[주제토론] 의학이나 약학 관련 지식 많으신분 계신가요 약빨 줄어드는거에 관해서요

블락ㅁ · 2014-03-17T19:48:48+09:00

보통 2년 정도 먹고 이후부터 약빨이 많이 준다고 하던데 그 이유가 프로페시아로 DHT 농도 낮춘 만큼 모낭세포에 DHT receptor 수가 upregulation 일어나는건가요 upregulation에 대한 보고 같은건 없었나요 이에 관련된 논문이나 주장 같은거 나온적 있는지 아시는분 ㅠㅠ 추가 구글에서 찾아보니까 전립선 세포에서는 finasteride가 DHT receptor 수를 늘렸다는 연구가 있어요 ㅠㅠ Abstract BACKGROUND Although finasteride is recognized for its role as a chemopreventive agent for prostate cancer higher grades of malignancy have been reported It is questioned whether blocking of testosterone conversion to dihydrotestosterone DHT by finasteride in prostate tissue will change expression of androgen receptor AR Therefore this study evaluated the effects of finasteride on AR expression in prostate tissue and in the LNCaP cell line METHODS Between January and December 2006 we retrospectively selected and evaluated 47 cases of benign prostatic hyperplasia treated with variable duration of finasteride 5mg QD before transurethral resection of the prostate AR expression in prostate tissue was semiquantified by immunostaining and compared with duration of finasteride treatment An androgendependent prostate cancer cell line LNCaP was cultured in charcoaldextrantreated FBS with DHT or testosterone and treated with finasteride for 182113 weeks Samples of total RNA were collected to analyze expression of AR by realtime quantitative reverse transcription polymerase chain reaction RESULTS Immunohistochemical study revealed significant upregulation of ARs by finasteride treatment for 308211180 days In cell line study quantitative realtime reverse transcription polymerase chain reaction revealed significant upregulation of ARs treated by finasteride CONCLUSIONS In our study finasteride influenced AR expression in benign prostate tissue and prostate cancer cell Before we can use finasteride in chemoprevention with confidence we still need to clarify the influence of finasteride in ARs and its regulation pathway Prostate ⓒ 2011 WileyLiss Inc