여 분석하는 동안
합계 테스트를 순위. 머리카락이 서로 다른 그룹 간의 비교
성장 응답뿐만 아니라 플라즈마 corticosterone, adrenals과
낮은 복부 내장 지방 무게도를 사용하여 수행되었습니다
편도 ANOVA는 학생 뉴먼 - Keuls 방법 다음
테스트 또는 학생의 T - 테스트는 두 그룹이 값을 의미 비교.
그룹 사이의 피부 색소의 차이를 사용하여 비교했다
Kruskal - 월리스, 계급에 분산 편도 분석. 피, 0.05
중요한 여겨졌다.
응답
우리는 그녀의 뛰어난 기술 지원을 부인 Honghui 리앙 감사합니다.
저자 기부
MM은 LW YT 주니어 노스캐롤라이나 : 임신과 실험을 설계했습니다. 수행
실험 : LW 음. MM은 LW 생명체 노스캐롤라이나 : 데이터를 분석했다.
YT 주니어 생명체 의원 - 피 : / 분석 도구 / 재료 시약 공헌했다. 쓴
논문 : LW MM은 YT 주니어 노스캐롤라. 펩타이드 Synthetized 및 참가
주니어 : 실험의 디자인 인치

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    Hair Transplant Photos & Reviews

    1 / 17
    포토후기 이미지
    모프로의원
    Mopro Clinic

    It's been a year since the Hair Transplant surgery.I'm very satisfied because it's much closer than it was in the 6th month The director told me to do whatever hairstyle I want..I was happy that you did that! I got used to the full hairline, so I forgot about it before the surgery, but looking at the before photo for the first time in a long time, I'm glad I got the surgery I don't get stressed even if it's windy, and I like it because my face gets smaller I was worried that the occipital incision would also leave a chest, but maybe because the director sutured it so meticulously, he couldn't find it in the salon I'm very satisfied. I have to see the surgery for a year, so I think it's a good thing I did Hair Transplant as soon as possible.And most of all, I'm satisfied because I chose a surgical hospital well 

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    포토후기 이미지
    용닥터의원
    Yong Doctor Hair Transplant Surgery

    It's been 4 weeks since I got the Hair Transplant from Dr. Yong Kim Yongbin.^^In the 2nd week, it was very short like a weedI'm so proud of how I grew upI don't know if the dark ages startedIt's a bit more denseI really like the line^^Imagine that this line will be fullI feel good for no reasonI think I'm gaining confidence, tooIn the morning I wakeWhen I see my hair falling out of my pillowI'm a bit confusedWhen I went to see the progressDirector Kim Yongbin's surgery went really wellYou said that I'm wearing well, tooI believe thatI'm watching you comfortablyDr. YONG, I've been using hair loss shampoo and taking care of itI'm going to drink black bean milk, tooOf course, no smoking and no drinking ^^The bigger the surgery, the more reviewsI recommend you go to a lot of hospitalsI'm feeling it againDr. Kim Yongbin, thank you for your surgery^^

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    포토후기 이미지
    다나성형외과
    Dana Plastic Surgery

    HelloAt this age, I gave up saying that I'm going to have surgery to enjoy wealth... Still, I'm already writing a review of my 5th month after thinking about it for years, saying I can't give up on my hair. Looking back, I saw my acquaintance's great success here with my own eyes, so I was able to choose with confidence even though it was a long distance. Even though it was a massive hair transplant called 1,900 hair follicles, it was also the best choice to be able to finish it safely in a day thanks to a systematic team surgery system. In the dark days of the 1st or 2nd month after the surgery, the transplanted hair started to fall out and I felt empty for no reasonThere was a sense of impatience and anxiety as to why I didn't do it earlier, and in the third or fourth month, I saw a little bit of fine hairs and I was gradually relieved.And now, in its fifth month, we are realizing a distinctly different period of storm growth from last month. Now, the little hairs are quite thick and strong, so the stiffness and weight felt when you sweep the transplant area with your hands are completely different. As the M-shaped part and the front line of the scalp are gradually filled due to the sturdiness, a very natural silhouette is coming out just like the cool design you drew at first. In addition, despite the mass hair transplant, the scalp remains clean and healthy without inflammation or folliculitis, so you once again realize the Dana Plastic Surgery's skilled technology. When I meet people around me for the first time in a long time, everyone looks at my hair, and they say that the effect of hair loss medicine works amazingly well, and they ask me why I'm so young these days, but when they say they have a Hair Transplant, they are surprised and busy asking for hospital information. In my 50s, I was hurt by the fact that I looked older than my age, and I gave up getting dressed up, but these days, I feel like I'm 10 years younger, so I pay more attention to my clothes when I go out and I'm immersed in the fun of looking in the mirror every morning. These days, the Hair Transplant feels the word that time compensates honestly, and he feels so much satisfaction that his pain from Yeosu to Seoul is overshadowed. If there are people in their mid-50s or older who want to give up their lingering feelings about what surgery is at this age, I really want to tell you to never hesitate to go straight. I also managed it with medicine for a while, but I decided that I had reached the limit to get better, so I came to the surgery. If I kept thinking about it and delayed it further, I would regret it every time I looked in the mirror for the rest of my life. ^^After the surgery, I feel like I have gained a great strength to stand on a new starting line of my life and live the rest of my life more confidently.The concern is only to delay the operation, so I strongly recommend you to receive counseling first, and I will come to report in a richer and denser form in the next six months. I hope you all make the best choice. Way to go! ^^

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    모바른의원
    MOBARUN HAIR SURGERY

    I'm a man who had a hair transplant a year ago at Morbarn Clinic.My forehead is naturally wide, and I think my hair is going onWhile visiting the hospital, I visited Han Sang-bo, the director I met on TV and various media, and received an Hair Transplant. The counselors and the nurses were very kind and they checked very carefully. It's just been a year now, and I'm satisfied with the results and the birth rate is really good even though my hair is malignant. Thank you!

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    한나이브모발이식센터
    Hannaeve plastic surgery

    I leave a review immediately after the surgery. The M shape was really deep. The straight hairline is my dream... I asked for a straight line when I was in counseling. It's the final design date, but it's slightly curved, so it's natural He caught me. Maybe it's because it's a nasolabial cut, and it almost hurts, and I shaved my head, but after about 2 weeks \n, it's covered I think I'll get better after growing my hair I've been thinking about getting a hair transplant for years, but it's great to finally do it The head of the Hannaeve plastic surgery garden helped me and the head of the anesthesiology department only did the anesthesia. I'll continue to go to the hospital to get care of myself Thank you. 

