지난 주 댓글 랭킹

1등 K5041298252
2등 K39623145472503141814
3등 K5036216394
4등 K5039510942
5등 우리사는이곳

6등 천억만벌자
7등 audryman
8등 K5005793852
9등 괜히사서고생
10등 K5036139709

[re] 막스플랑크인스티튜트의 연구결과중 가장 중요한 걸로 보이는 글입니다.

21년 전
1,268

남성형 탈모증과는 전혀 상관없는 내용입니다..

>Forkhead/winged-helix transcription factor Whn regulates hair keratin gene expression: molecular analysis of the nude skin phenotype.
>
>Schlake T, Schorpp M, Maul-Pavicic A, Malashenko AM, Boehm T.
>
>Department of Developmental Immunology, Max-Planck-Institute for Immunobiology, Freiburg, Germany.
>
>The molecular characteristics of the nude phenotype (alopecia and thymic aplasia) in humans and rodents are unknown. The nude locus encodes Whn, a transcription factor of the forkhead/winged-helix class. Expression of Whn in HeLa cells induced expression of human hair keratin genes Ha3-II and Hb5. Correspondingly, in nude mice, which are homozygous for a loss-of-function mutation of Whn, expression of mouse mHa3 and mHb5 hair keratin genes is severely reduced. Characterization of a previously identified nude allele, nu(Y), revealed a mis-sense mutation (R320C) in the DNA binding domain of Whn. This mutant protein is unable to activate hair keratin gene expression in HeLa cells. When the Whn transcription factor was expressed in two parts, one containing the N-terminal DNA binding domain and the other the C-terminal activation domain, no activation of hair keratin genes in HeLa cells was observed. However, when these two proteins were noncovalently linked by means of synthetic dimerizers, hair keratin gene expression was induced. This finding suggests that target gene activation by Whn depends on the structural integrity and physical proximity of DNA binding and activation domains, providing a molecular framework to explain the loss-of-function phenotypes of all previously characterized nude mutations. Our results implicate Whn as a transcriptional regulator of hair keratin genes and reveal the nude phenotype as the first example of an inherited skin disorder that is caused by loss of expression rather than mutation of keratin genes.
>

☞ 성의 있는 글 하나가 큰 힘이 됩니다. 무성의 게시글,댓글은 신고바랍니다.
☞ 본 게시판에서 모발이식 수술 후기는 신고 바랍니다. (삭제 및 탈퇴)

최신순
추천순

모발이식 포토&후기

1 16

최신 인기 게시물

지난 주 댓글 랭킹

[re] 막스플랑크인스티튜트의 연구결과중 가장 중요한 걸로 보이는 글입니다.

댓글

모발이식 포토&후기

우리동네 모발이식 병원지도