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[피나스테리드] Re: 피나스트리드와 부작용 관계

25년 전
2,004

약먹기 전 탈모가 진행 중이었다면, 그게 수그러들기까진 일정 시간이
필요할 것입니다. 휴지기 탈모는 아래 글에 내용이 나옵니다. 영어를
전부 해석해 놓기는 그렇고 휴지기 탈모를 언급하는 부분만 해석해
놓겠습니다.

(중략) telogen effluvium, which typically started 11 to 16 weeks after initiating therapy with finasteride. (중략)
대개 피나스트리드를 복용한 뒤 11 에서 16 주 후부터 발생하는 휴지기 탈모 ...

그러니까, 만약 피나스트리드를 복용한 뒤 멀쩡하던 머리가 11 ~ 16 주 사이에
갑자기 많이 빠지기 시작해서 쉐딩처럼 느껴진다면 휴지기 탈모를 의심해
볼 수 있겠지요. 드문 현상이라고 하고, 저도 피나스트리드로는 겪어 보지
못했습니다.

원문입니다.

DAVID asked: "Dr. Lee, I'm wondering about your previous remarks. I have included them at the bottom of my question for your reference. 'telogen effluvium just caused an earlier onset (at least a few years) of MPB'." as you have stated wouldn't Propecia sheds be similiar? I mean I'm on Propecia and I'm shedding a lot of terminal hairs and if these hairs are affected my MPB and grows back thinning and finner then theoritically wouldn't this mean that Propecia is accelerating my MPB by inducing terminal hair to shed and miniturized hairs to grow back? Please advise. thanks. "Wow! That is a complicated question, but I think I understand what you are asking. I have no doubt that you have experienced at least one bout of telogen effluvium. In a simple, uncomplicated case of telogen effluvium, some physiological stress causes anagen hairs to shift into the telogen phase. Barring any intervening factors, the hair will begin to grow back again in 3 to 4 months and will have the same texture as the hair shaft that was shed. A telogen effluvium affects hair in all parts of the scalp, including those areas, which are normally uninvolved in MPB, i.e. the sides and the back of the head. It does not cause any 'specific spots', but is a diffuse shedding of hair. Within a year, almost all patients will have regained all their hair. However, if the telogen effluvium occurs at a time when all the factors that cause MPB are operative, those hairs that are risk for MPB will grow back as finer hairs from smaller follicles. In fact, for some unfortunate patients, a period of telogen effluvium will herald an accelerated phase of MPB. You've probably read of cases in which patients seemed to have lost all their hair 'overnight'. These are extreme examples, but you can conclude from them that 'telogen effluvium just caused an earlier onset (at least a few years) of MPB'.""

Dr Richard Lee, MD answered: "Merck does not report hair shedding due to Propecia. However, there are at least a few cases reported that suggests a telogen effluvium, which typically started 11 to 16 weeks after initiating therapy with finasteride. I don't have accurate follow-up reports of these patients, so I can't tell you whether or not they continued taking Propecia. Nor can I tell you about the final outcome of their hair. Anyway, if they discontinued taking finasteride, but used an alternative effective method for reducing the DHT in the scalp, there would not be any reason to expect that the replacement hairs would be of the same quality than the hairs that were shed in the telogen effluvium. You have an exceedingly complex medical history and I'm not at all sure that your increased shedding is due to taking Propecia."

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