    조회수 113
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    모원성형외과의원
    MO.1 plastic surgery

    When I look around, I feel like I'm getting older I think it's when I'm over 40. Even at the same age, the difference is clearly evident depending on the management? I don't think it's bad, but if you talk about your appearance one by one You can't just laugh now? Is it just me; From the 30s, the thickness of your hair is also an important score for your appearance. I heard that my hair part looks empty. I always have a hard time making volume One day..I don't know if I'm already like this, but I'm scared of surgery, so I looked into the procedure first I can cover my concerns with scalp tattoos Many people said that it's better to do Hair Transplant together if you want volume. I went to counseling with the thought of making it clear I hesitated because there was no place I liked. When I got counseling from Director Jeong Jae-hong, I heard about microscopic hair transplantation I thought I could get it with less anxiety I've decided on an operation. (I'm relieved that there are many cases of parting my hair.)You explained it in detail, but what I remember is It goes well with my hair part, which I'm worried about They use a microscope that can be magnified up to 20 times and transplant it It's safe!!  I think that's about it LOL I'm telling you to do anything when you decide, but I can't make a reservation right away because of my schedule Today! I planted hairline and got scalp tattoos. I always part my hair on one side (On the other hand, isn't it very awkward and uncomfortable if you part your hair? Is it just me?) The point where you can see the empty scalp better!!  What I felt right after the surgery was a scalp tattoo I'm relieved that it's controlled? I heard that it's not the end of the first episode It's gonna be really natural later on.. I'm looking forward to it Since the part I received is near the hairline If you plant it wrong, all the hair that was there will fall out I was really worried until the end when I heard people teasing me During my scalp tattoo and surgery, I was worried Other than feeling a little red and tingling after the surgeryIt wasn't uncomfortable, and what I felt right after the surgery was that I should pay attention to And I was taking care of everything to make sure there were any inconveniences For those who are worried about surgery, there are enough cases of transplantation, counseling well, transparent management of parameters and hair follicle water, and how the surgery is done I hope you check it out I decided after considering everything, and I think I'm in a good condition today It's still the day, so I'll have to wait and see, but I don't have much resistance even if I look in the mirror right now I'll recover well and come back to share how I feel next time

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    뉴헤어모발성형외과의원
    NEWHAiR

     <Before surgery> <After surgery>This is the review of the 7th day after Hair Transplant surgery.I was worried that the upper hair loss was getting worse, so I decided on Hair Transplant. On the day of the surgery, I had a little pain and swelling on my forehead, but it wasn't as bad as I thought, and I followed the precautions I was guided by taking the prescribed medicine.For two to three days after surgery, I was careful not to touch the transplant site, and I was also careful not to press my head when sleeping. I'm currently on day 7 and most of the swelling has subsided and there's almost no pain. There are still scabs left, but we are carefully managing them because it is an important time for birth.It's still too early to judge the results, but so far, I'm recovering without much inconvenience and I'm satisfied.I'll watch the progress and leave a review in my spare time.

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    헤어로의원 대구점
    HAIRO HAIR TRANSPLANT CENTER Daegu

    There are scalp and follicles as well as hair loss, so if you don't have good progress after surgeryI was worried about what to do, but thankfully, the hair clinic director was meticulous about the progressThanks to your meticulous scalp treatment, I've grown out my hair for a yearIt grew well and was filled up beautifully.I was waiting a year until I got surgery counseling, but after the dark agesMy hair grows fast, so I open my eyes even if I don't have to take care of it It grew up well on its own, so there was nothing to say about managing it.One thing that's unfortunate isWONCHAE's short hair was long, so I couldn't stand it when it was 2 weeks after I planted itIn the 2nd week, I shaved my hair slightly with a barricade on the top of the tip, but after a whileI'm a little disappointed because the stimulation went to the place where I planted it at that time.I think it would have been better if I had just endured it and waited for itIt's already been done by me, so I have no choice but to accept it and plan to schedule it later to reinforce itBut it's been a year or so. I don't feel uncomfortable in my daily life. It's just like my hairEven if I get older and plant more, I want to get it from the owner of the Daegu branchI was satisfied.

    조회수 124
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    헤어로의원 동탄점
    HAIRO HAIR TRANSPLANT CENTER Dongtan

    It's been a long year since I got my Hair Transplant at the hair clinic this time last year.Everyone calls it graduation around this time, so I think I'm graduating now, so I'm leaving a review like thisI think the management was not much different from what I saw in the DAEDAMO or what the hospital told me.I think I survived a year without much inconvenience doing what the hospital told meMy concern was that my bangs looked bare in the middle, but I think it's a good thing that my Hair Transplant covered this up.Thank you to the hair clinic staff who taught me how to take care of it in the middle ^^

    조회수 137
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    모우림의원
    Mowoolim Clinic

    Apgujeong reverse hair transplant is a review of Mo Woo-rim clinic before the operation He had a wide forehead and an M shapeI got counseling at the Mo Woo-rim clinic after my acquaintance's recommendation, and I got counseling from Han Ji-youngHe was kind in counseling and recommended by Director Lee Seung-ah, so I set the parameter to 1,700mo after consultation with the directorI'm scared and nervous, but I liked that both the staff and the director were kind I didn't feel any pain because of anesthesia on the day of surgery After that, the pain was okay because I took the medicine, but I had surgery with an incision, so it was quite painful because the incision came into contact with it when I slept, right????I thought I should plant more because human greed is endless, but first of all, I hope the transplant hair is well-established, so I hope it's maintained well

    조회수 137
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    모나라피부과의원
    MONARA dermatology clinic

    First of all, if I can tell you how I feel about the 4th month of M-shaped Hair Transplant... Phew~~~~~~ I'm glad it's coming up well.~~In fact, my hair fell out from the first month of the dark period. I know you're going to be in the dark, but... just in case,,,I saw a lot of reviews that weren't like that, and I was like, "Please slowly molt." I was quite surprised because it fell outBut I can't get distracted here, so I've been able to hold myself together, and the director was so good at holding me together, so I came up wellAnd as you can see from the picture of the 4th month, it's growing well as it's plantedThe thickness of the hair is still thin, but I'm relieved that the director convinced me that the thickness gets better and better over time. Now, I'm not going to forget about hair loss pills and I'm going to take care of it well!During the 4th month of the checkup, the doctor made sure to check the progress and grow your hair betterI got a good feeling because they even gave me nutritional injection care for my scalp/fleeceActually, it's a battle with time, so there's nothing special to manage, I'm trying not to get stressed by taking hair loss pills, eating well, and exercising hard.It was mentally difficult to manage in the beginning after receiving Hair Transplant, but I'm very fortunate to meet a good director. I will end today's review imagining how it will become denser and better in the next eight months or a year. I'll leave a review on the next episode!

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    모모의원 부산점
    Momo Clinic

    Hello, I'm leaving a final review of a year after transplanting.I've left a few reviews after surgery before, but it's annoyingI think it'd be better to share the final review after I forget about it because my hair grows well I'll leave it.I've had hair loss for a long time, and I've had scalp injections 10 years ago, and in between, I've had avodat It's not easy to eat after eating some, so I stopped and left it unattended, but decided to Hair Transplant last year.The hair loss got worse when I left it unattended.I live in Ulsan, but when I looked for it, there was no Ulsan hair loss hospital, so I looked into Busan. Looking at the reviews of the DAEDAMO, there were many hospitals in Hair Transplant, so I was consulted to Busan, and the consultation with Director Ko Sang-jin was the best, and the hospital was big, so I got a transplant here.I got it as a non-cutter, and I took a day off from transplant and worked, and it was good that my recovery was really fast.In the beginning, I had itchy things for a few days, so I was thinking about sleeping with plastic gloves on, but not for a long time. I think it was for a couple of daysThe dark ages came for about two months, and by the time I was six months old, my hair grew a lot.It's been a year now, and I heard that it usually takes about a year to complete your hair, but by my standards, it was almost completed after about 10 months.I'm going to upload a comparison shot between the picture I posted last time and the picture of my first year.Grow up, everyone.

