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[re] 아젤리아에 무슨 성분이 있길래 그러죠?

22년 전
2,861

<두타방에서 아디:두타님이 올리신 글입니다.>
논문인것 같기도한데 영어 해석하신님들 글 읽어보니 아젤리아산이 DHT타입1 제거 효과가
있다고 하시네요..
일반 프페,프카등은 타입2만 억제효과과 있는 반면 아젤리아산과 아연 B6 을같이 쓰면
타입1이 거의 100%억제된다는 말같네요..

똑똑한 님들이 해석 하셨는데 아젤리안 산만으로도 별개의 효과로 억제 되는건지
아연과 B6을 같이 썻을때 시너지 효과가 나오는건지 해석하신분들이 약간 헷갈려 하시더라구요

그리하여 아젤리아 연고랑 아연이이들어 있는 노비드 가 탄생 한것입니다....... 이것이 대충의
아젤리아 사건 개요 입니다..^^
모두 두타방에서 발췌하고 종합한것입니다.
두타방가시면 누가 방법 쫘~~~ 정리 해놓으셨어요~~

왠지 기분이 좋습니다.

Azelaic acid 5%
Proven to inhibit up to 100% of DHT where applied
Clinical Pharmacology: The exact mechanism of action of azelaic acid is not known. The
antimicrobial action may be attributable to inhibition of microbial cellular protein synthesis. Azelaic acid at high concentrations is bactericidal against Propionibacterium acnes and Staphylococcus epidermis and possesses bacteriostatic properties against a variety of aerobic microorganisms, including Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Candida albicans. In vitro, azelaic acid acted as a scavenger of oxy radicals and inhibits a variety of oxidoreductive enzymes including 5-alpha reductase, the enzyme responsible for converting testosterone to DHT. Azelaic acid (0.1 to 3.0 mmol/l) has been shown to produce a competitive concentration dependent inhibition of 5-alpha reductase activity in homogenates of human foreskin. Azelaic acid is being studied for potential antimycotic and antiviral properties. The multiple actions of azelaic acid cause a normalization of keratinization and a decrease in the free fatty acid content of skin surface lipids.

Pharmacodynamics: Following a single application to human skin, 3 to 5% of the azelaic acid
penetrates into the strateum corneum (up to 10% is present in the dermis and epidermis). There
is negligible cutaneous metabolism after topical application. Approximately 4% of topically
applied azelaic acid is systemically absorbed and mainly excreted unchanged in the urine. The
half-life is approximately 12 hours after topical dosing, indicating percutaneous absorption
rate-limited kinetics. After topical treatment with azelaic acid, plasma concentration and urinary excretion are not significantly different from baseline levels.

Contraindications: Azelaic acid solutions or lotions are contraindicated in individuals who have shown hypersensitivity to any of their components.

Azelaic acid may be useful as a hair growth stimulant. A research report by Stamatiadis in 1988 suggested that azelaic acid (and combinations of it and zinc ion and vitamin B6) was a strong type I 5-alpha reductase (5-AR) inhibitor. The enzyme 5-AR (both types I and II) convert testosterone to dihydrotestosterone (DHT). DHT has been shown to contribute to male prostate enlargement (benign prostatic hyperplasia, BPH) and to damage hair follicles. The abstract of that article is further down this page.

We have not seen research that directly links the use of topical azelaic acid (or azelaic acid with zinc and B6) with hair growth. We feel that there is sufficient literature backing (in the Stamatiadis study and others) to include it in a Crinagen preparation.

Some people have obtained Skinoren azelaic acid cream (which is 20% azelaic acid) from New Zealand and are spreading thin layers of it on their scalps - either before or after applying Crinagen. We don't know what success they are having. We have not had sufficient feedback from these subjects at this point. Because 20% azelaic acid is a very potent strength, we are suggesting that these people use it only with a physician's supervision. At the very least, they should consider diluting the 20% azelaic acid to 5% or less by mixing it with neutral creams.

Abstract of Stamatiadis' 1988 study:

Br J Dermatol 1988 Nov;119(5):627-632 Inhibition of 5 alpha-reductase activity in human skin by zinc and azelaic acid.

Stamatiadis D, Bulteau-Portois MC, Mowszowicz I

Laboratoire de Biochimie B, Hopital Necker-Enfants-Malades, Paris, France.

The effects of zinc sulphate and azelaic acid on 5 alpha-reductase activity in human skin were studied using an in vitro assay with 1,2[3H]-testosterone as substrate. When added at concentrations of 3 or 9 mmol/l, zinc was a potent inhibitor of 5 alpha-reductase activity. At high concentrations, zinc could completely inhibit the enzyme activity. Azelaic acid was also a potent inhibitor of 5 alpha-reductase; inhibition was detectable at concentrations as low as 0.2 mmol/l and was complete at 3 mmol/l. An additive effect of the two inhibitors was observed. Vitamin B6 potentiated the inhibitory effect of zinc , but not of Azelaic acid , suggesting that two different mechanisms are involved. When the three substances were added together at very low concentrations which had been shown to be ineffective alone, 90% inhibition of 5 alpha-reductase activity was obtained. If this inhibition is confirmed in vivo, zinc sulphate combined with azelaic acid could be an effective agent in the treatment of androgen related pathology of human skin.

위에 내용을 보면 Azelaic acid 크림과 아연 크림 비타민b6가 아주 유용하다는군요..
Azelaic acid 는 dht type1을 거의 100%까지 제거 한대요..
프페가 type2형을 억제하니 같이 쓰면 시너지 효과가 잇지 않을까요?

아젤리아 라고 약국가면 Azelaic acid 20% 5천 800원에 구할수 잇어요..10mg 짜리..
위에 내용으로라면 희석해서 쓰라네요..5%로..
그리고 zinc(아연)은 너무많이 발라도 너무적게 발라도 부작용으로 탈모가 일어 날수도 있다고
하네요.growth.com에서..

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