보통 2년 정도 먹고 이후부터 약빨이 많이 준다고 하던데
그 이유가
프로페시아로 DHT 농도 낮춘 만큼
모낭세포에 DHT receptor 수가 upregulation 일어나는건가요??
upregulation에 대한 보고 같은건 없었나요?
이에 관련된 논문이나 주장 같은거 나온적 있는지 아시는분? ㅠㅠ
+추가
구글에서 찾아보니까 전립선 세포에서는 finasteride가 DHT receptor 수를 늘렸다는 연구가 있어요 ㅠㅠ
Abstract
BACKGROUND
Although finasteride is recognized for its role as a chemopreventive agent for prostate cancer, higher grades of malignancy have been reported. It is questioned whether blocking of testosterone conversion to dihydrotestosterone (DHT) by finasteride in prostate tissue will change expression of androgen receptor (AR). Therefore, this study evaluated the effects of finasteride on AR expression in prostate tissue and in the LNCaP cell line.
METHODS
Between January and December 2006, we retrospectively selected and evaluated 47 cases of benign prostatic hyperplasia treated with variable duration of finasteride (5?mg QD) before transurethral resection of the prostate. AR expression in prostate tissue was semiquantified by immunostaining and compared with duration of finasteride treatment. An androgen-dependent prostate cancer cell line (LNCaP) was cultured in charcoal/dextran-treated FBS with DHT or testosterone, and treated with finasteride for 1–3 weeks. Samples of total RNA were collected to analyze expression of AR by real-time quantitative reverse transcription polymerase chain reaction.
RESULTS
Immunohistochemical study revealed significant upregulation of ARs by finasteride treatment for 30–180 days. In cell line study, quantitative real-time reverse transcription polymerase chain reaction revealed significant upregulation of ARs treated by finasteride.
CONCLUSIONS
In our study, finasteride influenced AR expression in benign prostate tissue and prostate cancer cell. Before we can use finasteride in chemoprevention with confidence, we still need to clarify the influence of finasteride in ARs and its regulation pathway. Prostate ⓒ 2011 Wiley-Liss, Inc.
☞ 본 게시판에서 모발이식 수술 후기는 신고 바랍니다. (삭제 및 탈퇴)
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