    조회수 177
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    인천 맘모스헤어라인의원
    Incheon Mammoth Hair Restoration Center

    - Hair loss type: M-shape- Surgery period: 4 months- Number of follicles: 1000 follicles- Cost of Hair Transplant: KRW 8 million- Collection Method: Non-cuttings- Surgical method: doctor's slit, doctor's transplant- Details of progressAfter the dark ages, almost all of the transplanted hair has fallen out and is gradually coming up.More than 90% of the senses at the collection site returned, and scars and pain recovered to the extent that they did not interfere with daily life.I am taking hair loss medicine steadily without missing a day.It's the end of the dark period, with no dramatic changes yet, but I'm just waiting for the fluff to thicken. I hope other people who are in the dark age will cheer up and endure it.

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    모우다의원
    MOUDA CLINIC

    I chose it because I believed in the beauty and meticulousness of the female director of the MOUDA CLINIC.The consultation was also conducted only with the director, and he told me his questions clearly, so I decided right away.It's been three weeksExcept for not being able to cool down shampoo, I've been doing well so that I don't feel too sick, itchy, or uncomfortable.I'm relieved to hear that it went well.In particular, I wanted to fill only the empty spots naturally, but I like it even more because it transplanted so that I can save my baby hair.In the second week, I also sprayed medicine on the occipital region and received laser treatment.I'm really looking forward to the future.My scalp is still a little red, but it'll get better over time.I'm not really worried. 

    조회수 160
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    부산 맘모스헤어라인의원
    Mammoth Hair Restoration Center Busan

    It's already been nine months since I started Hair Transplant. I think time has gone by really quickly.For postoperative management, I have been taking and managing the medicine steadily as the hospital guided me. I was worried at the beginning, but as time went by, I saw a change, and now I'm quite satisfied.As expected, I think it was a good choice to choose Mammoth Hair Restoration Center. Whenever I come to see the progress, I am always grateful for checking the condition meticulously and responding kindly.Although it is still satisfactory, I am looking forward to the future as the normal Hair Transplant can continue to change from a year to a year and a half.I hope my experience will be a little helpful to those who are considering surgery. Thank you to the Mammoth Hair Restoration Center medical staff for their kind management and care. 

    조회수 176
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    움찬의원
    WOOMCHAN Hair Transplant Clinic

    I visited after thinking about the Hair Transplant, and I was relieved that you were very kind to proceed with the consultation. The director meticulously conducted the entire process from counseling to surgery, and explained in detail the questions in the middle. You took care of it carefully so that you could receive it comfortably on the day of surgery, and the results are satisfactory. I would like to recommend it to those who are concerned about Hair Transplant. 

    조회수 128
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    연세모벨르의원 인천점
    Yonsei Mobelle Clinic - Incheon Branch

    I transplanted 3,000 hairs with a non-excisional Hair Transplant.It's the 2nd week so farI searched a lot about this place and chose a hospitalDirector, the consulting teacher, in detail to make it easier to understand Thank you for letting me knowI was thinking about getting my forehead done, but I was going to get surgery on my stomach I heard it's better to get a forehead treatment after a transplant Transplantation first  I did. I'm very interested in doing facial procedures. ^^I did partial anesthesia. The surgery was relatively easy As the hospital told me, I took good care of it after the surgeryI was worried that it would work because my hair was thin and thinIt's been 2 weeks, so I don't know yet, but I didn't have hair in the beginning I think the director did a good job These hairsI'm looking forward to it when I think it's growing fast.in the next four months  I'll upload another picture

    조회수 173
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    연세모벨르의원 종로본점
    The Jongno Headquarters of the Yonsei Mobel House

    Since a few years ago, I've noticed that the M-shaped part is gradually rising and the hairline is retreating, but looking at the recent photos, I think it's progressed more than I thought, so I got a Hair Transplant consultation.As a result of hospital treatment, hairline hair loss is currently in progress, and in particular, the density of both M-shaped areas and frontal parts has decreased. I've been told that the top of my head is still relatively good, but I also need to consider the possibility of future progression...After checking my occipital condition during consultation, I received an opinion that if I transplant about 3,000 hairs in a non-cut manner, it can complement the current hairline and naturally correct the M-shaped area. Rather than creating an unreasonably low hairline, I was recommended a natural design suitable for my age and face shape, and I overall agreed and decided to operate.The most worrisome part before surgery was the birth rate and the progression of hair loss in the future, and I was told that existing hair care was important while taking medication after transplantation.In the end, I decided to proceed with a non-cutaneous 3,000-mo transplant, and I had a medical treatment for 3 months from the 1st week and 6 months today, and I also told the director, but now it is much easier to make a style.I'm also considering medication. In the future, I will leave a review with a picture of the progress.I hope it will be a reference for those of you who are in a similar age and are worried about hairline or M shape, and I hope everyone will be successful.

    조회수 278
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    압구정 맘모스헤어라인의원
    Mammoth Hair Restoration Center, Apgujeong

    Hello.This is the review of the 4th month of Hair Transplant.After the operation, there was no significant disruption to life. It is said that the dark period is until the fourth month after surgery. Nevertheless, as in the picture above, a lot of transplant hair is being filled and lengthened. Until now, I like tennis, so I exercise more than four times a week, and I have not experienced much discomfort and my hair has been cracked after exercising.Regarding medication, I take one pill a day of pinasteride (propecia) medication. I'm glad there are no side effects.I came to the hospital to check my progress when I was 4 months old.I received the procedure from Nam Da-woo, but I went to the Incheon branch and received a progress check from Seok Ji-woong, director of Apgujeong. In this part, the hospital gave me a choice, but I chose to visit Apgujeong for my convenience. I received it well because you took care of my scalp as soon as I went. I would like to take this opportunity to thank the teachers for their kind and careful management.After taking care of the scalp, he consulted me and heard that the transplant hair was growing well, and he said that it had grown to about the size of the stomach picture because it was in the dark age, and that it would be twice as large as the transplant in the future. In fact, I was satisfied with the current progress, so I would be even more grateful if I grew up here.

