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  • 24years ago

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Dr Richard Lee of the Los Angeles-based Regrowth Clinic introduced a new anti-androgen lotion for application with 5% Spironolatone. The lotion is designed to be easy to apply to M-shaped recessed or thin hair.

Why Spironolatone? That's because it's a stable foundation for alopecia. Hair loss is initiated by DHTs belonging to cell receptors in hair follicles, as is commonly known for male hair loss or such types of hair loss. DHTs synthesized in these cell receptors are heterogeneous in the body, and these immune systems destroy hair follicles, shorten the hair cycle, cause hair loss, and deteriorate tissue.
The good news is that they are hair follicles with genetic elements that are about to mature to their previous size.

Although it has achieved some therapeutic effect with pinnesteride, which has succeeded in reducing a significant amount of DHT on the scalp of male hair loss patients, doctors and researchers have turned to other drugs known as antiandrogen activity.
However, there must be some standard for antiandrogen, which can even change the form of alopecia or be used for suppression.

The properties of the ideal antiandrogen should be as follows.
1) Strong anti-androgen activities should be possible.
2) DHT should be able to be successfully inhibited without altering selective inhibition or testosterone levels.
3) It should be a formulation that can be applied effectively, and it should also be applicable with minoxidil.
4) Even if it is easily absorbed into the skin, there should be no side effects.

Satisfying these matters is very difficult, but surprisingly, Spironolatone has these medicinal effects. And this drug is not a new drug, and for more than 30 years Spironolatone has been used as an antihypertensive and diuretic.
More recently, it has been used to remove female hair. It may sound contradictory that Spironolatone is used to remove hair, but because the body's hair (chest, face, armpit, e.g.) is developed by testosterone and Spironolatone is a powerful antiandrogen, it has been used to remove hair that is not needed by the body.

Conversely, the hair on the top of the head has the opposite effect by DHT, and Spironolatone has the opposite effect, that is, the hair growth effect. In addition, the effect of antiandrogen in Spironolatone is that it appears in both men and women.
When taken orally, it is like a powerful antiandrogen, and even if it is an effective antihypertensive drug, it is extremely rarely used to treat men as an antihypertensive agent because it becomes feminized and causes pain in the breast.
However, when it comes to topical application, Spironolatone does not have any side effects.

The medical evaluation of the determination of spironolatone as a topical application agent is that "the use of spironolatone for application is also considered to have a very high penetration effect and a high effect."
Physicians have been treating patients with male hair loss for more than 12 years without problems and have not been briefed on any side effects

Depending on the properties of the antiandrogen, spironolatone becomes a major factor capable of inhibiting DHT in cell receptors. Therefore, Spironolatone effectively inhibits the synthesis of DHT from cell receptors in hair follicles. As a result, the hair follicles can no longer weaken and return to normal hair. And it is done without a decrease in DHT levels in the human body.
Finestrid, for example, interferes with the production of DHT itself, resulting in side effects in many patients.
Analyzing the files of Spironolatone of various pharmaceutical centers from various angles shows that it is effective when applied locally. For the anti-androgen effect of Spironolatone for topical application in dermatology, the researchers were based on determining the concentration of Spironolatone by performing a reduction reaction for one dose.

Dr Lee said lotion containing 5% Spironolatone will be available in September and has yet to announce the price. For more information, please visit www.minoxidil.com

Operations frequently) As a result of visiting the site above, we checked the current commercial status. However, the above product is a specialty drug, and in the case of specialty drugs, it must be taken by a specialist's prescription and instruction.
In addition, there are no proven results for stability or efficacy in the FDA.

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