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Come on, land in the country. If the milk comes out, the operation will be much better Rather than transplants...

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>It's from talmowar.com . It's good news, so I'm scared...
>
>Glaxo Europe approves Dutasteride
>
>July 25, 2002 - GlaxoSmithKline (GSK) announces today that it has received approval from Sweden for dutasteride as a new treatment for prostate hyperplasia. Swedish authorities approved the use of dutasteride in patients requiring surgical operation with prostatic hyperplasia and as a treatment to prevent acute pulmonary symptoms and alleviate severe prostatic hyperplasia. They agreed to act as credit guarantee countries for mutual approval procedures in Europe. And GSK plans to roll out the drug to all major European markets once approval has been decided.
>In a reference to the approval, Dr. Radausson, who is on the European Clinical Development Team at GSK and is a permanent member of the Urology Society, said, "This is great news for both patients and prescribers in choosing new treatments." Clinical trials of dutasteride containing data from more than 4,300 patients with prostatic hyperplasia showed positive effects on the symptoms of prostatic hyperplasia and showed the results of maintaining symptom relief for a long time. For example, the amount of prostate decreased more than plasvo (fake drug users) within a month and continued research, and as a result, it effectively reduced the symptoms of acute phenuria and prostate hyperplasia requiring surgical operation.
>Dutasteride is the first 5-alpha reductase inhibitor to inhibit both type 1 and type 2 of 5-alpha reductase. This enzyme is an enzyme that converts testosterone to DHT in the prostate or in other human tissue organs, and DHT is known to play the most important role in the symptoms of prostate hyperplasia.
>Dutasteride was very effective throughout the clinical experiment, and very common side effects were as follows. Impotence (6%), sexual desire abnormalities and decline (3.7%), range abnormalities (1.8%), and female mastication (1.35) in men.
>Reported by Hairlosshelp.com in January, GSK said the rollout of dutasteride was delayed until sNDA, which includes data from their two-year treatment study, was approved by the FDA. GSK filed sNDA in November 2001, and dutasteride will be released at the time of approval in the United States of sNDA, expected in October 2002.
>Hairlosshelp.com does not have a definite report on whether GSK will initiate a phase 3 hair loss study once the drug is on the market.
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>
>* Comparison of propoxia and dutasteride
>(original material: inhibitory mechanisms of 5-alpha reductase 1,2 and drug human response parameters)
>
>The interaction of dutasteride with 5-alpha reductase was tested at 37°C pH 7 with mouse experiments. This 5-alpha reductase inhibitor has already been known as a time-dependent inhibitor (reducing inhibitory capacity over time: why we should take it for life). However, although dutasteride is a time-dependent inhibitor for 5-alpha reductase 2, it is a typical equilibrium autophagy for 5-alpha reductase 1. This phenomenon is the result of pinasteride, which is already used as a prostate treatment. Inhibition of 5-alpha reductase by dutasteride competes with testosterone, with the K(i) value of Michaelis-Menten (enzyme and substrate reaction rate equation) being 0.3±0.02 nM.
>The inhibition data for 5-alpha reductase 2 of dutasteride are consistent with a two-step mechanism. That is, K(i) is the dissociation constant of the enzyme and inhibitor reaction complex, and k(3) is the second rate constant. The pseudo-bimolecular rate constant (k(3)/K(i)) for dissociation after defects in dutasteride and 5-alpha reductase is 2.0±0.4×10(7) M(-1) sec(-1). The high affinity of dutasteride for 5-alpha reductase 2 led to dissociation of each other's defects only after 7 days of dialysis at 4°C. Inhibition of 5-alpha reductase 2 on dutasteride and finasteride inhibits the action of the enzyme with clear, irreversible structural modification, but 5-alpha reductase 1 is a typical reversible inhibitor. Therefore, we can increase the inhibitory effect on 5-alpha reductase 1 as a drug human response parameter, so it can be said that dutasteride is more effective as a treatment for prostatic hyperplasia than finasteride.
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> Source: Biochem Pharmacol Vol. 62, No. 7, 933-942P October 1, 200
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