    조회수 293
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    모더함의원 모발이식센터
    Moderhamm Clinic — Hair Transplant Center

    ✔ Surgical type (Hair Transplant or hairline correction): Hair Transplant✔ Name of hospital (no initials): Apgujeong Mo + Theham Clinic✔ Hair loss type: Hairline✔ Elapsed period: Day 2 of surgery (next day)✔ Number of wool (clothes): 2648 wool✔ Cost of Hair Transplant: KRW 7 million✔ Collection method: Non-cut fine hydration✔ Transplantation method and doctor/nurse transplantation: Planting machine & doctor transplantationa review of the procedure on the day of surgeryThe operation took about an hour and a half to two hours to collect hair follicles by non-excision, and it took about three hours to plant in earnest, which took a total of nearly five hours. It was a long time, but the hospital atmosphere was comfortable, so I passed it less than I thought.1. Consultation and atmosphere with the directorJeong Han-byul, the chief director of my surgery, was so gentle and kind. The tone of the director's voice itself is so calm that my nervous and nervous mind before surgery calms down and I feel comfortable.2. the degree of partial anesthesiaOriginally, I applied for sleep anesthesia, but right before the operation, I was so hungry that I thought I couldn't do it, so I said I would cancel it on a whim. Even though you might have been embarrassed, I was grateful that the hospital accepted me pleasantly and quickly switched to partial anesthesia.To be honest, the partial anesthetic injection that I was most worried about is painful. But it wasn't unbearable at all, it felt like I was getting a tattoo of my eyebrows that hurt a little bit, so I was able to hold it in. (I'm also good at putting up with pain.)3. Careful care during surgery and small talk with the doctorIn the middle of the operation, the doctor will continue to check whether the anesthesia is maintained well. If you feel pain even in a very slight way while proceeding, you immediately added an anesthetic, so the surgery itself was comfortable without any pain.I couldn't sleep at all because I didn't have sleep anesthesia, so I kept talking to the director throughout the surgery. The director took my stormy chat and small talk very well, maybe because he has a tremendous ENFP tendency. Thanks to this, I had a pleasant conversation without any time to be bored, and the surgery was already over. The director and nurses were responsible for the transplant until the end, so I was more trusted.----Today, the day after the surgery, I looked in the mirror and saw a filled hairline, so I'm already amazed and satisfied. I think I was really good at choosing Senator Moderna to the point where I wondered why I was worried and scared for so long.It's only the second day, so we need to pay full attention to the birth management so that the transplanted hair can survive well in the future, but I believe there will be good results because the director planted it so meticulously.The cost was not low, but I had a lot of worries and hesitated because of shaved head or pain, but I think I got the first step well thanks to the hospital's careful care and the doctor's expertise. If anyone is thinking about Hair Transplant because of their hairline, I hope my review will be a little courageous. I hope you all have a lot of success!<Before surgery>

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    모든모의원
    Modeunmo Clinic

    Hello, I got a Hair Transplant for an incision about 10 years ago.I feel like I'm losing density againWe had a re-movement ceremony ^^I was much more satisfied than before because I didn't have any scarsI've been through the dark ages before, but I still can't get used to itI'll think it's just the beginning, and I'll work harder to show you good results

    조회수 395
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    노블라인의원
    The Nobleline Center for Alopecia Care

     It's been exactly 100 days since I got surgery from Baekhyun-wook at the The Nobleline Center for Alopecia Care. When I posted it on the 30th, the dark age started, but I was a little worried because I didn't get much better yetHe said it looks very typical in the 3rd month, so he told me to wait a little longer and my hair will grow noticeably.I don't think it's much to say, but I'm relieved that the director who performed the surgery himself said this.After hearing that, I think my head is coming up little by little.As expected, when you are nervous and curious, it is best to ask the hospital instead of suffering alone.If the director tells you directly like a The Nobleline Center for Alopecia Care, it's better from the patient's point of view.I think this is also a little tip if it's a tip when choosing a hospital.The weather has gotten hotter, but I think I will do my surgery quickly and spend the summer without suffering.Everyone, be careful of the heat, and as the director said, if your head comes up to the point where you can see it in a month, I will leave a happy review.

    조회수 444
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    인천 마이모 모발이식의원
    MYMO HAIR TRANSPLANT CENTER Incheon

     After removing the scab.There is still a redness in the transplanted part.And the back of the head collected from the hair is also very slightly painful and sometimes itchy. It was said to be a normal thing in the recovery phase.From now on, the transplanted hair will fall out for about a month, so I'll take good care of it.

    조회수 436
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    모앤블레스모발이식
    Mo&Bless Hair Clinic

    I've been taking hair loss pills for about 10 yearsI thought it'd be better to fill my hair when I was youngI'm going to have a Hair Transplant.There's a limit to hair loss medicineI filled in the gapsThere's definitely an advantage to hair transplantsIt's not fully grown yetI can see that it's getting fullerIt will be full after half a yearI hope time goes by soon

    조회수 506
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    부산 그로우의원
    Busan Grow House

    Because of the M-shaped hair lossI was under a lot of stressI came across Congressman Grew on the InternetThe director said that only one person a day is going to get surgeryYour confidence in your words has skyrocketed, so right after consultation with the hospitalI've decided to do 2500 m.o. by nasal incisionAfter the doctor explained in detail, please proceed with the surgery I spent nearly five hours responding to the friendly response of the staffI had a very comfortable surgery The anesthetic was stinging, but the surgery wasn't uncomfortable at allAs the day or two passed, the sense of hair that I was eatingHe came back about a week laterNow that it's been 2 weeks, the tickets are almost goneI hope you'll be filled with rich hair after this dark periodI'm looking forward to itFor those who are hesitant like me, please consider surgery after consultation. It was a very satisfying experience 

    조회수 477
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    모엠의원
    MOEM Clinic

    [On the day of counseling][On the day of surgery][Two weeks later]The picture is only until the second week, but over time, we're in the fourth week of non-cut surgery.From the first consultation, I think I made a reservation comfortably thanks to the kind counseling staff and the pleasant director.I think MOEM Clinic is a big advantage of the delicacy of taking care of snacks and porridge on the day of surgery.In fact, I made an appointment expecting 3700 hats, but after the surgery, I saw that they were wearing 3800 hatsThank you again for taking this opportunityI'm writing this 8 days after taking a picture in 2 weeks, but now my hair is growing more than that picture, and I've run out of scabs, so I'm living my daily life very comfortably. I'm so happy that it came out so naturally that people around me wouldn't know if I didn't say it hahaIf you are still thinking about it, I recommend you to consult Jeon Ji-hoon, the head of MOEM Clinic!I hope you feel your positive energy and have a good result!

