피나스테라이드: 프로페시아,핀페시아,프로스카,핀카등 전세계 피나스테리드계열 제네릭의약품 정보.

두타스테라이드: 아보다트, 제네릭아보다트 정보/ 미녹시딜정 : 먹는 미녹시딜 / 스피로놀락톤:알닥톤,스피로닥톤

미녹시딜 5%액 : 로게인,리게인, 잔드록스,마이녹실,스칼프메드등 minoxidil계열의 정보

기타의약품:시메티딘,로아큐탄,스티바A(트레티노인),다이안느, 드로겐정, 판토가

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[두타스테리드] Azelaic acid 5% Proven to inhibit up to 100% of DHT

23년 전
4,994

Azelaic acid 5%
Proven to inhibit up to 100% of DHT where applied
Clinical Pharmacology: The exact mechanism of action of azelaic acid is not known. The
antimicrobial action may be attributable to inhibition of microbial cellular protein synthesis. Azelaic acid at high concentrations is bactericidal against Propionibacterium acnes and Staphylococcus epidermis and possesses bacteriostatic properties against a variety of aerobic microorganisms, including Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Candida albicans. In vitro, azelaic acid acted as a scavenger of oxy radicals and inhibits a variety of oxidoreductive enzymes including 5-alpha reductase, the enzyme responsible for converting testosterone to DHT. Azelaic acid (0.1 to 3.0 mmol/l) has been shown to produce a competitive concentration dependent inhibition of 5-alpha reductase activity in homogenates of human foreskin. Azelaic acid is being studied for potential antimycotic and antiviral properties. The multiple actions of azelaic acid cause a normalization of keratinization and a decrease in the free fatty acid content of skin surface lipids.

Pharmacodynamics: Following a single application to human skin, 3 to 5% of the azelaic acid
penetrates into the strateum corneum (up to 10% is present in the dermis and epidermis). There
is negligible cutaneous metabolism after topical application. Approximately 4% of topically
applied azelaic acid is systemically absorbed and mainly excreted unchanged in the urine. The
half-life is approximately 12 hours after topical dosing, indicating percutaneous absorption
rate-limited kinetics. After topical treatment with azelaic acid, plasma concentration and urinary excretion are not significantly different from baseline levels.

Contraindications: Azelaic acid solutions or lotions are contraindicated in individuals who have shown hypersensitivity to any of their components.

Azelaic acid may be useful as a hair growth stimulant. A research report by Stamatiadis in 1988 suggested that azelaic acid (and combinations of it and zinc ion and vitamin B6) was a strong type I 5-alpha reductase (5-AR) inhibitor. The enzyme 5-AR (both types I and II) convert testosterone to dihydrotestosterone (DHT). DHT has been shown to contribute to male prostate enlargement (benign prostatic hyperplasia, BPH) and to damage hair follicles. The abstract of that article is further down this page.

We have not seen research that directly links the use of topical azelaic acid (or azelaic acid with zinc and B6) with hair growth. We feel that there is sufficient literature backing (in the Stamatiadis study and others) to include it in a Crinagen preparation.

Some people have obtained Skinoren azelaic acid cream (which is 20% azelaic acid) from New Zealand and are spreading thin layers of it on their scalps - either before or after applying Crinagen. We don't know what success they are having. We have not had sufficient feedback from these subjects at this point. Because 20% azelaic acid is a very potent strength, we are suggesting that these people use it only with a physician's supervision. At the very least, they should consider diluting the 20% azelaic acid to 5% or less by mixing it with neutral creams.

Abstract of Stamatiadis' 1988 study:

Br J Dermatol 1988 Nov;119(5):627-632 Inhibition of 5 alpha-reductase activity in human skin by zinc and azelaic acid.

Stamatiadis D, Bulteau-Portois MC, Mowszowicz I

Laboratoire de Biochimie B, Hopital Necker-Enfants-Malades, Paris, France.

The effects of zinc sulphate and azelaic acid on 5 alpha-reductase activity in human skin were studied using an in vitro assay with 1,2[3H]-testosterone as substrate. When added at concentrations of 3 or 9 mmol/l, zinc was a potent inhibitor of 5 alpha-reductase activity. At high concentrations, zinc could completely inhibit the enzyme activity. Azelaic acid was also a potent inhibitor of 5 alpha-reductase; inhibition was detectable at concentrations as low as 0.2 mmol/l and was complete at 3 mmol/l. An additive effect of the two inhibitors was observed. Vitamin B6 potentiated the inhibitory effect of zinc , but not of Azelaic acid , suggesting that two different mechanisms are involved. When the three substances were added together at very low concentrations which had been shown to be ineffective alone, 90% inhibition of 5 alpha-reductase activity was obtained. If this inhibition is confirmed in vivo, zinc sulphate combined with azelaic acid could be an effective agent in the treatment of androgen related pathology of human skin.

위에 내용을 보면 Azelaic acid 크림과 아연 크림 비타민b6가 아주 유용하다는군요..
Azelaic acid 는 dht type1을 거의 100%까지 제거 한대요..
프페가 type2형을 억제하니 같이 쓰면 시너지 효과가 잇지 않을까요?

아젤리아 라고 약국가면 Azelaic acid 20% 5천 800원에 구할수 잇어요..10mg 짜리..
위에 내용으로라면 희석해서 쓰라네요..5%로..
그리고 zinc(아연)은 너무많이 발라도 너무적게 발라도 부작용으로 탈모가 일어 날수도 있다고
하네요.growth.com에서..

본 게시물의 내용은 이용자의 개인적인 경험 및 공개된 일반 정보를 바탕으로 작성된 것으로, 특정 의약품의 광고, 홍보 또는 사용을 권유하기 위한 목적이 아닙니다. 전문의약품의 사용 여부 및 치료에 관한 사항은 반드시 의료 전문가와 상담하시기 바랍니다.

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[두타스테리드] Azelaic acid 5% Proven to inhibit up to 100% of DHT

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