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[해외뉴스] 상피세포를 이용한 모근 세포 재생에 관한 뉴스 | 대한민국 1등 탈모 커뮤니티 대다모

푸른마음 · 2014-02-21T18:50:15+09:00

14년 1월 29자 해외뉴스입니다 하기 주소를 클릭하시면 인간의 상피세포를 이용하여 모근 줄기 세포를 만들어 냈다고 합니다 이러한 줄기세포를 다시 쥐에 투입하여 인간 모낭세포와 유사한 세포를 재생에 성공 하였다 합니다 가능성이 보입니다ㅋ 크롬까시고 번역하면 어느정도는 이해가능합니다 Cure for baldness Hairfolliclegenerating stem cells bring hope Wednesday 29 January 2014 8am PST DermatologyStem Cell ResearchBiology Biochemistryadd your opinionemailMNT FeaturedAcademic Journal Add your rating Current ratings for Cure for baldness Hairfolliclegenerating stem cells bring hope Public Patient1 2 3 4 55 ratings Health Professionals1 2 3 4 510 ratings According to the American Hair Loss Association twothirds of men will experience hair loss by the age of 35 But women are also affected making up 40 of all hair loss sufferers Affecting selfimage and emotional wellbeing the condition has been a difficult one to treat But a new study brings hope in the form of human hairfolliclegenerating stem cells Researchers from the Perelman School of Medicine at the University of Pennsylvania have published results of their study in Nature where they describe the method by which they were able to convert adult cells into epithelial stem cells EpSCs Although using stem cells to regrow hair follicles has been a potential technique for combatting baldness until now nobody has been able to produce enough of these cells The team says they are the first to achieve this result in either humans or mice Led by Dr Xiaowei George Xu associate professor of pathology and laboratory medicine and dermatology at the University of Pennsylvania the scientists started their research by using human skin cells called dermal fibroblasts How did the team produce the cells The researchers converted the human skin cells into induced pluripotent stem cells iPSCs by adding three genes These iPSCs are able to change into any cell types in the body so the researchers converted them into epithelial stem cells which are normally found in a part of hair follicles Hair shafts The arrows show hair shafts which were formed by iPSCderived epithelial stem cells Image credit Ruifeng Yang Perelman School of Medicine University of Pennsylvania Using techniques from other research teams to convert iPSCs into keratinocytes a main cell type in the top layer of the skin Dr Xu and colleagues showed they could force the iPSCs to make large quantities of EpSCs by controlling the timing of growth factors the cells received When they implanted these EpSCs into mice the cells regenerated cell types of human skin and hair follicles and also created recognizable hair shafts which the team says shows promise for eventually regrowing hair in humans In 18 days 25 of the iPSCs converted into EpSCs which were then purified using the proteins expressed on their surfaces the team notes Technique not yet ready for humans After mixing the humanderived EpSCs with dermal cells from mice the team grafted them onto the skin of the mice and produced a functional human epidermis the outermost layers of the skin The hair follicles that were produced from this notes the team were structurally similar to human hair follicles Dr Xu says that this is the first time anyone has made scalable amounts of epithelial stem cells that are capable of generating the epithelial component of hair follicles adding that the cells could aid in wound healing cosmetics and hair regeneration However these cells are not yet ready for use in humans because the team has only solved one part of the equation A hair follicle contains both epithelial cells and a certain kind of adult stem cell called dermal papillae Dr Xu explains When a person loses hair they lose both types of cells We have solved one major problem the epithelial component of the hair follicle We need to figure out a way to also make new dermal papillae cells and no one has figured that part out yet However he adds that stemcell researchers are beginning to use new strategies using only chemical agents which could result in more solutions In late 2013 Medical News Today reported on a study that showed how scientists successfully grew human hairs from dermal papilla cells taken from the inside of donor hair follicles suggesting we are a step closer to a cure for baldness Written by Marie Ellis