    조회수 518
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    포헤어 비절개모발이식센터
    FORHAIR Hair Transplant Korea

    It's the 4th month's review of the dark period after undergoing Hair Transplant for hair loss on the top of the head.Before surgery, even though it doesn't seem to be visible from the front, you can see it under the elevator mirror, CCTV footage, or bright lights It was really stressful.Especially, when I took pictures, the top of my head looked empty, so I was paying more attention than I thought, and I'm preparing to get married We need to resolve it before it's too late I decided to do Hair Transplant with that in mind.The top of the head has relatively fewer reviews than the M shape, so it wasn't easy to choose a hospital, but I looked for hospitals with more reviews of the top of the head There are many reviews from over a year ago While looking for it, there were many reviews of the top of the head in Apgujeong's forehair, and the results were good, so I finally decided and proceeded with a non-cut method in the forehair.To be honest, it was more difficult than right after the surgery in the first to third months. As the hair that I planted started to fall out, I felt like my original hair looked weakHold it up I ended up looking at the mirror more. Especially, the top of the head is not visible every day, but if you take a picture of it, it looks more hollow than you think I got impatient for no reason.But now that it's been 4 months, the atmosphere seems to be changing for sure.Of course, it's far from the finished result and it's not very dense yet, but it feels like you can see your hair first rather than your scalp It's changing little by little. If you look closely, you can see short and thin hair and it looks empty I think the range has also decreased compared to before.If you look at the picture, you can see the difference better, but before surgery, the center of the top of the head looked hollow, but now the hair is between the empty spacesAs you come up It feels like the boundaries have become blurred. It's still thin, so it depends on the lighting, but compared to the dark age, it's definitely in the recovery sectionI can feel that you came in.When I washed my hair, I didn't feel like I could hold it in my hands before, but these days, I feel like short hair gets stuck in my hands, and even when I dry my hair, the volume of the top of my head seems to be reviving little by little. It's a small change, but I feel it more than I thought, maybe because I see my hair every day.Also, I'm constantly receiving postoperative care from my forehair, but they don't just end up with surgery, but they also keep taking care of the progress and care of me There wasn't much difficulty either.Surgery results are important, but this follow-up part seems to be one of the reasons for high satisfaction.The director said that the top of the head comes up from at least 6 months later, and you usually have to see it for about a year As of the 4th month I think the darkest period, which was the most anxious, has passed and I think this is the real beginning.There's still time until the final result, but if you compare the pictures before and now, there's definitely a change I'm looking forward to the 6th, 8th, and 10th months more. In the next review, I'll come back with a more filled version.

    조회수 634
    댓글 1
    포토후기 이미지
    모재성모발이식센터
    Mo Jaesung Plastic Surgery & Hair Transplant Center

    I took a picture at home before I went for my first year inspection tomorrow. I'm not sure what the exact birth rate is, and I'm going to ask the director tomorrow. Personally, I think it's hard to say that it's improved dramatically like everyone else. My first surgery was so unsatisfactory, so I wonder if this is the limit of reoperation Especially when viewed from a bright place, there is still a lack of density. Still, the satisfaction level is not low enough to think about reoperation again. If you style it well, it just looks like you lack a lot of hair. Compared to before surgery, the hairline and overall impression feel clear. It's hard to say that it's completely satisfactory, but I'm still accepting it to some extent. From now on, I'm going to take care of my medicine or scalp steadily and pay attention to maintenance.

    조회수 727
    댓글 1
    포토후기 이미지
    모플러스성형외과
    MoPlus Plastic Surgery

    I'm still taking my medicine. (I'm cutting minoxidil in half)The hair that fell out in the dark age is now very roughThe hair that didn't come out grew outSo the length is a bit differentI turned it into a positive moment and focused on taking care of myself without getting stressed as much as possibleI went to the hospital and got a shot todayI took a picture after getting a shotEven if I put my hair back, it looks natural, so I don't cover it upIf you grow up at this pace, I think I can graduate like Morplus plastic surgery seniors

    조회수 599
    댓글 3
    포토후기 이미지
    헤어로의원 전주점
    HAIRO HAIR TRANSPLANT CENTER Jeonju

    After 9 months, I went on an overseas business trip I couldn't use it until two months later I've been writing reviews for 2 weeks "You planted it well, but I'm slow to recover." "I'm worried that I won't be able to grow it out well, so I'm trying to take care of it more." And I really put a lot of effort into taking care of it My wife bought me a lot of nutritional supplements He takes care of me every evening. He takes care of me when I go to work I've been receiving a lot, and I've been here for 9 monthsThe dark age came around a month ago, so the hair that I planted fell out I've been taking care of my skin like before As healthier hair grows, after 9 months, my hair condition As you can see in the picture, Director Na Haewon I think we've grown as well as you've plantedAfter the dark ages, when my hair grew new When you meet someone, you gain a lot of confidence and life I think it's divided into chapters before and after receiving Hair Transplant.I'm so happy these days, and my family, who see me like that I'm having a happier day because you like itI'm trying to take care of myself even before I go to see it after a yearIf you're worried about hair loss, don't get stressed Am I losing hair? When you're in doubt, go to the hospital and get treatment Take itIf you didn't do that because I put it off and put it off That's why I wrote it down I'll grow it out again. Fighting

    조회수 573
    댓글 4
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    연세모벨르의원 대구점
    Yonsei Mobelle Clinic - Daegu Branch

    Actually, I had a Hair Transplant by incision about 10 years ago. I was satisfied at the time, but as time passed, hair loss progressed little by little, In particular, the density of the part in the middle looked very empty. It bothers me every time I look in the mirror, so I ended up looking for reoperation.There were only two things I saw importantly while looking for a reoperation hospital.The first is a place with a lot of experience in non-cutaneous Hair Transplant. To be honest, I remember having a hard time during the first incision This time, I thought I should definitely make it non-cut.The second is where the doctor conducts the surgery himself from the beginning to the end. I went to counseling, and the actual transplant was done by a doctor There are places where other people host. It took me a while. Aside from the cost, it's a reoperation, so from beginning to end I wanted a place where the director would do it himself.I got counseling from various places and got counseling from Yonsei Mobel You explained it in great detail. Especially in the case of reoperation like me, the part that was transplanted before became hard They said that if you use only a hair implanter, you can get a popping phenomenon where your hair sticks out.That's why I was recommended to use the slit and the hair implanter together to increase the birth rate. I'm not just sticking to one method It was reliable that we proceeded according to the current scalp condition.Most of all, the slit process was also carried out by the doctor himself. These seem to have been the biggest reasons for deciding on a hospital.It hasn't been a long time since the surgery, but the progress so far is satisfactory. The transplant area is cleaner than I thought, The actual surgery process was not much different from the explanation I heard during the consultation.Of course, we'll know the final result after a few more months I have an expectation that it will settle down well with the current feeling.

    조회수 482
    댓글 3
    포토후기 이미지
    모아트의원
    moart clinic

    It's a review of 240 days.Certainly, as the period has passed, the hair has grown a lot, so there is no big burden.My scalp doesn't hurt at allThere are naturally variations because they fall out and grow back by hair, but they are basically dense and satisfactory.

    조회수 693
    댓글 4
    포토후기 이미지
    JP성형외과
    JP Hair Transplant Clinic

    I planned a Hair Transplant but it didn't work out.I recently went back to consultation and had Hair Transplant two weeks ago.But this time, we got an eyebrow transplant consultation and we did the transplant togetherAs shown in the picture, the hair implanted in the transplant area is well positionedMost of the redness and scabs are goneAs you can see from the pictures before the surgeryIt didn't grow at all in the empty areaSo I got a small 170-mo transplantI think it looks much more natural, so I like it. What do you think…My forehead was a bit swollen in the beginning, but after a week, I recovered naturallyI'm comfortable with my daily lifeThe occipital collection area doesn't show as much as you think because your hair growsIt's definitely a good feeling to cut the nasal sectionIf it's dark, your hair will fall outI'm a little worried, but I hope you sleep like this

    조회수 740
    댓글 8
    포토후기 이미지
    모다올의원
    Modaol Hair Transplant

    Hello, I'm finally leaving a review after the surgery.I was stressed out because of the split bangs, but I wanted to finish it this year, so I sold my feet and even had surgery.1. Hospital Selection CriteriaThe most important thing I saw was the director's skills and case experience. I was lucky enough to know and recommend Yang Yoo-gun from one of my acquaintances, and I made a consultation reservation right away after hearing that he opened a separate business. I could trust him because he had such a brilliant career when he was a large hospital.2. Consultation and DesignYou really hold the line carefully during consultation. It's not always lowered, but you design it with the most natural golden ratio considering my face shape and eyebrow position, and I was sure of it here, so I fixed the date right away.3. Parameters and costsQuote: 2900 Mo + @ (The director filled in more tightly with services that lacked density.)Cost: mid 7 million won4. Day of surgery~ Current reviewThere was almost no pain except for a little stiff during anesthesia. Maybe because he was from a large hospital, the director's hand skills were really good. I felt you transplant it at a very high speed without disturbing the direction or angle. Looking at the slit filled with 2,900 mo and plus alpha, I feel at ease.The mid-7 million won is not a small amount of money, but I wonder why I delayed it when I looked in the mirror. If you're all worried, I recommend you to get counseling first. If you have any questions, please leave a comment and I will share it with you. I hope you all have a lot of success!

    조회수 661
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    부산 리즈모
    Rizmo Clinic - Busan Branch

      Surgical type: Hairline correction- Name of hospital (no initials): Rizmo Clinic, Busan, clinic- Hair loss type: Hairline partial shaved head- Surgery duration: 2 weeks- Number of hairs: 2200 moles- Collection Method: a non-cutter Hair Transplant- Methods of transplantation and doctor/nurse transplantation: a doctor's slit / doctor's transplantThe clinic in Rizmo Clinic, Busan, lowered the hairline and filled the M-shaped hairline.There are only a few Hair Transplant hospitals in the Busan area, but I heard that follow-up care is more important in Hair Transplant, so I decided to go to the nearest place to my house. I've been consulted at other hospitals, but the prices vary widely from hospital to hospital, so I couldn't figure out what price range is right However, at the Rizmo Clinic clinic, the price was reasonable, and first of all, the head of the department and the head of the department Kim Doo-sol matched the design I wanted well, so I set the date for the surgery as soon as we consulted lolIf you look at my hairline before the surgery, I saw a horizontal M shape on my forehead when I took a picture on a windy day because my hair was thin + less dense + fine hair. ㅠ So I focused on filling in the M shape as much as possible, so I lowered the height of my forehead a little It's my 2nd week, and it came out well and I'm very satisfied with the line. ㅠ I'm going to go to the hospital in the 8th month after the surgery, and I'm going to take biotin and take good care of it until then! We'll be back with a review after 8 months Haha 

    조회수 603
    댓글 3
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    광주 압구정모비앙의원
    apgujeong mobien

    Mobien came to see people around him after the procedure.The person who got the procedure from Choi Hyun-yong looked so good that I also got a transplant from Choi Hyun-yong. Having a hard time with sleep anesthesia, I was very nervous about having to do it twice, but the nurse and director next to me kept talking to me and making me comfortable, so I was able to relax and get a transplant comfortably. The director set the transplant line so naturally that it looks like my original line, so I'm so happy that I don't care about my daily life. I'm looking forward to the future because I've heard that the hairline looks much better because it's alive.  

    조회수 519
    댓글 2
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    모디헤어플란트의원
    Modi hariplant

    Hello, I had symptoms of hair loss since 3-4 years ago, and since then, I have been taking blood steadily until now, when I received the transplant   The reason I got the transplant was because my forehead was so wide that I had to fix it with a fixer, but I was worried that the more I used the fixer, the worse the hair loss would be And even if I fix it with a fixer, I can see the empty inside if I look closely I hated rainy days when my hair was ruined and windy days I couldn't even run around as much as I wanted Buses and subways that I haven't been able to run are passing by... I admit. I'm very self-conscious He's always conscious of other people's eyes and acts Hair loss was a huge stress, shame, and weakness for me Even if I have a girl I'm dating, I'm worried that I'm going to lose my hair It was this serious, so I didn't go outside unless I set my hairI was reluctant to go out even on a bad day Then, I decided to Hair Transplant because I thought I couldn't live my life in such a passive manner until long, so I looked around every famous place on the counseling tour.The price range in the Gangnam area is really highBut just as cheap doesn't mean everything is good, I decided to get a transplant from Modi after seeing your doctor's consultationI got it from Yoo Hwa-jung, and she explained it in a gentle way, so we were able to be calm togetherAnd he also pointed out the details I missed once in a while and proceeded with the designI also liked that part because I was told that I could sit down and get a transplantI don't think he'd have any back left, considering he'd been lying on his stomach all the time I'm nine months into the transplantI've improved my hair so much that I don't even know if they're the same personBut since this soggy hair loss is still going on, I'm taking the pinnacleNow my hair is long and natural, so I haven't used hair fix for a long time, and I go around confidently no matter the weather

    조회수 665
    댓글 4
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    모모의원 수원점
    MOMO's Suwon branch

    Hello~ As expected, transplantation is the answer. I'm also experiencing the results over time after transplanting and I'm directly experiencing the words. I've been getting counseling because I wanted to get a Hair Transplant for a while, but I delayed it because I couldn't find time and hesitated, and I finally got a transplant last year, and the result is amazing.The deep m-shape disappeared. I think I'm so free to do my hairstyle I wanted to grow out my hair again. Sports hair? I cut my hair close to a half-length hair Overall, it's growing again. When my hair grows completely, I'm going to try something I couldn't do before because of the m shapeWhen I was looking for surgery, I was consulted at a hospital in Seoul, and when I saw the establishment of Momo Suwon branch, I found out that I had surgery, and I highly recommend Director Moon Hyo-seop.I looked up the reviews of the past and asked the hospital, but the director had more than 20 years of Hair Transplant experience and he was a complete veteran with more than 5,000 surgeries. I think the most important thing in Hair Transplant is the doctor's career and skill.I had a common m shape, but I heard that the director was a person who did a lot of difficult surgeries, but the class definitely feels different.Suwon people who are looking at my reviews, don't go to Seoul and the Suwon branch in MOMO HAIR TRANSPLANT that I operated on is good.The director's career is clear, and I believe MOMO HAIR TRANSPLANT is a famous hospital in Seoul.I'm 10 months old, but I think the results are all out. I don't know if I'll leave a review next timeEveryone, finish the "m" shape and take over [Laughing out loud]

    조회수 706
    댓글 3
    포토후기 이미지
    헤어로의원 부산점
    HAIRO HAIR TRANSPLANT CENTER Busan

    as a result of poor hair loss managementMy hair that only fell out on my forehead... It's more than my hair getting widerIt's starting to go up to the top of my headI think I'll have to wear a wig if it gets worseI went to some consultations in Seomyeon, where there are a lot of Hair Loss Hospital.I heard that all the places I went to have a lot of parameters to plantIf you have to plant a lot, I think someone with a long career will do wellI got a Hair Transplant from HAIRO HAIR TRANSPLANT CENTER in Busan.I shaved my headThe surgery took a long time, but they kept checking the inconvenienceI remember having a comfortable surgeryI checked the progress, and so far, I've heard that he's in good conditionWhen I look at the line and hair density in the mirror, it looks okayI feel like I got it from a skilled directorI received prescriptions and explanations on how to take care of themI need to take care of it as I've been taught

    조회수 928
    댓글 7
    포토후기 이미지
    글로웰의원
    GLOWELL

    I'm 6 months old after receiving a transplant with 3,000 non-cutaneous hairs. If you look at the picture that I just finished the design before the surgery, you'll know The forehead line was also messy and unbalanced, so I didn't want to see it. So during the consultation, I asked the hair stylist to correct my hair line I said I wanted to keep my bangs cool You made the line look natural according to my face proportion During the dark ages, my hair fell out quite a bit, so I had a hard time It grew amazingly from the next month It's good enough to look at it now. It's only been 6 months, so my hair isn't 100% grown I heard that it needs to be more dense Honestly, I'm satisfied with how it is right now It was done through a nasal incision, and the place where the back of the head was collected was recovered quickly I didn't have much inconvenience in my daily life. Above all, as the hairline becomes neat, the impression itself seems to have improved. I'll come back with a review later when it's been a year and it's fuller! 

    조회수 843
    댓글 4
    포토후기 이미지
    모모성형외과의원
    MOMO HAIR TRANSPLANT

    Hello, I'm going to write the last review after the transplantI left a few reviews after getting the transplant, but I feel strange because the results are completely out and I leave themI saw the results of a senior who recommended Hair Transplant to me, and I saw a lot of other people's reviews through DAEDAMO.I feel new after getting such good results.I lived as an M and started taking medicine to protect my remaining hair, and with the company's senior recommendation and bragging I was introduced to the hospital and had surgery last year while taking summer vacationThere are many Hair Transplant hospitals in Gangnam, but Momo Plastic Surgery is the hospital that has been verified by seniors.I didn't go anywhere else, and I got counseling right here and even had surgery.There is a lot of information in the DAEDAMO, so everyone is quick, but let me introduce a little bit of the process I went through.First of all, it was an M-shape, and I got a 2,500-mo estimate, and I had surgery, but both incisions and non-incisions were possible After thinking about it, I chose an incision to save a little money, and because it was an incision, there was no shaved head on the back, so it was better in this area because it didn't even show the back of the hair after surgeryAfter 2 weeks, I started removing the thread and getting my fingerprint shamp done, but when I washed my hair for 2 weeks, I felt a little uncomfortable and bothered a lot.The dark age is an essential process that most people go through when they Hair Transplant, but when it comes down, it's a time where I feel bittersweet and worried.It was a time when I waited, watching all the hair that had been transplanted and planted so heavily disappeared at some point and became a mountain of Mindung again.The dark age was maintained for about three months.And around the halfway point, the heads began to grow again in the empty area, and from then on, the heads came up in abundance like running without hesitation, which is really touching.I personally felt the surprise of medical technology.When I think about it when I was young, I remember people living bald or wearing lame wigs, but now I'm turning my hair back, which was gone due to Hair Transplant.I got the hair transplant cost well, so I had surgery, and the result was very satisfactory. Thank you for the MOMO HAIR TRANSPLANT in many ways.I hope you all get good results with your Hair Transplant.

    조회수 1,012
    댓글 5
    포토후기 이미지
    모모의원 대구점
    Momo Clinic

    Hello, I'm keeping a record of the transplant.Actually, I didn't think I would be the Hair Transplant right away.I've been in the M shape for a while, and my wife has been telling me that the top of my head seems to be losing some weightI didn't mean to get my Hair Transplant straight away, but maybe it's because I saw it on my phone regarding hair loss and Hair Transplant...The algorithm brought me content related to Hair Transplant.As I was forced to watch it, I was curious and wanted to find out how much it cost, so I took some counseling as an experience, and some places were really expensive and told to operate right away, and consultations varied slightly from hospital to hospitalSome places are good to have surgery, but you said it was up to me to make the decision, and it was good because you explained the overall picture before and after the surgery and the expected hair loss progress. When I listened to the explanation and looked at the pictures of other people's surgeries, I didn't want to have surgery right away, but I couldn't think of Hair Transplant in my head.I'm not the type of person who decides something so quickly in my life, but I keep thinking about it and recommending my wife to have surgery, so I decided to get surgery by Kang Dong-woo, who had good counseling and cost well, and I completed 3,500-mo surgery. 3,000 M-shaped and 500-shaped transplants were received on the top of the head.When I first saw the contents related to Director Kang Dong-woo, I felt something gentle and likeable, but I thought positively when I received actual counseling. Above all, as mentioned above, I was impressed by your explanation from my point of view and comprehensive counseling such as what will happen in the future.I operated on the M shape and the top of my head at once, and I was prescribed medicine and started taking it.In my standards, I finished the surgery unexpectedly, but I'm looking forward to a good result because I had the surgery.I wonder what other people think.

    조회수 1,003
    댓글 6
    포토후기 이미지
    모제림성형외과의원
    MOJELIM Hair Transplant

    It's already been a year since I started Hair Transplant.I can't think of a frog tadpole.. It's become so natural now that I don't even know if I've had hair loss.. I'm not sureThis was before the surgery  Looking at it like this, it was really bad..It was a time when I was covering up the M shape because I was embarrassed just by blowing the wind..And on the first day of surgery It was really dense lolI thought I wanted this to be my head, and I remember being really happy.And it's been 6 months I was actually a little worried at this time.Anyway, I knew it was going to get denser, but it was a time when it was full.And this is my last year's hair lol I slept really well, right?I'm really confident nowI don't care whether it's windy or notThese days, I'm so happy to find my bangs that were abundant in my 20s.It's all thanks to the director Choi Dongwook who did a great job Thank you!

    조회수 1,323
    댓글 4
    포토후기 이미지
    바람부는날에도 성형외과의원
    Banal Plastic Surgery Clinic

    My hair is thin and thin, so I visited at first as a Hair Transplant consultation, but after the consultation, I heard that forehead reduction is more suitable for my condition, so I proceeded. Director Park Soo-ho explained the operation method, recovery process, and genuine endotin used in detail, so I trusted him. There was a private recovery space before and after the surgery, so I was able to relax a lot with my guardian and the overall movement and care were comfortable. It's not that I don't have scars at all, but it's a line just below my hair, so it's not as noticeable as I thought, and people around me don't know at all. I've always been stressed out with a wide forehead since I was young, but now I feel confident tying my hair, and I feel like I've solved my lifelong worries, so I'm so satisfied :)

    조회수 1,225
    댓글 9
    포토후기 이미지
    알파모의원
    an alpha-mocking circle

    Alpha Mo Clinic, 4/7th, 10 a.m. surgery, now 19th day of 4/26. We're going into the 3rd weekThere's a hair loss. I went around the Gangnam area and received about 15 consultations, and there were some advantages in the amount of money,The director's speaking skills were not affected at all, but I think I was convinced by the posts he posted on his personal blog.At the first consultation, I was diagnosed with a 3600 mother (the condition of lowering the line), but I personally don't want to lower the lineIn the end, through a long conversation with the counseling manager, fill the m shape without lowering the line, and proceed with the rest of the density reinforcement feelingI finished the consultation and got the procedure scheduled. (He said that my hair will be filled with 2500 hats based on the m shape.)Face-to-face consultation was conducted twice before surgery and visited the hospital before 09:15 minutes on the day of surgery, and final design after preparation10:00 After sleeping anesthesia, the anesthesia is released in the middle of the laryngeal extraction at 12:00, so you pull it out with a laryngeal punchIt hurt a lot, so I asked for more anesthetic injections in the middle.I was hit by a few hits near my forehead and I was lying down because it was okayAfter that, I went to the bathroom once, looked at the ceiling, and was transplanted with a placenta machine while lying down. I woke up in the middleI really wanted to go to the bathroom. I tried to ask you how many minutes are left, but you said, "I planted it." So I held it inHe planted it in his hair like a mosquito repellent. It was really fast2 hours of collection, 2 hours of transplantation, so it ended before 14:00After it was over, I ate sweet snacks, and I came back home because I gave you a pear crab and a precautionary spray.I didn't have any anesthetic pain or hair pain, but I didn't sleep well on the first day.I woke up every hour, and it looked more like an anesthesia than a headacheThe next day, I went back to the hospital after shampooing. And after shampooing at home, something came up yellowIt swelled up and it was weird, so I sent a picture to the hospital KakaoTalk, and I thought I would have to do Benong or drainage on the transplanted area, so can I go to the hospitalHe visited the hospital at night on the day, burst a few, got an additional shampoo, and applied ointment.Since then, you asked me to send you pictures periodically, so I sent them to you. They put in the laser for free 10 times, so it's possible every time I visitHe said so. I'm a congressman who cares a lot about follow-up careI found out by communicating several times through Kakaotalk. And I had work on the 10th day, so I visited one more time on the 11th day to check the progress.The director's personality is very good at speaking? I always felt that I didn't feel like it. I'm not really curious about anythingWhen the director asks me if I have any questions at the end, I always say it's okay and I don't think we talked properlyRather, I liked it because it was my style rather than people who just spoke. As long as the results come out in a year, and now it's the 19th day,The transplant mothers are falling out little by little. It's said that you're eliminated and then grow back. I hope that time comes soon.The m shape was very deep, and I applied spray for two years at a young age in my 20s, didn't wash, and shampooed the next morning,I also like drinking and playing at night, so I drank a lot, and I was neglecting my body, so I think I played a part in deepening the m shapeI ate blood for about 7 months, and I went to the hospital because I thought it wouldn't work out, but I'm satisfied so far, except for the thought that I should have gone a little earlier.Lastly, I will finish by posting four pictures of the center, left, right, and occipital. 

    조회수 1,781
    댓글 5
    포토후기 이미지
    대전 리즈모 모발이식 센터
    Rizmo Clinic - Daejeon Branch

     Hair loss has progressed slowly since about five years ago, and at first, it didn't matter, but at some point, it bothers me every time I look in the mirror. I tried medicine and managed it, but there was no noticeable change, so I ended up thinking about Hair Transplant. While looking up various hair loss communities, I was looking for information toward Daejeon Hair Transplant and naturally learned about Daejeon Rizmo Clinic.It could have been cumbersome to find out the hospital from Nonsan where I live to Daejeon, but looking at the reviews, the trust in the Rizmo Clinic in Daejeon gradually built up. It wasn't just an advertising feeling, but there were a lot of actual experiences, and there were a lot of stories that the results were natural, so I was inclined.In the end, I decided to get counseling in person, and I decided that the results were more important than the trouble of moving from Nonsan to Daejeon.When I got counseling, I understood why many people choose Daejeon Rizmo Clinic.The consultation process was very meticulous, and I trusted you because you carefully explained the design and implantation direction suitable for the current condition.I proceeded with a total of 4554 hats in a non-cut manner, and it was impressive to point out exactly what was needed without feeling overly recommended.Even among hospitals in Hair Transplant, Daejeon, I felt that such detailed counseling was not common.On the day of the surgery, it was more nerve-wracking than expected, but the process itself was relatively comfortable.It was a non-cut method, so there was little burden of recovery, and I was relieved that you checked the condition in between. Above all, I felt the proficiency of the medical staff, and I felt that the speed and concentration of progress were quite high.I was glad that I chose Daejeon Rizmo Clinic at this time.It hasn't been long yet, but overall satisfaction is high so far. We have to wait and see the progress in the future, but I feel like I got the first button right. If you've been worried about moving to Daejeon, I think you can consider the results first like me. If you are thinking about Hair Transplant in Daejeon, I think Rizmo Clinic in Daejeon is a good option to consider.

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    Moment Clinic

    It's already been 6 months since the surgery. There was a holiday holiday, and I was a little busy, so I couldn't go to the hospital in the 5th month, and I went to see it for 6 months not too long ago. When I had my first surgery, I was very much waiting for my hair to come up, but now I'm amazed to see how it changes little by little every time I look in the mirror.I saw little hairs coming up from the third to fourth months, and now that I'm in the fifth month, I felt like the number of hairs coming up has increased significantly. In the past, the scalp looked more prominent when the top of the head or the front was reflected in the light, but these days, it looks much less empty than before even in the same lighting. It's almost six months old now, but it's definitely different. The biggest difference is hair thickness. After six months, I can see a lot of children getting thicker like existing hair. The line is being held naturally as it was designed for the first time, and now even when I look in the mirror, I rarely feel as stressed as I used to. Of course, I don't think it's complete yet. The density is likely to rise further in the future, and there seems to be room for a little more filling in the middle. The director said that this is the middle process, but I'm looking forward to it because it will become thicker and denser in about six more months. The progress so far is satisfactory enough, and I'm waiting to see how much better it will get in the future.In the next review, I'll leave it with a richer look.

    조회수 3,386
    댓글 8
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    Motion Hair Clinic

    In my early 20s, I decided to have a hair transplant to correct M-shaped hair loss and lower forehead height, and when I first visited the hospital, both doctors and nurses gave me a reliable explanation, so I started the surgery right away. After that, the scab was removed in the second week, and unlike other hospitals, I was informed that I could start drinking and smoking, and from the first month, the transplant hair began to fall out, and now I have almost no hair.

    조회수 7,850
    댓글 7

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